Control of Parturition in the Sow Using Progesterone and Prostaglandin

Gooneratne, A. D.; Hartmann, PE; McCauley, I.; Martin, C

doi:10.1071/bi9790587

Cited by 31 publications

(26 citation statements)

References 17 publications

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“…Despite a decrease following parturition, our data confirm that plasma PRL concentrations remain relatively high thereafter, which is likely due to stimulation by the suckling piglets [36,37]. The existence of a negative correlation between P4 and E2 and, between P4 and PRL, together with the coincidental fall of P4 on the one hand and rises in E2 and PRL on the other hand, support the proposed role of the P4 decrease as the trigger for other hormonal variations at parturition [3,4,35,38].…”

Section: Plasma Hormones Lactose and Igg Variations Around Parturitionsupporting

confidence: 75%

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

et al. 2004

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-Blood, colostrum and saliva samples were serially taken from 6 multiparous sows from day 109 of gestation until day 3 postpartum. Plasma was assayed for oestradiol-17β (E2), progesterone (P4), prolactin (PRL), cortisol, immunoglobulin G (IgG) and lactose. Colostrum was assayed for E2, P4, IgG and lactose. Lactoserum, obtained after ultra centrifugation of colostrum, was assayed for PRL. Saliva was assayed for cortisol. Time-related variations in hormone, IgG and lactose concentrations measured in plasma were parallel to those measured in colostrum, lactoserum or saliva. However, the concentrations were higher in colostrum or lactoserum and lower in saliva than in plasma. Ratios of concentrations of cortisol in saliva and PRL in lactoserum over those in plasma did not vary with time and averaged 0.2 and 1.6, respectively. Conversely, the ratios of concentrations of E2 and P4 in colostrum over those in plasma varied with time (P < 0.05) but were quite constant before the end of parturition, averaging 2.7 and 3.6, respectively. The ratios of concentrations of IgG and lactose in colostrum over those in plasma also varied with time (P < 0.05). The concentrations of hormones in plasma on the one hand and in colostrum, lactoserum or saliva on the other hand were significantly correlated but correlations varied with time (PRL across periods: r = 0.31; cortisol across periods: r = 0.60; E2 during parturition: r = 0.83; P4 before parturition: r = 0.82; P4 during parturition: r = 0.67). The present results indicate that around parturition, assays of hormones in colostrum or saliva can be used to study the hormonal status of sows. Furthermore, variations in colostrum and plasma concentrations of IgG and lactose are good indicators of the transition from colostrum to milk synthesis. sow / parturition / steroid / prolactin / lactose / immunoglobulins

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Section: Plasma Hormones Lactose and Igg Variations Around Parturitionsupporting

confidence: 75%

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

et al. 2004

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“…Although the accumulation of lactose in the mammary tissue of the rat is a convenient method of determining the initiation of lactose synthesis, it is not possible to use this criterion in larger species. Therefore, in studies in cows (Hartmann 1973), ewes , women (Kulski et al 1977(Kulski et al , 1978 and sows (Gooneratne et al 1979), the initiation oflactose synthesis during lactogenesis has been determined by changes in the concentration of lactose in the mammary secretion.…”

Section: Introductionmentioning

confidence: 99%

Progesterone Control of the Initiation of Lactose Synthesis in the Rat

Nicholas¹,

Hartmann²

1981

Aust. Jnl. Of Bio. Sci.

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The in vitro incorporation of ['4C]glucose into lactose in mammary tissue, the concentration of lactose in the mammary tissue and the concentration of lactose in the mammary secretion were determined during late pregnancy and lactation in the rat. These changes were related to the decline in blood progesterone during late pregnancy. The incorporation of [,4C]glucose into lactose was detected on day 20 of pregnancy; it increased gradually until day 22 and then increased rapidly just prior to term (day 23 of pregnancy) to reach mean ± s.e.m. maximum hourly values of 12·0 ± 1· 5 cpm x 10 4 1 g by day 3 of lactation, and then declined to lower values (6· 1 ± 0·6 cpm x 10 4 /g) by day 20 of lactation. The concentration of lactose both in the mammary tissue and in the mammary secretion increased rapidly over the last 24 h of pregnancy and then more gradually after birth to reach mean ± s.e.m. maximum values of 6·85 ± 1 ·11 mg/g tissue and 43·1 ± 2·1 gil respectively on day 15 of lactation. The decline in plasma progesterone to low levels between days 21 and 22 of pregnancy preceded the rapid increase in the concentration of lactose in the mammary tissue. A similar relationship was observed between the decline in progesterone and the increase in lactose in mammary tissue in rats Caesarean-sectioned on day 19 of pregnancy, and the administration of progesterone immediately following Caesarean section significantly depressed the accumulation of lactose in the mammary tissue. The results support the involvement of progesterone withdrawal in lactogenesis in the rat and indicate that ['4C]glucose incorporation into lactose and the concentration of lactose both in the mammary tissue and in mammary secretion are useful indicators of the synthetic activity of the mammary gland.

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“…Another study shown that prolonging the gestation to 116 days using i.m. injections of P4 did not signifi cantly affect litter sizes at birth and at 19 days after farrowing (GOONERATNE et al, 1979). The average number of piglets born reported in that study was around 9, which represents about 5 piglets less than the average obtained with high prolifi c sows in the current study.…”

Section: Discussionmentioning

confidence: 62%

“…Previous experiments demonstrated that sows fed MPA in the last days of gestation underwent spontaneous luteolysis and the endogenous progesterone levels decreased during the treatment period at the same time that in control animals (WHITELY et al, 1990). Similarly, it was demonstrated that exogenous progesterone supplementation between days 112 and 114 of gestation induced corpora lutea regression (GOONERATNE et al, 1979).…”

Section: Discussionmentioning

confidence: 90%