Control of Listeria innocua biofilms by biocompatible photodynamic antifouling chitosan based materials

Castro, Kelly A. D. F.; Moura, Nuno M. M.; Fernandes, Ana M.; Faustino, Maria A. F.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nakagaki, Shirley; Almeida, Adelaide; Cunha, Ângela; Silvestre, Armando J. D.; Freire, Carmen S.R.; Pinto, Ricardo J.B.; Neves, Maria G. P. M. S.

doi:10.1016/j.dyepig.2016.10.020

Cited by 41 publications

(34 citation statements)

References 59 publications

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“…Chitosan displays attractive properties to be used as a PS support such as its film-forming ability, biodegradability, and an inherent antimicrobial activity related with the protonated amino groups. The antimicrobial activity of this polymer can be improved through the covalent or non-covalent incorporation of bioactive materials/compounds like PS, phenolic compounds, antibiotics, and tetrahydrocurcominoid derivatives [ 30 , 106 , 107 , 108 , 109 , 110 , 111 ].…”

Section: Biopolymersmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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Microbial infection is a severe concern, requiring the use of significant amounts of antimicrobials/biocides, not only in the hospital setting, but also in other environments. The increasing use of antimicrobial drugs and the rapid adaptability of microorganisms to these agents, have contributed to a sharp increase of antimicrobial resistance. It is obvious that the development of new strategies to combat planktonic and biofilm-embedded microorganisms is required. Photodynamic inactivation (PDI) is being recognized as an effective method to inactivate a broad spectrum of microorganisms, including those resistant to conventional antimicrobials. In the last few years, the development and biological assessment of new photosensitizers for PDI were accompanied by their immobilization in different supports having in mind the extension of the photodynamic principle to new applications, such as the disinfection of blood, water, and surfaces. In this review, we intended to cover a significant amount of recent work considering a diversity of photosensitizers and supports to achieve an effective photoinactivation. Special attention is devoted to the chemistry behind the preparation of the photomaterials by recurring to extensive examples, illustrating the design strategies. Additionally, we highlighted the biological challenges of each formulation expecting that the compiled information could motivate the development of other effective photoactive materials.

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Section: Biopolymersmentioning

confidence: 99%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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“…This approach, although largely explored to functionalize the analogue 5,10,15,20-tetrakis(p entafluorophenyl)porphyrin, (Costa et al 2011b, Castro et al 2017) has also been envisaged for the functionalization of corrole 1 (Cardote et al 2012, Hori and Osuka 2010, Barata et al 2013. After a systematic evaluation of the experimental conditions, namely solvent type, temperature, base, number of equivalents of the nucleophile, it was verified that the best yields of the tris-substituted derivatives were obtained when the reactions were performed at room temperature under nitrogen, in DMSO and using K 2 CO 3 as the base.…”

Section: Resultsmentioning

confidence: 99%

“…(Lim et al 2012, Hwang et al 2012, Agadjanian et al 2009, Cardote et al 2012, Iglesias et al 2015, Barata et al 2013, Preuß et al 2014, Pohl et al 2014. According to that and following our interest in the development of tetrapyrrolic macrocycles with antibacterial activity, (Alves et al 2009, 2014b, Carvalho et al 2009, Costa et al 2012, Pereira et al 2012, Gomes et al 2013, Mesquita et al 2014a, b, Simões et al 2016, Lourenço et al 2015, Rocha et al 2015, Batalha et al 2015, Moura et al 2016, Castro et al 2017 we decided to synthesize the cationic corrole derivatives 2b and 3b and to study, for the first time, their efficiency in the PDI of Gram-negative bacteria. Herein, the synthesis, structural characterisation, photophysical properties (absorbance and singlet oxygen generation) and biological activity of the new cationic corroles against the naturally bioluminescent bacterium Allivibrio fischeri (A. fischeri) will be reported.…”

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confidence: 99%

Evaluation of meso-substituted cationic corroles as potential antibacterial agents

Cardote

Barata

Amador

et al. 2018

An. Acad. Bras. Ciênc.

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Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III) pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain.

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“…ZnO or copper nanoparticles in the surface of the coating can photocatalytically produce reactive oxygen species when irradiated by sunlight, resulting in oxidative stress and cell death [ 60 , 61 ]. Chitosan-porphyrin films will also produce reactive oxygen species, mainly singlet oxygen, to selectively kill microorganisms in the presence of light [ 62 ]. Some strong oxidizing agents, such as chlorine dioxide and juglone, can attack the thiol groups of biomolecules, interfering with various physiological processes essential for settlement [ 56 , 63 ].…”

Section: Antifouling Compounds With Proposed General Targetsmentioning

confidence: 99%

Review on Molecular Mechanisms of Antifouling Compounds: An Update since 2012

Chen

Qian

2017

Marine Drugs

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Better understanding of the mechanisms of antifouling compounds is recognized to be of high value in establishing sensitive biomarkers, allowing the targeted optimization of antifouling compounds and guaranteeing environmental safety. Despite vigorous efforts to find new antifouling compounds, information about the mechanisms of antifouling is still scarce. This review summarizes the progress into understanding the molecular mechanisms underlying antifouling activity since 2012. Non-toxic mechanisms aimed at specific targets, including inhibitors of transmembrane transport, quorum sensing inhibitors, neurotransmission blockers, adhesive production/release inhibitors and enzyme/protein inhibitors, are put forward for natural antifouling products or shelf-stable chemicals. Several molecular targets show good potential for use as biomarkers in future mechanistic screening, such as acetylcholine esterase for neurotransmission, phenoloxidase/tyrosinase for the formation of adhesive plaques, N-acyl homoserine lactone for quorum sensing and intracellular Ca2+ levels as second messenger. The studies on overall responses to challenges by antifoulants can be categorized as general targets, including protein expression/metabolic activity regulators, oxidative stress inducers, neurotransmission blockers, surface modifiers, biofilm inhibitors, adhesive production/release inhibitors and toxic killing. Given the current situation and the knowledge gaps regarding the development of alternative antifoulants, a basic workflow is proposed that covers the indispensable steps, including preliminary mechanism- or bioassay-guided screening, evaluation of environmental risks, field antifouling performance, clarification of antifouling mechanisms and the establishment of sensitive biomarkers, which are combined to construct a positive feedback loop.

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Control of Listeria innocua biofilms by biocompatible photodynamic antifouling chitosan based materials

Cited by 41 publications

References 59 publications

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Evaluation of meso-substituted cationic corroles as potential antibacterial agents

Review on Molecular Mechanisms of Antifouling Compounds: An Update since 2012

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