Control of human vascular tone by prostanoids derived from perivascular adipose tissue

Özen, Gülsev; Topal, Gökçe; Gomez, Ingrid; Ghorreshi, Arézou; Boukais, Kamel; Benyahia, Chabha; Kanyinda, Larry; Longrois, Dan; Teskìn, Önder; Uydeş-Doğan, B. Sönmez; Norel, Xavier

doi:10.1016/j.prostaglandins.2013.06.002

Cited by 53 publications

(39 citation statements)

References 27 publications

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“…PVAT surrounding the internal thoracic artery and saphenous vein significantly attenuate the response to vasoconstrictor agents compared with those contractions elicited in vessels cleaned of PVAT [11]. However, these mechanisms are regionally different, since saphenous vein PVAT attenuates norepinephrine-induced contraction by releasing both prostaglandin E2 (PGE 2 ) and prostacyclin (PGI 2 ), whereas internal thoracic artery PVAT exerts its anticontractile effect independently from prostanoids [13]. Moreover, PVAT surrounding the brachial artery is independently associated with insulin sensitivity but unrelated to endothelial dysfunction [14].…”

mentioning

confidence: 99%

Regional differences in perivascular adipose tissue impacting vascular homeostasis

Gil‐Ortega¹,

Somoza²,

Huang³

et al. 2015

Trends in Endocrinology & Metabolism

113

103

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mentioning

confidence: 99%

Regional differences in perivascular adipose tissue impacting vascular homeostasis

Gil‐Ortega¹,

Somoza²,

Huang³

et al. 2015

Trends in Endocrinology & Metabolism

113

103

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“…In IMA, the presence of PVAT reduces the contractile responses to both phenylephrine/norepinephrine and also U46619 (thromboxane mimetic) (Gao et al, 2005;Ozen et al, 2013). Another study also confirmed that PVAT of IMA attenuates the contractile response to serotonin and angiotensin II (Malinowski et al, 2013).…”

Section: Role Of Pvat In Vascular Tone Control In Vitromentioning

confidence: 84%

“…In SV, it has also been demonstrated that PVAT reduces the contractile response or sensitivity to NE/serotonin (Ford et al 2006;Ozen et al, 2013). Contrary to IMA, incubation with indomethacin decreases vasorelaxant effect of PVAT in SV.…”

Section: Role Of Pvat In Vascular Tone Control In Vitromentioning

confidence: 99%

“…and IP receptor, respectively (Foudi et al, 2011;Ozen et al, 2013). Other research groups have shown the presence of endothelial nitric oxide synthase (eNOS) activity (Dashwood et al, 2007), the release or expression of leptin (Dashwood et al, 2011) and adiponectin (Margaritis et al, 2013) in the PVAT of human SV.…”

Section: Role Of Pvat In Vascular Tone Control In Vitromentioning

confidence: 99%

“…Another study also confirmed that PVAT of IMA attenuates the contractile response to serotonin and angiotensin II (Malinowski et al, 2013). In contrast to gluteal PVAT, the vasorelaxant effect of PVAT in IMA is not abolished in the presence of NOS inhibitor or COX inhibitor (indomethacin), which inhibits the production of PGI 2 (Malinowski et al, 2008;Ozen et al, 2013). However, incubation with a calcium-dependent potassium channel blocker abolishes the relaxing effect of PVAT in IMA preparations (Gao et al, 2005;Malinowski et al, 2008;Malinowski et al, 2013).…”

Section: Role Of Pvat In Vascular Tone Control In Vitromentioning

confidence: 99%

See 2 more Smart Citations

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling

Özen

Daci

Norel

et al. 2015

European Journal of Pharmacology

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3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation‐Induced Vein Graft Failure

Wang

Xiao

et al. 2023

Adv Healthcare Materials

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Clinically, arterial injuries are always accompanied with perivascular tissue damage, which may contribute to high failure rate of vein grafts due to intimal hyperplasia and acute thrombosis. In this study, a “perivascular tissue (PVT) deprivation” animal model is constructed to mimic clinical scenarios and identify the contribution of arterial PVT to the success of vein grafts. Proteomics analysis suggests that depriving PVT may exacerbate reactive oxygen species (ROS)‐induced endothelial apoptosis by up‐regulating inflammation response and oxidative stress. Locally administering metformin on vein grafts through 3D‐printed external stent (PGS‐PCL) shows antioxidative and anti‐inflammatory properties to protect cells from ROS invasion, thereafter decreasing acute thrombosis. Moreover, metformin induce rapid regeneration of perivascular adipose tissue in recipient regions, which improves patency by inhibiting intimal hyperplasia. Proteomics, western blot, and in vitro blocking tests reveal that metformin resists endothelial apoptosis through AMPK/mTOR and NFκB signaling pathways. To conclude, PVT deprivation exacerbates inflammatory response and oxidative stress in vein grafts bridging arterial circulation. Metformin‐loaded stent ameliorates “PVT damage” related vein graft failure, and enhances patency of through resisting endothelial apoptosis and regenerating arterial PVAT, offering a promising avenue to improve the success of vein grafts in clinic.

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Control of human vascular tone by prostanoids derived from perivascular adipose tissue

Cited by 53 publications

References 27 publications

Regional differences in perivascular adipose tissue impacting vascular homeostasis

Regional differences in perivascular adipose tissue impacting vascular homeostasis

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling

3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation‐Induced Vein Graft Failure

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