Control of microbial contamination in unpreserved eyedrops.

Oldham, G. B.; Andrews, Victor

doi:10.1136/bjo.80.7.588

Cited by 32 publications

(21 citation statements)

References 13 publications

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“…19 Application of amniotic membrane suspension as eyedrops is a different approach for the treatment of alkali injures; however, its preservation is difficult. 20 Bonci et al in 2005 prepared a suspension containing homogenized amniotic membrane to investigate if it could have a beneficial effect on ocular surface diseases. They used this suspension to treat 21 patients with different ocular diseases.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Amniotic Membrane Suspension and Autologous Serum on Alkaline Corneal Epithelial Wound Healing in the Rabbit Model

Shahriari

Tokhmehchi

Reza

et al. 2008

Cornea

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Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Amniotic Membrane Suspension and Autologous Serum on Alkaline Corneal Epithelial Wound Healing in the Rabbit Model

Shahriari

Tokhmehchi

Reza

et al. 2008

Cornea

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“…However, hospital preparations have been reported to be associated with a high risk of microbial contamination. [3][4][5] In the present study, we evaluated the association of physicochemical properties such as pH and water activity with microbial contamination in ophthalmic preparations.…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, hospital preparations lacking preservatives have been reported to be associated with a high risk of microbial contamination. [3][4][5] However, there are various types of preparations produced in hospitals, and their physicochemical properties differ.…”

mentioning

confidence: 99%

The Risk of Microbial Contamination in Multiple-Dose Preservative-Free Ophthalmic Preparations

Saisyo

Shimono

Oie

et al. 2017

Biological & Pharmaceutical Bulletin

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Multiple-dose ophthalmic preparations that do not contain preservatives carry high risks of microbial contamination. However, there are various types of hospital preparations, with different physicochemical properties. In the present study, we evaluated the association between physicochemical properties and microbial contamination in ophthalmic preparations. The investigated hospital preparations included ophthalmic preparations of physiological saline, 0.2% fluconazole, 0.5% vancomycin hydrochloride, and 2% cyclosporine. We investigated the microbial dynamics of each ophthalmic preparation and microbial contamination in ophthalmic preparations used by patients. Remarkable growth of Pseudomonas aeruginosa, Burkholderia cepacia, and Serratia marcescens was observed in ophthalmic preparations of physiological saline and 0.2% fluconazole. All tested microorganisms displayed decreased counts after inoculation in 0.5% vancomycin hydrochloride. In 2% cyclosporine, all investigated microorganisms were below the limit of detection after inoculation for 6 h. The microbial contamination rates of ophthalmic preparations used by patients were 16.7% (3/18 samples) for 0.5% vancomycin hydrochloride and 0% (0/30 samples) for 2% cyclosporine. All detected contaminants in 0.5% vancomycin hydrochloride were Candida spp., one of which was present at a level of 1 10 4 colony-forming units/mL. The storage method for in-use ophthalmic preparations should be considered on the basis of their physicochemical properties.

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“…Some studies have evaluated and reported microbial contamination of preservative free eye-drops with extended use 7 8. The aim of the current study was to evaluate microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers after daily use.…”

mentioning

confidence: 99%

Microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers

et al. 2008

British Journal of Ophthalmology

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Control of microbial contamination in unpreserved eyedrops.

Cited by 32 publications

References 13 publications

Comparison of the Effect of Amniotic Membrane Suspension and Autologous Serum on Alkaline Corneal Epithelial Wound Healing in the Rabbit Model

Comparison of the Effect of Amniotic Membrane Suspension and Autologous Serum on Alkaline Corneal Epithelial Wound Healing in the Rabbit Model

The Risk of Microbial Contamination in Multiple-Dose Preservative-Free Ophthalmic Preparations

Microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers

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