Control of cerebrovascular patterning by neural activity during postnatal development

Lacoste, Baptiste; Gu, Chenghua

doi:10.1016/j.mod.2015.06.003

Cited by 51 publications

(62 citation statements)

References 136 publications

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“…In rodents before post-natal day 11, brain activation is not associated with sustained CBF increases, leading to an absent or negative BOLD signal (Colonnese et al, 2008; Kozberg et al, 2013). The lack of a flow response may be important for vascular development since the resulting hypoxia is a critical stimulus for cerebral angiogenesis (Lacoste and Gu, 2015). However, in the second and third week of life neural activity leads to increasingly larger hemodynamic responses resulting in progressively larger BOLD signals (Colonnese et al, 2008).…”

Section: Neurovascular Couplingmentioning

confidence: 99%

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Iadecola

2017

Neuron

1,646

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The concept of neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke, emphasizes the intimate relationship between the brain and its vessels. Since then, the NVU has attracted the interest of the neuroscience community resulting in considerable advances in the field. Here the current state-of-knowledge of the NVU will be assessed, focusing on one of its most vital roles: the coupling between neural activity and blood flow. The evidence supports a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process involving neuronal-astrocytic signaling to local blood vessels, to a multidimensional one in which mediators released from multiple cells engage distinct signaling pathways and effector systems across the entire cerebrovascular network in a highly orchestrated manner. The recently appreciated NVU dysfunction in neurodegenerative diseases, although still poorly understood, supports emerging concepts that maintaining neurovascular health promotes brain health.

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Section: Neurovascular Couplingmentioning

confidence: 99%

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Iadecola

2017

Neuron

1,646

1,649

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“…Harb et al demonstrated that young adult mice (<3 months old) placed in hypoxia form significantly more vessels, and that these vessels are not eliminated once the animal is brought back to normoxic conditions (Harb et al, 2013). Hypoxia induces increases in vessel growth through the activation of hypoxia-inducible transcription factors (known as HIFs; see chapter “Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina” by T. Kurihara for details), which in turn upregulate expression of signaling molecules involved in angiogenesis such as VEGF (Lacoste and Gu, 2015; Rey and Semenza, 2010). …”

Section: The Newborn Brain’s Unique Metabolic Environmentmentioning

confidence: 99%

“…The relative hypoxias that occur in response to neural activity in the absence of high-amplitude neurovascular coupling described earlier could be necessary to drive postnatal angiogenesis (Lacoste and Gu, 2015). …”

Section: The Newborn Brain’s Unique Metabolic Environmentmentioning

confidence: 99%

Neurovascular coupling and energy metabolism in the developing brain

Kozberg

Hillman

2016

Progress in Brain Research

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In the adult brain, increases in local neural activity are almost always accompanied by increases in local blood flow. However, many functional imaging studies of the newborn and developing human brain have observed patterns of hemodynamic responses that differ from adult responses. Among the proposed mechanisms for the observed variations is that neurovascular coupling itself is still developing in the perinatal brain. Many of the components thought to be involved in actuating and propagating this hemodynamic response are known to still be developing postnatally, including perivascular cells such as astrocytes and pericytes. Both neural and vascular networks expand and are then selectively pruned over the first year of human life. Additionally, the metabolic demands of the newborn brain are still evolving. These changes are highly likely to affect early postnatal neurovascular coupling, and thus may affect functional imaging signals in this age group. This chapter will discuss the literature relating to neurovascular development. Potential effects of normal and aberrant development of neurovascular coupling on the newborn brain will also be explored, as well as ways to effectively utilize imaging techniques that rely on hemodynamic modulation such as fMRI and NIRS in younger populations.

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“…; Kozberg & Hillman, ). This early inverted vascular response is thought to be an important factor in the development of a healthy, mature cerebrovascular architecture and perhaps also the blood–brain barrier (reviewed in Lacoste & Gu, ).…”

Section: Introductionmentioning

confidence: 99%

Binaural blood flow control by astrocytes: listening to synapses and the vasculature

Mishra

2016

The Journal of Physiology

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Astrocytes are the most common glial cells in the brain with fine processes and endfeet that intimately contact both neuronal synapses and the cerebral vasculature. They play an important role in mediating neurovascular coupling (NVC) via several astrocytic Ca -dependent signalling pathways such as K release through B channels, and the production and release of arachidonic acid metabolites. They are also involved in maintaining the resting tone of the cerebral vessels by releasing ATP and COX-1 derivatives. Evidence also supports a role for astrocytes in maintaining blood pressure-dependent change in cerebrovascular tone, and perhaps also in blood vessel-to-neuron signalling as posited by the 'hemo-neural hypothesis'. Thus, astrocytes are emerging as new stars in preserving the intricate balance between the high energy demand of active neurons and the supply of oxygen and nutrients from the blood by maintaining both resting blood flow and activity-evoked changes therein. Following neuropathology, astrocytes become reactive and many of their key signalling mechanisms are altered, including those involved in NVC. Furthermore, as they can respond to changes in vascular pressure, cardiovascular diseases might exert previously unknown effects on the central nervous system by altering astrocyte function. This review discusses the role of astrocytes in neurovascular signalling in both physiology and pathology, and the impact of these findings on understanding BOLD-fMRI signals.

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Control of cerebrovascular patterning by neural activity during postnatal development

Cited by 51 publications

References 136 publications

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Neurovascular coupling and energy metabolism in the developing brain

Binaural blood flow control by astrocytes: listening to synapses and the vasculature

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