Control of Blood Pressure and Other Cardiovascular Risk Factors at Different Practice Settings: Outcomes of Care Provided to Diabetic Women Compared to Men

McFarlane, Samy I.; Castro, Jonathan Pena; Kaur, Jasjeet; Shin, John; Kelling, Douglas; Farag, Amal; Simon, Nicole; El‐Atat, Fadi; Sacerdote, Alan; Basta, Emad; Flack, John M.; Bakris, George L.; Sowers, James R.

doi:10.1111/j.1524-6175.2005.03869.x

Cited by 49 publications

(26 citation statements)

References 41 publications

(44 reference statements)

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“…These data are consistent with two studies by our group involving various ethnic populations and demonstrating a high prevalence of obesity and dismal control of CVD risk factors among diabetes patients [5,6]. In our studies, less than 5% of diabetes patients achieved blood pressure, glycemic, and lipid control simultaneously [5,6].…”

Section: Introductionsupporting

confidence: 95%

Antidiabetic medications and weight gain: Implications for the practicing physician

McFarlane

2009

Curr Diab Rep

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Obesity is a major risk factor for diabetes and cardiovascular disease, and most people with diabetes are overweight or obese. Weight reduction has been shown to improve glycemic control and reduce cardiovascular risk in the diabetic population. While physicians strive to achieve better glycemic control for their patients with diabetes, they are faced with the problem of weight gain that is commonly encountered with the use of antidiabetic agents, particularly insulin, insulin secretagogues, and thiazolidinediones. Weight gain in this population could offset the beneficial effects of good glycemic control and discourage patients from adhering to treatment. In this review, we discuss the effects of the various antidiabetic agents on body weight, highlighting the potential mechanisms and the implications of weight gain in this population. We also present the available therapeutic modalities that have the potential of achieving better glycemic control without adverse effects on body weight.

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Section: Introductionsupporting

confidence: 95%

Antidiabetic medications and weight gain: Implications for the practicing physician

McFarlane

2009

Curr Diab Rep

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“…Previous studies have reported similar low percentage of patients achieving the combined ADA goals. 11,12 In the present study, optimal glycemic control was achieved by only one-third (34.4%) of the study population. Rest two-thirds of the patients had suboptimal control, out of which more than half were having very poor control with HbA1c of >9%.…”

Section: Discussionmentioning

confidence: 91%

“…10 The combined control of all the three target levels was achieved by even lesser percentage of patients. 11,12 Most studies that assessed the glycemic control of the subjects with diabetes did not look into the status of optimal control of comorbidities including dyslipidemia. 10 Moreover, the factors associated with DR in the group with suboptimal metabolic control have not been evaluated in population-based studies.…”

mentioning

confidence: 99%

Prevalence and Risk Factors of Diabetic Retinopathy in Subjects with Suboptimal Glycemic, Blood Pressure and Lipid Control. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS, Report 33)

Raman

Gupta

Kulothungan

et al. 2012

Current Eye Research

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“…Step 5: Measure Arterial Blood Pressure A large percentage of human type 2 diabetics are hypertensive, therefore control of blood pressure is essential to retard or prevent complications such as renal failure, retinopathy, or accelerated atherosclerosis (Bell et al 2005;Buch et al 2005;Cueto-Manzano et al 2005;McFarlane et al 2005;Teitelbaum et al 2005). Validated noninvasive methods for measuring blood pressure are available in several species (Krege et al 1995;Mesangeau et al 2000;Springett et al 2001).…”

Section: Criteria For Validating Models Of Type 2 Insulin-resistant Dmentioning

confidence: 98%

Swine Models of Type 2 Diabetes Mellitus: Insulin Resistance, Glucose Tolerance, and Cardiovascular Complications

Bellinger¹,

Merricks²,

Nichols³

2006

ILAR Journal

147

110

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In humans, diabetes mellitus (DM) is considered a heterogeneous metabolic disorder. Swine have been used as a model for many human conditions including type 1 (insulindeficient) and type 2 (insulin-resistant) DM research because of their phenotypic similarities to humans including: cardiovascular anatomy and function, metabolism, lipoprotein profile, size, tendency to obesity, and omnivorous habits. There is phenotypic overlap between the two types of DM and pig models show characteristics and complications of both. Streptozotocin and alloxan have been used to create insulin deficient diabetes in pigs. One of the most unique and useful phenotypes is that these insulin-deficient pigs develop more severe coronary atherosclerosis than nondiabetic controls. It is not fully understood why patients with either type 1 or type 2 DM have increased severity and diffuseness of atherosclerosis compared with nondiabetic patients. The current human epidemic of type 2 DM and its attendant cardiovascular complications underscore the unmet need for creating a useful, readily available animal model of type 2 insulin resistant DM that also develops coronary artery atherosclerosis. The phenotypic susceptibility to coronary atherosclerosis makes pigs an attractive species to identify causative mechanisms. Suggested criteria for validation of an animal model of humanoid type 2 DM are described. The goal would be to develop a useful animal model for mechanistic studies as well as to develop and test novel therapeutics both for type 2 DM as well as its cardiovascular complications.

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Control of Blood Pressure and Other Cardiovascular Risk Factors at Different Practice Settings: Outcomes of Care Provided to Diabetic Women Compared to Men

Cited by 49 publications

References 41 publications

Antidiabetic medications and weight gain: Implications for the practicing physician

Antidiabetic medications and weight gain: Implications for the practicing physician

Prevalence and Risk Factors of Diabetic Retinopathy in Subjects with Suboptimal Glycemic, Blood Pressure and Lipid Control. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS, Report 33)

Swine Models of Type 2 Diabetes Mellitus: Insulin Resistance, Glucose Tolerance, and Cardiovascular Complications

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