Control of Enuresis With Imipramine

Margolis, Lester H.

doi:10.1176/ajp.119.3.269

Cited by 20 publications

(3 citation statements)

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“…Use of placebo was thought to be unnecessary since previous use of tranquillizers had been ineffective; this is a doubtful assertion. Margolis (21) in another uncontrolled investigation reported immediate relief of enuresis in three children aged eight, nine and 12t years. Schunzelaar (32), in a group of 20 chronic hospitalized patients who were mostly psychotic, aged 34-81 years, using a dosage of 50-100 mgm.…”

Section: Discussionmentioning

confidence: 97%

Imipramine in the Treatment of Nocturnal Enuresis of Childhood

Alderton

1965

Canadian Psychiatric Association Journal

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A double-blind study of the use of imipramine in the treatment of nocturnal enuresis is reported. The subjects were twelve children aged six to 12 years in a children's psychiatric hospital. The drug (25 mg) or placebo was administered at 8.00 p.m. for two or four weeks at a time, the trial extending from 16 weeks to 32 weeks. For the group as a whole, the number of enuretic nights declined from 46.75% on placebo to 31.75% on drug, a reduction of 32.09%. The average enuresis per child declined from 47.25% to 30.75%, a reduction of 34.92%. Three children showed a significant response to placebo, one of these became virtually dry. Seven of the subjects showed a signficant response to the drug, with reduction of enuretic nights of 25% or more in all, of 50% or more in three and of 70% or more in two. Relapse occurred on discontinuing the drug. In addition to the fall in enuresis each time drug was given, an over-all decrease in enuresis occurred throughout the trial, not due to spontaneous improvement. It is suggested that this results from the full effects of the drug being somewhat delayed and taking some time to wear off. Observations on the time at which enuresis occurred showed that most commonly only incidents after 1 a.m. were reduced, suggesting that for this group earlier administration of the drug may be desirable. In only one subject was enuresis before 1 a.m. accompanied by an increase in incidents after 1 a.m. and for such cases an increased dosage may be effective. No side effects from the drug were observed. A consideration of the mode of action of the drug is presented and it is concluded that it may act by diminishing uninhibited bladder contractions by its autonomic diencephalic action. Previous reports on the treatment of enuresis by imipramine are reviewed together with a brief review of controlled studies of other drugs which have appeared in the past decade. It is concluded that imipramine is a useful drug in the treatment of enuresis in psychiatrically disturbed children.

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Section: Discussionmentioning

confidence: 97%

Imipramine in the Treatment of Nocturnal Enuresis of Childhood

Alderton

1965

Canadian Psychiatric Association Journal

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“…Two were uncontrolled: Margolis (24) There was no significant difference between the two groups. Reca and Schiff (35) experimented with twenty-five children age 3-13.…”

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confidence: 91%

“…Noack (32) studied forty-four children and Poussaint and Ditman (34) studied fifty-four children (ages 5-16) and both found imipramine statistically superior to placebos in treating enuretic symptoms. On the negative side, Treffert (40), in double-blind study, found nine patients aged 6-18 did not do better on imipramine than placebos; Blackman and Benton (3) studied thirty-five army recruits (ages [17][18][19][20][21][22][23][24][25] and with a dose of 50 mg. reported imipramine was no more effective than a placebo or no medication; and Hicks and Barnes (19) studied 100 naval recruits in a double-blind study and found no difference between imipramine and placebo. The dose in this latter study was 25 mg. which prompted a letter from Leon Tee, M.D.…”

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confidence: 99%