Control of mandibular gland pheromone synthesis by alternative splicing of the CP-2 transcription factor gemini in honeybees (Apis mellifera carnica)

Jarosch-Perlow, Antje; Yusuf, Abdullahi Ahmed; Pirk, Christian Walter Werner; Crewe, Robin M.; Moritz, Robin F. A.

doi:10.1007/s13592-018-0571-5

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…The subsequently identified transcription factor gemini within the candidate locus on chromosome 13 is a key regulating gene for worker reproduction in general (Jarosch et al. 2011; Jarosch-Perlow et al. 2018) but does not control the mode of parthenogenesis per se (Chapman et al.…”

Section: Discussionmentioning

confidence: 99%

A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite

Aumer

Stolle

Allsopp

et al. 2019

Molecular Biology and Evolution

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The evolution of altruism in complex insect societies is arguably one of the major transitions in evolution and inclusive fitness theory plausibly explains why this is an evolutionary stable strategy. Yet, workers of the South African Cape honey bee ( Apis mellifera capensis ) can reverse to selfish behavior by becoming social parasites and parthenogenetically producing female offspring (thelytoky). Using a joint mapping and population genomics approach, in combination with a time-course transcript abundance dynamics analysis, we show that a single nucleotide polymorphism at the mapped thelytoky locus ( Th ) is associated with the iconic thelytokous phenotype. Th forms a linkage group with the ecdysis-triggering hormone receptor ( Ethr ) within a nonrecombining region under strong selection in the genome. A balanced detrimental allele system plausibly explains why the trait is specific to A. m. capensis and cannot easily establish itself into genomes of other honey bee subspecies.

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Section: Discussionmentioning

confidence: 99%

A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite

Aumer

Stolle

Allsopp

et al. 2019

Molecular Biology and Evolution

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“…Altering the splice pattern of gemini by siRNA feeding results in ovary activation and increased amount of queen-specific pheromones 9-oxo-2-decenoic acid (9-ODA) and 9-hydroxy-2-decenoic acid (9-HDA). As methyl p-hydroxybenzoate (HOB) and HVA are not affected by the knockdown of specific gemini , this gene possibly acts on the biosynthesis of fatty acid-derived components ( Jarosch et al, 2011 ; Jarosch-Perlow et al, 2018 ). The synthesis of QMP is also influenced by the sex determination pathway.…”

Section: Pheromonal Productionmentioning

confidence: 99%

Pheromonal Regulation of the Reproductive Division of Labor in Social Insects

Zhu

et al. 2020

Front. Cell Dev. Biol.

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The reproductive altruism in social insects is an evolutionary enigma that has been puzzling scientists starting from Darwin. Unraveling how reproductive skew emerges and maintains is crucial to understand the reproductive altruism involved in the consequent division of labor. The regulation of adult worker reproduction involves conspecific inhibitory signals, which are thought to be chemical signals by numerous studies. Despite the primary identification of few chemical ligands, the action modes of primer pheromones that regulate reproduction and their molecular causes and effects remain challenging. Here, these questions were elucidated by comprehensively reviewing recent advances. The coordination with other modalities of queen pheromones (QPs) and its context-dependent manner to suppress worker reproduction were discussed under the vast variation and plasticity of reproduction during colony development and across taxa. In addition to the effect of QPs, special attention was paid to recent studies revealing the regulatory effect of brood pheromones. Considering the correlation between pheromone and hormone, this study focused on the production and perception of pheromones under the endocrine control and highlighted the pivotal roles of nutrition-related pathways. The novel chemicals and gene pathways discovered by recent works provide new insights into the understanding of social regulation of reproductive division of labor in insects.

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“…Groups of workers (100) were placed in hoarding cages made of Perspex ® (Köhler et al, 2013) and reared in an incubator under conditions similar to those described above for brood rearing, for a period of 14 days. This was to allow enough time for the bees to activate their ovaries, as honey bee workers under queenless conditions are known to start activating their ovaries when they are as young as 10 days old (Velthuis, 1970;Ruttner and Hesse, 1981;Jarosch-Perlow et al, 2018).…”

Section: Experimental Cagesmentioning

confidence: 99%

Turning workers into false queens– the role of exogenous pheromones in regulating reproduction in worker honey bees

Yusuf

Crewe

Pirk

2018

Journal of Experimental Biology

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One of the responses that honey bee workers can make in the event of queen loss is to develop into false queens. False queens are workers that exhibit both behavioural and physiological traits similar to those of a true queen. However, the presence of more than one false queen in a colony distorts the established hierarchies. As transformation into a false queen occurs after emergence as an adult, we tested the effect of worker mobile pheromone carriers (PCs) treated with exogenously supplied pheromones on their nestmates. The PCs carried either synthetic mandibular gland pheromones or pheromones extracted from parasitic workers. Only the PCs attracted retinues of workers, increased pheromone production and activated their ovaries, becoming false queens. Pheromones from workers were more effective than extracts of commercially available synthetic queen pheromones in eliciting these effects. Using this simple mobile pheromone delivery system, we have shown that carrying amounts of exogenous pheromone can induce pheromone production in the carrier, resulting in the production of false queens within experimental groups. Possible implications of using this technique to modify and regulate worker reproduction in colonies are discussed.

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Control of mandibular gland pheromone synthesis by alternative splicing of the CP-2 transcription factor gemini in honeybees (Apis mellifera carnica)

Cited by 6 publications

References 34 publications

A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite

A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite

Pheromonal Regulation of the Reproductive Division of Labor in Social Insects

Turning workers into false queens– the role of exogenous pheromones in regulating reproduction in worker honey bees

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