Control of Iron Delivery to Haemoglobin in Erythroid Cells

Ponka, P; Neuwirt, J; Borová, J; Fuchs, Ota

doi:10.1002/9780470720325.ch9

Cited by 16 publications

(15 citation statements)

References 64 publications

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“…Hasinoff et al 63 previously showed that ADR-925 and DEX displaced Fe from its calcein complex in solution. In our study, DEX removed Fe from the calcein in H9c2 cells, but was 4-fold less efficient than the well-characterized chelator, SIH, 33,65 and comparable results were also obtained with KH-TA4. The other analogues, MK-15, ES-5 and JR-159, instead reduced the cellular calcein fluorescence, which may be related to some interaction with calcein.…”

Section: Discussionsupporting

confidence: 77%

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

et al. 2015

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Section: Discussionsupporting

confidence: 77%

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

et al. 2015

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“…Because Tf-bound iron is efficiently used for heme synthesis (11,30) and no low M r cytoplasmic iron-transport intermediate has been found in reticulocytes, an intimate direct transfer of iron from Tf to the mitochondrion was proposed to occur (37,38). This idea has developed in more recent years and has led to the "kiss and run" hypothesis (11) (Fig.…”

Section: Regulation Of Cellular Iron Homeostasismentioning

confidence: 99%

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Richardson

Lane

Becker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

436

383

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The mitochondrion is well known for its key role in energy transduction. However, it is less well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for heme and iron sulfur cluster (ISC)-containing proteins involved in electron transport and oxidative phosphorylation, but also for a wide variety of cytoplasmic and nuclear functions, including DNA synthesis. The mitochondrial pathways involved in the generation of both heme and ISCs have been characterized to some extent. However, little is known concerning the regulation of iron uptake by the mitochondrion and how this is coordinated with iron metabolism in the cytosol and other organelles (e.g., lysosomes). In this article, we discuss the burgeoning field of mitochondrial iron metabolism and trafficking that has recently been stimulated by the discovery of proteins involved in mitochondrial iron storage (mitochondrial ferritin) and transport (mitoferrin-1 and -2). In addition, recent work examining mitochondrial diseases (e.g., Friedreich's ataxia) has established that communication exists between iron metabolism in the mitochondrion and the cytosol. This finding has revealed the ability of the mitochondrion to modulate whole-cell ironprocessing to satisfy its own requirements for the crucial processes of heme and ISC synthesis. Knowledge of mitochondrial ironprocessing pathways and the interaction between organelles and the cytosol could revolutionize the investigation of iron metabolism.iron sulfur cluster | heme | Friedreich's ataxia | frataxin | sideroblastic anemia

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“…17,66 However, HPCNH, HPCPH, HPC3AH and HPCIH in the presence of Fe II and H 2 O 2 stimulated plasmid degradation, leading to a marked decrease in SC DNA as the IBE increased to 3 (Fig. 9; lanes [9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Dna Plasmid Degradationmentioning

confidence: 99%

“…Fig 9. Typical plasmid Fe II -mediated degradation assay of EDTA, DFO and several HPCIH analogues (HPCNH, HPCPH, HPC3AH and HPCAH).…”

mentioning

confidence: 99%

Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity

et al. 2007

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Control of Iron Delivery to Haemoglobin in Erythroid Cells

Cited by 16 publications

References 64 publications

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity

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