Control of Biofilm at the Tooth‐Restoration Bonding Interface: A Question for Antibacterial Monomers? A Critical Review

Melo, Mary Anne S.; Weir, Michael D.; Li, Fang; Cheng, Lei; Zhang, Ke; Xu, Hockin H.K.

doi:10.1002/9781119526445.ch8

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…In the presence of advanced demineralization that is associated with cavities formation, esthetic tooth-colored restorative materials are the chosen materials due to improved esthetic properties and more conservative preparation techniques. Clinical restorative polymer materials are represented by a set of materials including direct resin composite restorative, enamel-dentin adhesives and dental primers (adhesion promoters) with similar primary chemical composition [ 10 ]. These materials have been used as direct restorative materials to replace missing biological tissue for more than 40 years and do not exert any detrimental effect on caries-related pathogens or positive impact in the mineral balance of hard tissues.…”

Section: Introductionmentioning

confidence: 99%

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Balhaddad

Kansara

Hidan

et al. 2019

Bioactive Materials

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111

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Millions of people worldwide suffer from a toothache due to tooth cavity, and often permanent tooth loss. Dental caries, also known as tooth decay, is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings (tooth colored fillings). Until now, restorative polymeric fillings present no bioactivity. The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials. Nanotechnology has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria. Nano-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative materials. The bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against carries-related pathogens. It has been suggested that this bioactivity could minimize the incidence of caries around restorations (CARS) and increase the longevity of such filling materials. The last few years witnessed growing numbers of studies on the preparation evaluations of these novel materials. Herein, the caries disease process and the role of pathogenic caries-related biofilm, the increasing incidence of CARS, and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are discussed. We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.

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Section: Introductionmentioning

confidence: 99%

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Balhaddad

Kansara

Hidan

et al. 2019

Bioactive Materials

Self Cite

120

111

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“…Bonding agents (dental adhesives) are used to bond resin composite restorations to the tooth structure [ 97 ]. These adhesive resins penetrate etched dentin, infiltrate the exposed collagen, and form a hybrid layer between the tooth structure and resin-based materials allowing the material to adhere firmly without dislodgment or loss of retention [ 98 ].…”

Section: Contact-killing Materials As a Strategy In Resin-based Rementioning

confidence: 99%

Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials

et al. 2020

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Polymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored fillings, sealing root canal systems, and many other dental restorative applications. However, polymeric materials are highly susceptible to bacterial attachment and colonization, leading to dental diseases. Many approaches have been investigated to minimize the formation of biofilms over polymeric restorative materials and at the tooth/material interfaces. Among them, contact-killing compounds have shown promising results to inhibit dental biofilms. Contact-killing compounds can be immobilized within the polymer structure, delivering a long-lasting effect with no leaching or release, thus providing advantages compared to release-based materials. This review discusses cutting-edge research on the development of contact-killing compounds in dental restorative materials to target oral pathogens. Contact-killing compounds in resin composite restorations, dental adhesives, root canal sealers, denture-based materials, and crown cements have all demonstrated promising antibacterial properties. Contact-killing restorative materials have been found to effectively inhibit the growth and activities of several oral pathogens related to dental caries, periodontal diseases, endodontic, and fungal infections. Further laboratory optimization and clinical trials using translational models are needed to confirm the clinical applicability of this new generation of contact-killing dental restorative materials.

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“…Dental monomers such as bisphenol A-glycidyl dimethacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGMA) may alter the metabolism and promote the proliferation of Streptococcus mutans [ 14 ]. Therefore, the synthesis of free radical monomers that have quaternary ammonium groups in their chemical structures paved the way for a noninvasive, biofilm-targeted method that can be used against oral biofilms [ 15 ]. Reactive and easily miscible quaternary ammonium monomers have the advantage of copolymerizing with the current dental resin systems through covalent bonding with the polymer network.…”

Section: Introductionmentioning

confidence: 99%

Human In Situ Study of the effect of Bis(2-Methacryloyloxyethyl) Dimethylammonium Bromide Immobilized in Dental Composite on Controlling Mature Cariogenic Biofilm

Melo

Weir

Passos

et al. 2018

IJMS

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Cariogenic oral biofilms cause recurrent dental caries around composite restorations, resulting in unprosperous oral health and expensive restorative treatment. Quaternary ammonium monomers that can be copolymerized with dental resin systems have been explored for the modulation of dental plaque biofilm growth over dental composite surfaces. Here, for the first time, we investigated the effect of bis(2-methacryloyloxyethyl) dimethylammonium bromide (QADM) on human overlying mature oral biofilms grown intra-orally in human participants for 7–14 days. Seventeen volunteers wore palatal devices containing composite specimens containing 10% by mass of QADM or a control composite without QADM. After 7 and 14 days, the adherent biofilms were collected to determine bacterial counts via colony-forming unit (CFU) counts. Biofilm viability, chronological changes, and percentage coverage were also determined through live/dead staining. QADM composites caused a significant inhibition of Streptococcus mutans biofilm formation for up to seven days. No difference in the CFU values were found for the 14-day period. Our findings suggest that: (1) QADM composites were successful in inhibiting 1–3-day biofilms in the oral environment in vivo; (2) QADM significantly reduced the portion of the S. mutans group; and (3) stronger antibiofilm activity is required for the control of mature long-term cariogenic biofilms. Contact-killing strategies using dental materials aimed at preventing or at least reducing high numbers of cariogenic bacteria seem to be a promising approach in patients at high risk of the recurrence of dental caries around composites.

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Control of Biofilm at the Tooth‐Restoration Bonding Interface: A Question for Antibacterial Monomers? A Critical Review

Cited by 4 publications

References 67 publications

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials

Human In Situ Study of the effect of Bis(2-Methacryloyloxyethyl) Dimethylammonium Bromide Immobilized in Dental Composite on Controlling Mature Cariogenic Biofilm

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