1986
DOI: 10.1002/aja.1001770109
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Control of myocardial tissue components and cardiocyte organelles in pressure‐overload hypertrophy of the cat right ventricle

Abstract: Previous studies have demonstrated that there is a disproportionate increase in connective tissue in right ventricular myocardium subjected to pressure-overload hypertrophy associated with depressed cardiac contractility. While the myocardium is primarily responsive to load, the aim of the present study was to determine whether catecholamines also modulate the response of myocardial tissue components and cardiocyte organelles in pressure-overload-induced cardiac hypertrophy. Four experimental groups of cats we… Show more

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Cited by 4 publications
(3 citation statements)
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“…Volume overload of the cat right ventricle resulted in a 33.3% increase in this ratio . Even in cats that had developed hypertrophy as a result of a pressure overload, while a t the same time receiving either a-and P-adrenoceptor blockade, the degree of hypertrophy was similar to that seen in this study (Lauva et al, 1986).…”
Section: Musclesupporting
confidence: 84%
See 1 more Smart Citation
“…Volume overload of the cat right ventricle resulted in a 33.3% increase in this ratio . Even in cats that had developed hypertrophy as a result of a pressure overload, while a t the same time receiving either a-and P-adrenoceptor blockade, the degree of hypertrophy was similar to that seen in this study (Lauva et al, 1986).…”
Section: Musclesupporting
confidence: 84%
“…An increase in the connective tissue component of the myocardium occurs in a complex manner which may contribute to a n increase in the stiffness of the overloaded myocardium (Weber et al, 1987(Weber et al, , 1989Doering et al, 1988). The disproportionate increase in connective tissue that accompanied the pressure overload hypertrophy could be attenuated by a-or P-adrenoceptor blockade (Lauva et al, 1986). Both a-and P-adrenoceptor blockade failed to prevent and did decrease the amount of cardiac hypertrophy that resulted from pressure overload, and in particular this was true when heart muscle cell cross sectional areas were measured and used as a n index of the degree of hypertrophy 0 1991 WILEY-LISS, INC (Lauva et al, 1985).…”
mentioning
confidence: 99%
“…Multiple models mimicking RV pressure overload are available, including models of PH 7,8,9,10,11,12,13,14,15,16,17 and models of proximal RV pressure load 2,3,10,18,19,20,21,22,23 . The choice of either a model of PH or a model of proximal RV pressure load depends on the research question: the effect of an intervention on the pulmonary vasculature and therefore possibly RV afterload modulation (i.e., PH models), or the direct effect on the RV (i.e., proximal RV pressure load models).…”
Section: Introductionmentioning
confidence: 99%