Control of food intake during continuous injection of glucose into the upper duodenum and the upper ileum of rats

Glick, Z.; Modan, Michaela

doi:10.3758/bf03335290

Cited by 30 publications

(3 citation statements)

References 19 publications

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“…In studies performing acute tests, other authors have reported that lipid infusions into the duodenum in rats (16,25) and jejunum in human subjects (23) suppressed intake in excess of caloric load. In multiple-day studies on rats, similar effects on intake were reported by Glick and Modan (7) and Burton-Freeman and Schneeman (3). The former authors infused soybean oil continuously into the duodenum or ileum for 3-8 days and found infusions at these two sites to be equally effective in suppressing intake.…”

Section: Discussionsupporting

confidence: 76%

“…If sustained with repeated dosing, this effect has obvious potential for promoting weight loss, although little evidence is available for evaluating this possibility. In multiple-day studies on rats, both negative (7) and positive results (3) have been reported. In the experiments described below, adult, male Sprague-Dawley rats received slow jejunal infusions of free linoleic or oleic acid on either 4 or 21 consecutive days.…”

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confidence: 99%

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Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

Cox

Tyler

Randich

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumption of the liquid diet Boost, Mead Johnson, plus load) by approximately 15% and decreased weight gain compared with 4-day tests with saline administration. In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffective, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusions of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared with controls receiving saline. The net decrease in caloric intake may reflect the combined activation of pre- and postabsorptive mechanisms, and it suggests a possible treatment for obesity.

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Section: Discussionsupporting

confidence: 76%

mentioning

confidence: 99%

Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

Cox

Tyler

Randich

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In general, all of these studies reported that the enteral administration (stomach, duodenum, etc.) of nutrients leads to a reduction in subsequent intake, which has been interpreted as evidence of its satiating effect (Kohn 1951;Berkun et al 1952;Glick and Modan 1977;Novin et al 1979;Canbely and Koopmans 1984;Chapman et al 1999;Reidelberger et al 2003;Cox et al 2004). …”

Section: Introductionmentioning

confidence: 99%

Lesions of the lateral parabrachial area block the aversive component and induced-flavor preference for the delayed intragastric administration of nutrients in rats: Effects on subsequent food and water intake

Zafra¹,

Simon²,

Molina³

et al. 2005

Nutritional Neuroscience

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The aim of this study was to examine the function of the lateral parabrachial area (LPB) in relation to the intragastric administration of nutrients. The consumption of flavors associated with intragastric nutrient administration and the subsequent food and water intake were measured in rats with lesions in the LPB. The results showed that bilateral LPB lesions prevented development of aversions and induced flavor preference when there was a delay between the presentation of a flavor and the intragastric administration of nutrients. However, these lesions did not disrupt development of the aversive process when there was no delay between the presentations. Likewise, the LPB lesions increased subsequent food intake when there was a delay but not when there was no delay between the presentations. In contrast, the water intake was reduced in both situations. These results are interpreted in terms of a dual visceral system for processing the intragastric effects of foods.

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Behavioral compensatory responses to continuous duodenal and upper ileal glucose infusion in rats

Glick

Modan

1977

Physiology & Behavior

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Control of food intake during continuous injection of glucose into the upper duodenum and the upper ileum of rats

Cited by 30 publications

References 19 publications

Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

Lesions of the lateral parabrachial area block the aversive component and induced-flavor preference for the delayed intragastric administration of nutrients in rats: Effects on subsequent food and water intake

Behavioral compensatory responses to continuous duodenal and upper ileal glucose infusion in rats

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