Control of innate immune response by biomaterial surface topography, energy, and stiffness

Abaricia, Jefferson O.; Farzad, Negin; Heath, Tyler J.; Simmons, Jamelle; Morandini, Lais; Olivares-Navarrete, René

doi:10.1016/j.actbio.2021.04.021

Cited by 108 publications

(75 citation statements)

References 237 publications

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“…Their phenotypes are roughly divided into pro-inflammatory M1 and anti-inflammatory M2 phenotypes. M1 macrophages can secrete multiple cytokines to regulate chemotaxis, proliferation, and differentiation of immune cells as well as some progenitor cells, while M2 macrophages promote extracellular matrix (ECM) deposition, angiogenesis, and osteogenesis [ [25] , [26] , [27] , [28] , [29] ]. Fibroblasts have demonstrated multifaceted reparative effects.…”

Section: Introductionmentioning

confidence: 99%

Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response

Huang

Xie

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response

Huang

Xie

et al. 2023

Bioactive Materials

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“…In addition, uneven geometry as a result of the irregular porogen surface can lead to rough macro-scale topographies, potentially increasing the risk of pro-inflammatory responses. [58,59] To enhance control over both macro and microporosity, an alternative approach combined electrospinning with photoresist molds and laser drilling to achieve both high porosity and a niche-based cell spheroid distribution. [60,61] The resulting devices prevented islet aggregation and retained islet function.…”

Section: Optimized Implant Geometry To Improve Nutrient Transportmentioning

confidence: 99%

Integrating Additive Manufacturing Techniques to Improve Cell‐Based Implants for the Treatment of Type 1 Diabetes

Accolla

Simmons

Stabler

2022

Adv Healthcare Materials

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The increasing global prevalence of endocrine diseases like type 1 diabetes mellitus (T1DM) elevates the need for cellular replacement approaches, which can potentially enhance therapeutic durability and outcomes. Central to any cell therapy is the design of delivery systems that support cell survival and integration. In T1DM, well-established fabrication methods have created a wide range of implants, ranging from 3D macro-scale scaffolds to nano-scale coatings. These traditional methods, however, are often challenged by their inherent limitations in reproducible and discrete fabrication, particularly when scaling to the clinic. Additive manufacturing (AM) techniques provide a means to address these challenges by delivering improved control over construct geometry and microscale component placement. While still early in development in the context of T1DM cellular transplantation, the integration of AM approaches serves to improve nutrient material transport, vascularization efficiency, and the accuracy of cell, matrix, and local therapeutic placement. This review highlights current methods in T1DM cellular transplantation and the potential of AM approaches to overcome these limitations. In addition, emerging AM technologies and their broader application to cell-based therapy are discussed. Cellular Implants for the Treatment of Type 1 DiabetesCell-based therapies provide a potential curative approach for resolving type 1 diabetes mellitus (T1DM) via the replacement of the insulin-producing cells lost to autoimmune destruction. [1][2][3] In the native pancreas, these insulin-producing cells, termed 𝛽-cells, work to modulate metabolism and blood sugar in

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“…Mechanical properties of biomaterials could affect the modulation of cell/immune response and thus the outcome of the in vivo experiments. [42][43][44] Therefore, the design of hydrogels with appropriate mechanical properties would contribute to positive and improved therapeutic outcomes. Hydrogel viscosity decreased dramatically as the shear rate increased from 0.01 to 100 s -1 (Figure 2H).…”

Section: Hydrogel Synthesis and Characterizationmentioning

confidence: 99%

An Injectable Antibiotic Hydrogel that Scavenges Proinflammatory Factors for the Treatment of Severe Abdominal Trauma

Yang

Dawulieti

Zhang

et al. 2022

Adv Funct Materials

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Bacterial infection and excessive inflammation following abdominal injury can cause life-threatening complications that lead to multiple organ failure and death. Removing bacteria and proinflammatory factors-which are predominantly negatively charged-from the wound site with a cationic, antibiotic-containing hydrogel wound dressing is therefore a promising treatment approach for severe abdominal trauma. Here an injectable, self-healing hydrogel composed of the gel-forming glycosaminoglycan oxidized chondroitin sulfate (OCS), cationic polyethylenimine (PEI), and the antibiotic tobramycin (Tob) via a Schiff's base reaction is developed. Compared with hydrogels lacking either PEI or Tob, only the Tob/PEI/OCS hydrogels exhibit a large binding capacity for negatively-charged proinflammatory factors including cell-free DNA, lipopolysaccharides, TNF-α, and high mobility group box 1 protein, and a large reduction in bacterial populations in vitro. In a murine model of severe abdominal trauma, the Tob/PEI/OCS hydrogel exhibits good biodegradability and biosafety, reduced local and systemic inflammation and infection, and prevents multiple organ failure, resulting in 100% survival. This hydrogel dressing is thus a promising biomaterial for preventing complications and improving outcomes following severe abdominal trauma.

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Control of innate immune response by biomaterial surface topography, energy, and stiffness

Cited by 108 publications

References 237 publications

Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response

Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response

Integrating Additive Manufacturing Techniques to Improve Cell‐Based Implants for the Treatment of Type 1 Diabetes

An Injectable Antibiotic Hydrogel that Scavenges Proinflammatory Factors for the Treatment of Severe Abdominal Trauma

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