Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

Pourquié, Olivier; Coltey, M; Teillet, Marie-Aimée; Ordahl, Charles P.; Douarin, Nicole M. Le

doi:10.1073/pnas.90.11.5242

Cited by 279 publications

(151 citation statements)

References 23 publications

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“…Removal of the notochord at stage 10 prevents later floor plate and ventral neuronal differentiation (31), while conversely, notochord grafts (stages 10-12) placed adjacent to the neural tube induce ectopic floor plate and ventral neuron differentiation 2 days later (32). In addition, it has been shown that, in vivo, the notochord and the floor plate possess also a dorsoventral polarizing activity on the paraxial mesoderm (somites) (42). The dorsal part of the somites will segregate into the dermomyotome (which will yield the striated muscles and dermis) and the ventral part will segregate in the sclerotome (which will yield the vertebrae, the intervertebral disks, and ribs).…”

Section: Discussionmentioning

confidence: 99%

Olfaction: Transient expression of a putative odorant receptor in the avian notochord

Nef

Nef²

1997

Proc. Natl. Acad. Sci. U.S.A.

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In vertebrates, odors are thought to be detected by a multigene family encoding several hundreds of seventransmembrane-domain G-protein-coupled receptors found in fish, rat, mouse, dog, and human. Recently, the putative odorant receptor (OR) gene family in the chicken has been characterized. Twelve members have been isolated and subdivided into six subfamilies. Herein, we have further characterized the chicken olfactory receptor subfamily 7 (COR7) composed of two highly related genes (named COR7a and COR7b) which are 98.5% identical. By in situ hybridization experiments, both COR7a and COR7b transcripts were detected in the olfactory epithelium from embryonic day 6 (E6) to the new born stage. Within the olfactory epithelium, the spatial distribution of COR7a and COR7b labeled cells was random. We also observed that every individual positive cell did not coexpress the COR7a and COR7b genes. Interestingly, the COR7b gene was found to be transiently expressed in the notochord from E2 to E6, whereas COR7a or any of the other known members of the COR gene family were not detected in this mesodermal tissue. These data suggest that, in addition to its potential role as an OR in the olfactory system, COR7b may also have a function in the notochord that is essential for the dorsoventral organization of the neural tube and of the somitic mesoderm. We also discuss the possible role(s) of a putative OR present in both the notochord and the sensory olfactory epithelium.

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Section: Discussionmentioning

confidence: 99%

Olfaction: Transient expression of a putative odorant receptor in the avian notochord

Nef

Nef²

1997

Proc. Natl. Acad. Sci. U.S.A.

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“…The notochord is a midline mesodermal embryonic structure common to all members of the phylum chordata, which has essential functions in patterning the paraxial mesoderm (Herrmann et al, 1990;Dietrich et al, 1993;Pourquie et al, 1993), the neuroectoderm (van Straaten et al, 1988;Bovolenta and Dodd, 1991;Yamada et al, 1993;Placzek et al, 1993), and other tissues (Wiertz-Hoessels et al, 1987;Stern et al, 1991;Danos and Yost, 1995), through notochord-derived signals. In the zebrafish (Danio rerio), systematic mutational analysis of early development has identified several notochord-expressed genes, such as no tail (ntl) and floating head (flh) (Halpern et al, 1993;SchulteMerker et al, 1994;Talbot et al, 1995;Odenthal et al, 1996;Stemple et al, 1996;Currie and Ingham, 1996;Fouquet et al, 1997;Blagden et al, 1997;Amacher and Kimmel, 1998), in which loss-of-function mutations cause defects in the formation and/or maintenance of the notochord and within other tissues.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of Calymmin, a novel notochord sheath‐associated extracellular matrix protein in the zebrafish embryo

Cerdà

Gründ

Franke

et al. 2002

Developmental Dynamics

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During the screening of a zebrafish postsomitogenesis embryo cDNA library, we have identified a cDNA corresponding to a novel type of protein localized to the notochordal sheath-associated extracellular matrix (ECM) of the embryo. The 4.049-kb mRNA encodes a predicted polypeptide of 1,207 amino acids (122 kDa, pI 10.50) with a potential signal peptide of 20 amino acids. After the signal peptide, the mature protein consists of 1,187 amino acids (119 kDa, pI 10.46), for which the name "Calymmin" (from Greek ␣ ␣, to envelop, to cover) is proposed. The Calymmin mRNA is highly and transiently expressed by the notochord cells of the embryo from the 10-to 12-somite stage to the pharyngula period (13 and 24 hours postfertilization, respectively), and light and electron microscopical immunolocalization analysis revealed that the protein was specifically localized within a granular and filamentous layer of the ECM compartment surrounding the notochord. In zebrafish no tail mutants (ntl tc41 ), in which the notochord precursor cells are present but fail to differentiate, the Calymmin protein was not detected, confirming the notochord origin of Calymmin. These results indicate that Calymmin is a novel constitutive protein of the ECM compartment associated to the perinotochordal sheath in the zebrafish embryo, which is specifically expressed by the differentiating notochord cells.

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“…In the neuroepithelium, the notochord contributes to and induces the formation of the floor plate (Placzek et al, 1993;Placzek et al, 1990;Placzek et al, 1991), and is an important inducer of motor neurons (Tanabe and Jessell, 1996). The notochord also plays a key role during sclerotomal development Brand-Saberi et al, 1993;Koseki et al, 1993;Pourquie et al, 1993), from which the bones, cartilage, and connective tissue of the axial skeleton are derived (reviewed in Christ and Wilting, 1992).…”

Section: Formation Of the Primitive Streak And The Notochordmentioning

confidence: 99%

“…Notochord ablation and transplantation experiments in the chick and analyses of mouse notochord mutants have demonstrated that the notochord participates in the specification of ventral sclerotome derivatives (BrandSaberi and Christ, 2000;Brand-Saberi et al, 1993;Dietrich et al, 1993;Goulding et al, 1993;Koseki et al, 1993;Pourquie et al, 1993). Ablation of the notochord leads to the loss of ventral sclerotome derivatives.…”

Section: From Sclerotome To Mesenchymal Prevertebraementioning

confidence: 99%

Molecular basis for skeletal variation: insights from developmental genetic studies in mice

Kappen

Neubüser

Balling

et al. 2007

Birth Defects Research Pt B

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Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development. Birth Defects Res (Part B), 80:425–450, 2007. © 2007 Wiley‐Liss, Inc.

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Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

Cited by 279 publications

References 23 publications

Olfaction: Transient expression of a putative odorant receptor in the avian notochord

Olfaction: Transient expression of a putative odorant receptor in the avian notochord

Molecular characterization of Calymmin, a novel notochord sheath‐associated extracellular matrix protein in the zebrafish embryo

Molecular basis for skeletal variation: insights from developmental genetic studies in mice

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