2022
DOI: 10.1101/2022.02.07.479360
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Control of neocortical memory by long-range inhibition in layer 1

Abstract: Mounting evidence identifies layer 1 (L1) as a central site of memory in sensory neocortex. While this work revealed plasticity in several excitatory brain-wide afferent systems, the existence, connectivity and memory-related signaling of long-range inhibitory input to L1 remains elusive. We report that inhibitory afferents from zona incerta project specifically to auditory cortex L1, where they connect selectively to interneurons to disinhibit the cortical circuit and facilitate behavioral memory. Chronic cal… Show more

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“…Neocortical layer 1, long an enigma (Burkhalter 1989; Gămănuţ et al 2018; Hubel 1982; Ibrahim et al 2020; Marín-Padilla 1998), has recently become central to ideas about consciousness and perception (Aru et al 2020; Gidon et al 2020; Guest et al 2021; Ibrahim et al 2021; M. Larkum 2013; Schroeder et al 2022; Suzuki and Larkum 2020; Takahashi et al 2016; Takahashi et al 2020). These ideas seem astonishing for such a cell sparse, tiny layer, located at the surface of cortex, spanning only 100 microns in width, and containing only GABAergic interneurons (Rudy et al 2011; Schuman et al 2021).…”
Section: Introductionmentioning
confidence: 99%
“…Neocortical layer 1, long an enigma (Burkhalter 1989; Gămănuţ et al 2018; Hubel 1982; Ibrahim et al 2020; Marín-Padilla 1998), has recently become central to ideas about consciousness and perception (Aru et al 2020; Gidon et al 2020; Guest et al 2021; Ibrahim et al 2021; M. Larkum 2013; Schroeder et al 2022; Suzuki and Larkum 2020; Takahashi et al 2016; Takahashi et al 2020). These ideas seem astonishing for such a cell sparse, tiny layer, located at the surface of cortex, spanning only 100 microns in width, and containing only GABAergic interneurons (Rudy et al 2011; Schuman et al 2021).…”
Section: Introductionmentioning
confidence: 99%