Control of Malaria by Bio-Therapeutics and Drug Delivery Systems

Qaraghuli, Mohammed M. Al; Obeid, Mohammad A.; Aldulaimi, Omar; Ferro, Valerie A.

doi:10.4172/2161-0703.1000260

Cited by 6 publications

(3 citation statements)

References 90 publications

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“…Since then, liposomes have been established as vehicles for drug delivery [53] and have been extensively studied. Liposomes are the most studied lipid-based system investigated and have been the first to achieve clinical approval [47,54,55].…”

Section: Liposomesmentioning

confidence: 99%

Lipid-Based Nanomaterials in Cancer Treatment and Diagnosis

Obeid

Qaraghuli

Ruano

et al. 2022

Bionanotechnology: Next-Generation Therapeutic Tools

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Cancer consists of a wide range of diseases that are mainly driven by the continuous unregulated proliferation of cancer cells. Current treatment options include the use of chemotherapies, radiotherapy, and surgery. Recently, there was an increased interest in applying nanoparticles (NPs) in cancer diagnosis and treatment. NPs are materials in the size range 1 to 100 nm and can be classified based on their properties, shape, or size. They have attracted wide attention because of their versatile physicochemical properties, nanoscale sizes, high surface-to-volume ratios, favourable drug release profiles, and targeting modifications. Nanotechnology can be used to improve the personalisation of cancer diagnosis and treatment by enhancing the detection of cancer-specific biomarkers, imaging of tumours and their metastases, specific drug delivery to target cells, and real-time observation of treatment progression. This chapter will highlight the main types of lipid NPs with their preparation methods. The clinical applications of these lipid NPs in cancer diagnosis and treatment will be presented along with the currently approved drugs based on these NPs.

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Section: Liposomesmentioning

confidence: 99%

Lipid-Based Nanomaterials in Cancer Treatment and Diagnosis

Obeid

Qaraghuli

Ruano

et al. 2022

Bionanotechnology: Next-Generation Therapeutic Tools

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“…Consequently, these results encourage to test acrylamide hydrogels as antimalarial delivery systems.Processes 2019, 7, 396 2 of 12 risk of contracting this illness; in addition, according to the world Malaria report, nearly 800,000 people died in 2011 because of malaria, and most of them were children [1].The Increasing antimalarial resistant plasmodium strains has gained the attention of the World Health Organization (WHO) and its effort for eradication or elimination of this illness [2]. This fact, and the toxicity degree of antimalarials, represent a challenge for the scientific community; consequently, overcoming these two facts is a WHO goal of the millennium; however, it is obvious this goal demands multidisciplinary fronts, mainly related to efficient and rational strategies for new delivery systems as well as the development of new antimalarial drugs [2,3].Drug delivery systems that can control the release behaviors of multiple drugs have recently become an attractive route for enhanced therapeutic effects [4]. Hydrogels, lipids, and polymer-drug conjugate composites, have been studied as drug delivery systems on several illnesses [5,6].Regarding malaria, several studies about antimalarial-drug delivery have been reported, however, the liposome was one of the most effective systems [7].…”

mentioning

confidence: 99%

“…The Increasing antimalarial resistant plasmodium strains has gained the attention of the World Health Organization (WHO) and its effort for eradication or elimination of this illness [2]. This fact, and the toxicity degree of antimalarials, represent a challenge for the scientific community; consequently, overcoming these two facts is a WHO goal of the millennium; however, it is obvious this goal demands multidisciplinary fronts, mainly related to efficient and rational strategies for new delivery systems as well as the development of new antimalarial drugs [2,3].…”

mentioning

confidence: 99%

Theoretical Study of the Adsorption Process of Antimalarial Drugs into Acrylamide-Base Hydrogel Model Using DFT Methods: The First Approach to the Rational Design of a Controlled Drug Delivery System

et al. 2019

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The interaction between three widely used antimalarial drugs chloroquine, primaquine and amodiaquine with acrylamide dimer and trimer as a hydrogel model, were studied by means of density functional theory calculation in both vacuum and water environments, using the functional wb97xd with 6-31++G(d,p) basis set and polarizable continuum model (C-PCM) of solvent. According to binding energy, around −3.15 to −11.91 kJ/mol, the interaction between antimalarial compounds and hydrogel model are exothermic in nature. The extent of interaction found is primaquine > amodiaquine > chloroquine. The natural bond orbital (NBO) calculation and application of second-order perturbation theory show strong charge transfer between the antimalarial and hydrogel model. In addition, the results suggest these interactions are polar in nature, where hydrogen bonds play a principal role in stabilization of the complex. Comparing with the gas-phase, the complexes in the water environment are also stable, with suitable values of Log P (Partition coefficient), and dipolar momentum. Consequently, these results encourage to test acrylamide hydrogels as antimalarial delivery systems.

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