Control of Heparin Surface Density in Multilayers of Partially Hydrolyzed Poly(2-ethyl-2-oxazoline) by Degree of Hydrolysis
Ghazaleh Azizi Saadatlou,
Pinar Tatar Guner,
A. Levent Demirel
Abstract:Controlling the surface density of heparin in active anticoagulant coatings is important in applications where an optimum is required. An approach based on tuning the degree of hydrolysis of poly(2-ethyl-2-oxazoline) (PEOX) is presented to control the surface density of heparin in layer-by-layer (LbL) assembled films. Multilayers are prepared at pH5 in 0.5M aqueous NaCl solutions by electrostatic interactions between negatively charged heparin and the positively charged amine groups in hydrolyzed PEOX. Charact… Show more
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