Control of nanostructures in PVA, PVA/chitosan blends and PCL through electrospinning

Sivaraman, S.; Anand, Anoop; Menon, Deepthy; Nair, Shanti V.

doi:10.1007/s12034-008-0054-9

Cited by 98 publications

(67 citation statements)

References 40 publications

(35 reference statements)

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“…It increases the charge density at the surface of the jet which in turn increases the elongation force and decreases the diameter of the fiber. 45 When the grayscale image was converted to binary form by ImageJ software, various layers of nanofibers could be seen by applying different thresholds. Figure 4 shows the configuration of histograms of PVA and PVA/chitosan nanofibrous scaffolds.…”

Section: Morphology and Porosity Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Alhosseini¹,

Moztarzadeh²,

Mozafari³

et al. 2012

IJN

122

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Among several attempts to integrate tissue engineering concepts into strategies to repair different parts of the human body, neuronal repair stands as a challenging area due to the complexity of the structure and function of the nervous system and the low efficiency of conventional repair approaches. Herein, electrospun polyvinyl alcohol (PVA)/chitosan nano-fibrous scaffolds have been synthesized with large pore sizes as potential matrices for nervous tissue engineering and repair. PVA fibers were modified through blending with chitosan and porosity of scaffolds was measured at various levels of their depth through an image analysis method. In addition, the structural, physicochemical, biodegradability, and swelling of the chitosan nanofibrous scaffolds were evaluated. The chitosan-containing scaffolds were used for in vitro cell culture in contact with PC12 nerve cells, and they were found to exhibit the most balanced properties to meet the basic required specifications for nerve cells. It could be concluded that addition of chitosan to the PVA scaffolds enhances viability and proliferation of nerve cells, which increases the biocompatibility of the scaffolds. In fact, addition of a small percentage of chitosan to the PVA scaffolds proved to be a promising approach for synthesis of a neural-friendly polymeric blend.

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Section: Morphology and Porosity Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Alhosseini¹,

Moztarzadeh²,

Mozafari³

et al. 2012

IJN

122

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show abstract

“…Among the syntheticorigin polymers, those such as poly(ethylene oxide) (PEO), poly(vinyl alcohol) (PVA) and poly(caprolactone) (PCL) are often cited in literature, while poly(L-lactic acid) (PLLA), cellulose and its derivatives, as well as chitin and chitosan, are among the most studied natural renewable-origin polymers Sajeev et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Besides, they have the advantage of being more suitable for processing and do not require purification procedures, which are necessary in some natural polymeric systems (Teo and Ramakrishna, 2006;Kumbar et al, 2008;Sajeev et al, 2008). On the other hand, natural systems usually present multifunctional bioactive properties that grant them superior performance in biological environments due to their higher biocompatibility (Petrulyte, 2008).…”

Section: Introductionmentioning

confidence: 99%

Non-woven nanofiber chitosan/peo membranes obtained by electrospinning

Bizarria

d’Ávila

Mei

2014

Braz. J. Chem. Eng.

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-The present work focused on the preparation and morphological characterization of chitosan-based nanofiber membranes, aiming at applications in medical and pharmacological areas. Membranes with nanofiber diameters ranging from 50 -300 nm were prepared from polymer solutions through the electrospinning process. To stabilize the process, it was necessary to use poly(ethylene oxide) (PEO), which is a biocompatible synthetic polymer. Pure chitosan solutions, as well as chitosan and PEO solution blends, were characterized by their rheological behavior, conductivity, and surface tension measurements. The electrospun fiber thermal characteristics and crystalline structures were investigated through thermogravimetric analysis (TG) and differential scanning calorimetry (DSC). Scanning electron microscopy images (SEM) were used for the morphological evaluations of the membranes. The addition of PEO to the chitosan solutions improved their electrical conductivity, surface tension and viscosity, greatly favoring the electrospinning process. Thus, membranes with 80% chitosan could be electrospun.

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“…Machines able to electrospin fibers can be easily constructed from simple lab supplies for much less, assuming a high-voltage power source is available. For example, the Materials Research Institute (Instituto de Investigaciones en Materiales) of the Universidad Nacional Autónoma de Mexico fabricated their own electrospinning devices, collectors and accessories, giving the group of researchers and students the ability to innovate scaffolds for tissue engineering [10].…”

Section: Electrospun Nanofibers Applicationsmentioning

confidence: 99%

“…These solvents yielded successful PVA nanofiber production [10]. Once dissolved, the solutions were let to settle overnight to remove bubbles.…”

Section: Pva Dissolutionmentioning

confidence: 99%

Designing a Low Cost Electrospinning Device for Practical Learning in a Bioengineering Biomaterials Course

Villareal-Gómez¹

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The electrospinning device is used in the biomaterials research field nowadays for fabricating nanofibers that can be used for manufacturing artificial skin and muscular tissue, blood vessels (vascular grafts), orthopedic components (bones, cartilages, and ligaments/tendon), and peripheral or central nervous system components. Electrospun nanofibers act as ideal scaffolds for tissue engineering and drug delivery systems because they can mimic the functions of native extracellular matrices. A low cost electrospinning device was designed and built for undergraduate practical learning in the Biomaterials course in the area of Bioengineering at Universidad Autónoma de Baja California, México.The methodology includes 3D CAD designing, manufacturing of the acrylic cabinet, different collectors and the fabrication of poly (vinyl alcohol) nanofibrous scaffolds, in order to validate the functionality of the electrospinning system. The prototype is an affordable device; its cost is 95% less than the laboratory commercial devices.Keywords: biomaterials, bioengineering, electrospinning, SOLIDWORKS models, nanofibers. Correspondencia:Luis Jesús Villarreal Gómez RESUMENEl dispositivo de electrohilado es actualmente empleado en la investigación de biomateriales, utilizado para sintetizar nanofibras que ofrecen un potencial para la manufactura de piel artificial y tejido muscular, vasos sanguíneos (implantes vasculares), componentes ortopédicos (hueso, cartílago y tendones/ligamentos) y componentes del sistema nervioso central y periférico. Las nanofibras producidas por electrohilado pueden ser usadas como andamios ideales para ingeniería de tejidos y liberación controlada de fármacos debido a que mimetizan las funciones de la matriz extracelular. El dispositivo de electrohilado de bajo costo fue diseñado y construido para al aprendizaje practico de estudiantes de licenciatura en la asignatura de Biomateriales de la carrera de Bioingeniería. La metodología incluye diseños CAD 3D, manufactura del gabinete de acrílico, diferentes colectores y fabricación de los andamios de nanofibras de Poli (vinil alcohol) para validar la correcta funcionalidad del sistema de electrohilado. El prototipo es un dispositivo accesible económicamente, su costo es un 95% más barato que los dispositivos de tipo comercial.

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Control of nanostructures in PVA, PVA/chitosan blends and PCL through electrospinning

Cited by 98 publications

References 40 publications

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Non-woven nanofiber chitosan/peo membranes obtained by electrospinning

Designing a Low Cost Electrospinning Device for Practical Learning in a Bioengineering Biomaterials Course

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