Control of clinical coccidiosis of calves due to Eimeria bovis and Eimeria zuernii with toltrazuril under field conditions

Mundt, Hans-Christian; Bangoura, Berit; Mengel, H.; Keidel, J.; Daugschies, Arwid

doi:10.1007/s00436-005-1457-9

Cited by 58 publications

(38 citation statements)

References 3 publications

(10 reference statements)

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“…Eimeria bovis and E. zuernii were reported here and they are noted as the most pathogenic species of Eimeria affecting cattle. Even low infectious doses of E. bovis oocysts (10 4 ) and E. zuernii (10 5 ) result in severe haemorrhagic enteritis with weight losses, dehydration or death of heavily infected animals (Mundt et al, 2005;Hermosilla et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Parasites of Cattle in Central Java

Hamid

Kristianingrum

Prastowo³

et al. 2016

American Journal of Animal and Veterinary Sciences

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Most of the animals presented monoinfections (79.33%), but concomitant infections were also observed (2 different parasites: 17.67%; 3 different parasites: 2.33%; more than 3 different parasites: 0.67%). With this work we proved the high level of parasitism in cattle of Central Java and we intensively highlight the need to find adequate control measures against parasitic diseases in order to reduce the detrimental impact of parasitosis in cattle.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal Parasites of Cattle in Central Java

Hamid

Kristianingrum

Prastowo³

et al. 2016

American Journal of Animal and Veterinary Sciences

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“…In order to eliminate coccidian infection, a Baycox 5% prepara-tion was used after the second parasitological stool examination. In the authors' experience, Baycox is effective against the intracellular developmental stages of coccidia and is very effective in treating Isospora suis in piglets; thus, it was the treatment of choice here (Mundt et al 2005). Three days after the use of Baycox, a fourth parasitological stool examination was performed.…”

Section: Resultsmentioning

confidence: 99%

Modulation of specific biochemical blood parameters by helminth infection in laboratory Beagle dogs

Szweda¹,

Szarek²,

Babińska³

et al. 2012

Polish Journal of Veterinary Sciences

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The objective of this study was to examine the independent effect of helminths infection on biochemical blood parameters in Beagles intended for laboratory use which may contribute to a change of experimental results. As a result of research, the authors confirmed the negative effect of helminth invasion on the metabolism of the liver and kidney in laboratory dogs. Stool samples from thirty Beagle puppies were examined for parasites before the puppies were moved to the animal facility, and all were dewormed with Vetminth paste on the day they were moved. Stool examination was performed three more times and animals were given Drontal Plus flavor (Bayer) and Baycox 5% (Bayer). A fourth parasitological examination revealed no intestinal parasites in the feces. Three blood biochemical tests were performed. Experimental results clearly indicate the significant impact of intestinal parasites in dogs used in experiments.

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“…In our study, infected calves in all groups had faecal oocyst scores of 3.16 ± 0.739 prior to treatment, which is comparable to the results of Castro-Hermida et al (2001), who reported 3 ± 0.8. In addition to common fluid therapy, we administered toltrazuril that has been used for the treatment of parasitic diseases such as neosporosis and coccidiosis, caused by other apicomplexan parasites (Gottstein et al 2001;Cuteri et al 2005;Epe et al 2005;Mundt et al 2005;Ocal et al 2007). Azithromycin, a macrolide antibiotic used for treatment of toxoplasmosis (Degerli et al 2003), was also tested in this study.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of a combination of azithromycin and toltrazuril for the treatment of calves naturally infected with cryptosporidiosis: a randomised, double-blind, placebo-controlled comparative clinical trial

Yağci¹,

Öcal²,

Duru³

et al. 2017

Vet. Med.

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Cryptosporidium spp. are important emerging pathogens that can cause infections in humans, especially in immunosuppressed patients. Treatment of diseased calves that shed the infectious stage of the protozoon is critically important to prevent contamination by Cryptosporidium spp. oocysts. The objective of this study was to determine if a combination of azithromycin and toltrazuril provides a better treatment option for calf cryptosporidiosis compared to the use of either agent alone. A total of 55 Holstein calves with cryptosporidiosis were randomly assigned into four groups. Group A (n = 15) received azithromycin at a dose of 20 mg/kg/day per os for six days, group T (n = 15) received toltrazuril at a dose of 20 mg/kg per os every other day on a total of three occasions, and group AT (n = 15) received the combination of both drugs. The control group (n = 10) received purified water. A randomised, placebo-controlled, double-blinded clinical study was designed. The number of oocysts in faeces and clinical parameters were followed daily. Selected haematological and biochemical parameters were measured at the beginning and end of the study. The calves receiving the combination of azithromycin and toltrazuril exhibited a better clinical score as well as the lowest number of oocysts at all time-points. In conclusion, the combination of azithromycin and toltrazuril promotes rapid clinical recovery in calves infected with cryptosporidiosis and stops oocyst shedding. Thus, the combination of azithromycin and toltrazuril is an effective alternative treatment option for calf cryptosporidiosis.

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Control of clinical coccidiosis of calves due to Eimeria bovis and Eimeria zuernii with toltrazuril under field conditions

Cited by 58 publications

References 3 publications

Gastrointestinal Parasites of Cattle in Central Java

Gastrointestinal Parasites of Cattle in Central Java

Modulation of specific biochemical blood parameters by helminth infection in laboratory Beagle dogs

The efficacy of a combination of azithromycin and toltrazuril for the treatment of calves naturally infected with cryptosporidiosis: a randomised, double-blind, placebo-controlled comparative clinical trial

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