Control of hematopoietic cell growth regulators during mouse fetal development.

Azoulay, Martine; Webb, Cynthia; Sachs, Leo

doi:10.1128/mcb.7.9.3361

Cited by 46 publications

(15 citation statements)

References 33 publications

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“…CSF-1 is also found in placenta, amniotic fluid, and at low concentrations in the fetus (5,20,21). CSF-1 mRNA is restricted to the luminal and glandular epithelium throughout pregnancy, indicating that the CSF-1 detected in the placenta and amniotic fluid is synthesized in the uterus.…”

Section: Discussionmentioning

confidence: 99%

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Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development.

Arceci

Shanahan

Stanley

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

242

119

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During pregnancy the mouse uterine epithelial synthesis of the mononuclear phagocyte growth factor designated colony-stimulating factor 1 (CSF-1) is regulated by female sex steroids. To study the role of CSF-1 in the pregnant female reproductive tract, the temporal expression and cellular sites of synthesis of CSF-1 and CSF-1 receptor (CSF-1R) mRNA were determined. CSF-1 mRNA, predominantly the 2.3-kilobase (kb) form, was first detected by in situ hybridization in uterine epithelium prior to implantation on day 3 and subsequently increased, reaching a peak at days 14-15.

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Section: Discussionmentioning

confidence: 99%

“…While CSF-1 mRNA has been detected in placental samples by Northern blotting (6,20), both in situ studies failed to detect significant placental CSF-1 mRNA. This suggests that the detection of "placental" CSF-1 mRNA by Northern blotting was due to uterine contamination of placental samples.…”

mentioning

confidence: 98%

Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development.

Arceci

Shanahan

Stanley

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

242

119

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“…Daiter et al [12] and Saito et al [13] reported similar findings. In contrast to M-CSF, CA 125 reaches high levels among pregnant women, espe cially in the first trimester [8,14,15], Azoulay et al [16] reported that M-CSF is produced in the placenta and embryonic membrane of mice. Pollard et al [17] reported that it is produced in the uterine glandular epithelium of mice.…”

Section: Discussionmentioning

confidence: 99%

Serum Level of Macrophage Colony–Stimulating Factor as a Marker for Gynecologic Malignancies

Suzuki

Ohwada²,

Sato³

et al. 1995

Oncology

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We determined the serum levels of macrophage colony-stimulating factor (M-CSF) in 441 women with gynecologic diseases to evaluate its role as a marker for gynecologic malignancy. Serum M-CSF levels were above the normal baseline level of 1,056 U/ml in 64% (56/88) of patients with ovarian cancer, 27% (16/60) of those with cervical cancer, and 25% (15/61) of those with endometrial cancer. M-CSF was significantly elevated in the serum of patients with advanced as compared with early stage cancer (stage I) of the ovary (p < 0.01), cervix (p < 0.05), and endometrium (p < 0.05). Only 5.6% of the patients with benign ovarian tumors and 7.0% of those with endometrial cysts had serum levels of M-CSF that exceeded 1,056 U/ml. M-CSF was localized in the glandular epithelial cells as well as in the stromal macrophages and the endothelial cells of the ovarian cancers. M-CSF thus appeared to be a marker with high specificity for ovarian cancer.

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“…Besides hematopoiesis, the secondary yolk sac is an active site of protein biosynthesis and nutrient transport [90,94]. The endodermal component of the primate secondary yolk sac is a known transporter of proteins and vitamins [95][96][97].…”

Section: Yolk-sac Formation Differs In Man and Mousementioning

confidence: 99%

Yolk-sac hematopoiesis

Palis

Yöder

2001

Experimental Hematology

379

272

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Objective. To review the process of blood-cell formation in the murine and human yolk sac. Data Sources. Most articles were selected from the PubMed database. Data Synthesis. The yolk sac is the first site of blood-cell production during murine and human ontogeny. Primitive erythroid cells originate in the yolk sac and complete their maturation, including enucleation, in the bloodstream. Though species differences exist, the pattern of hematopoietic progenitor cell emergence in the yolk sac is similar in mouse and man. In both species, there is a stage of development where both primitive red blood cells and definitive erythroid progenitors are produced in the yolk sac. An "embryonic" hematopoietic stem cell that engrafts in myeloablated newborn but not adult mice can be detected in the murine yolk sac and embryo. Stem-cell activity in the human yolk sac has not been reported. Conclusions. The yolk sac is the sole site of embryonic erythropoiesis. However, definitive erythroid, myeloid, and multipotential progenitors also originate in the yolk sac. The relationship between these progenitors and the "embryonic" hematopoietic stem cell has not been elucidated. Yolk sac-derived progenitor cells may seed the developing liver via the circulation and serve as the immediate source of the mature blood cells that are required to meet the metabolic needs of the rapidly growing fetus.

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Control of hematopoietic cell growth regulators during mouse fetal development.

Cited by 46 publications

References 33 publications

Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development.

Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development.

Serum Level of Macrophage Colony–Stimulating Factor as a Marker for Gynecologic Malignancies

Yolk-sac hematopoiesis

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