Control of coronary intercapillary distance: Effect of arterial PCO2 and pH

Bourdeau-Martini, J; Honig, Carl R.

doi:10.1016/0026-2862(73)90077-0

Cited by 20 publications

(5 citation statements)

References 14 publications

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“…It is possible that in some organs, such as the cerebral cortex, a change in capillary distance produced in this manner permits a more economic O 2 supply. These factors also have been discussed (Bourdeau-Martini and Honig, 1973 lary. The ideal capillary pattern is one in which there is asymmetric arrangement, together with a high degree of tortuosity with multiple arterial inputs.…”

Section: Discussionmentioning

confidence: 99%

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Chang¹,

Yamakawa²,

Nuccio³

et al. 1982

Circulation Research

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By means of transillumination (microtransilluminator and light pipe), comparative analyses were carried out on geometry, topography, and morphometry of microcirculation in the cerebral cortex, left atrial muscle, and mesentery of the cat using computer analysis. In addition, specific types of capillary distribution (concurrent, countercurrent, and asymmetric distribution) in these three organs were ascertained from images visualized on films. These parameters were related to their role in tissue oxygen supply. It was found that mean capillary diameter, mean intercapillary distance, total capillary length, and total capillary surface area differed significantly among the three organs. Differences in mean capillary tortuosity between cerebral cortex and left atrial muscle and between left atrial muscle and mesentery also were significant. Mean capillary tortuosity in mesentery and cerebral cortex was of equal magnitude. In the cerebral cortex, a high degree of tortuosity and asymmetric capillary distribution favor tissue oxygenation. A similar situation exists in left atrial muscle, although some concurrent and countercurrent distribution could be detected. In the mesentery, the combination of high capillary tortuosity and concurrent capillary arrangement is unfavorable for tissue oxygenation. Cirv Res 50: 240-249, 1982 IT IS the function of the capillaries to maintain tissue oxygenation constantly and to respond rapidly to changing oxygen demands (Hall

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Section: Discussionmentioning

confidence: 99%

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Chang¹,

Yamakawa²,

Nuccio³

et al. 1982

Circulation Research

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“…It is reassuring that the study of Harris et al (115) on bat wing microvessels suggests that the neural component is minor. Over the past ten years Honig and his collaborators have convincingly shown that reduced arterial Po2 decreases intercapillary distance (28,29,195). These investigators have proposed that reduced tissue Po2 causes the precapillary sphincters to open, either by a direct effect on sphincter smooth muscle (140) as described in section OSMOLARITY; subsection SKELETAL MUSCLE, or by causing the release of a vasodilator metabolite.…”

Section: Effectmentioning

confidence: 99%

Effect of Local Metabolic Factors on Vascular Smooth Muscle

Sparks

1980

Comprehensive Physiology

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“…With regard to the second possibility of an increased open capillary density with increased arterial Pco2, Bourdeau-M artini and H onig [3] have reported no increase. Direct enumeration of the number of open capillaries on the surface of the heart shows no significant changes over the range of arterial Pco2 from 40 to 60 mm Hg in anesthetized open chest rats.…”

Section: Discussionmentioning

confidence: 99%

“…There are several major differences in the studies that could account for the dis crepancies in results. B o u r d e a u -M a r tin i and H o n ig [3] observed sur face capillaries of the heart, while we studied the total myocardial capil lary pool. Intramyocardial pressure increases with depth into the left ventricle [2], This pressure provides an extravascular component to im pede coronary blood flow especially during systole.…”

Section: Discussionmentioning

confidence: 99%

Changes in Small Vessel Blood Content of the Rat Heart Induced by Hypercapnic, Hyperoxic or Asphyxic Conditions

Weiss¹,

Cohen²

1978

Cardiology

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The small vessel blood content (SVBC) of the ventricular walls of the heart of anesthetized closed chest rats was determined using ⁵⁹FeCl₃ to label the plasma siderophilin. SVBC was measured breathing air, 100% O_2’, 5% CO_2’ in 21% O_2’ and during asphyxia. The average SVBC could be ranked: air < 100% O_2’ < 5% CO₂ < asphyxia. Only the ‘100% O₂’ values were not significantly above the ‘air’ values. Under control conditions, SVBC of the rat heart averaged 6.77 ± (SE) 0.23 ml blood/100 g tissue. Inhalation of 5% CO₂ increased this to 8.68 ± 0.34, while asphyxia produced a maximal response to 14.40 ± 0.77. Comparison of SVBC were made between various regions of the ventricular walls. The only significant difference was that the right side of the septum had a lower SVBC than the left ventricular sub-epicardium under all conditions except CO₂. These differences in SVBC are related to the number of open capillaries in the myocardium. Thus inhalation of CO₂ decreases intercapillary distance while 100% O₂ has no effect.

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Control of coronary intercapillary distance: Effect of arterial PCO2 and pH

Cited by 20 publications

References 14 publications

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. A comparative analysis.

Effect of Local Metabolic Factors on Vascular Smooth Muscle

Changes in Small Vessel Blood Content of the Rat Heart Induced by Hypercapnic, Hyperoxic or Asphyxic Conditions

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