Control of bacterial and fungal biofilms by natural products of Ziziphus joazeiro Mart. (Rhamnaceae)

Andrade, Jacqueline Cosmo; Silva, Ana Raquel Pereira da; Freitas, Maria Audilene de; Ramos, Bárbara de Azevedo; Freitas, Thiago Sampaio de; Santos, Franz de Assis Graciano dos; Leite-Andrade, Melyna Chaves; Nunes, Michellângelo; Tintino, Saulo Relison; Silva, Márcia Vanusa da; Correia, Maria Tereza dos Santos; Lima-Neto, Reginaldo Gonçalves de; Neves, Rejane Pereira; Coutinho, Henrique Douglas Melo

doi:10.1016/j.cimid.2019.06.006

Cited by 15 publications

(5 citation statements)

References 32 publications

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“…In phytochemical screening studies, S. joazeiro extract exhibited classes of secondary metabolites, such as flavonoids, saponins and tannins, which are associated with different biological activities [12]. Previous studies performed UPLC-ESI-QTOF-MS analysis and showed the presence of rutin (2), kaempferol (3), isorhamnetin (4, 5 and 7), quercetin (6) and saponin derivatives (8, 9, 10 and 11), corroborating this study [16], [23].…”

Section: Discussionsupporting

confidence: 85%

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

Costa,

De Carvalho,

Pereira da Silva

et al. 2024

Preprint

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Anxiety is a multifactorial pathology associated with oxidative stress and changes in different neurotransmitters in the central nervous system (CNS). Sarcomphalus joazeiro (Rhamnaceae) has a predicted effect on the CNS, being considered an alternative for pre-clinical investigations of anxiolytic drugs. The objective of this study is to evaluate the chemical composition, analyze the antioxidant capacity and the anxiolytic effect of the ethanolic extract of S. joazeiro leaves (EEFSJ) in zebrafish. The chemical profile was analyzed by liquid chromatography coupled to mass spectrometry (UPLC-PDA-ESI-QDA). Antioxidant action by DPPH• elimination and ABTS•⁺ capture assays. The 96 h acute toxicity and open field and light and dark tests, for sedative and anxiolytic evaluation, respectively, were applied in vivo, using zebrafish. It was possible to identify 11 compounds from the flavonoid and saponin class. EEFSJ exhibited a mean inhibitory concentration (IC50) of 185.2 ± 2.2 µg/mL and 74.17 ± 1.5 µg/mL against the DPPH• and ABTS•⁺ radicals, respectively. In vivo, EEFSJ demonstrated reduced locomotor activity and an anxiolytic effect similar to diazepam via GABAergic systems, without presenting toxicity within 96 h. These results suggest the safety of using EEFSJ for the development of clinical trials for the production of new anxiolytic drugs.

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Section: Discussionsupporting

confidence: 85%

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

Costa,

De Carvalho,

Pereira da Silva

et al. 2024

Preprint

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“…This could be due to the fact that, as the polymer concentration increased, the film thickness also increased. As a result, the time taken for the disintegration of the film increased, and this was in harmony with Raza et al; Esim et al [40,41]. 3.…”

Section: Influence Of Formulation Variables On Dtsupporting

confidence: 86%

Bi-Laminated Oral Disintegrating Film for Dual Delivery of Pitavastatin Calcium and Lornoxicam: Fabrication, Characterization and Pharmacokinetic Study

et al. 2022

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Objective: Pitavastatin calcium (PT) is an innovative drug of statins that enhances HDL-C and lowers LDL-C. However, myalgia has been reported in hyperlipidemic patients receiving statins. Therefore, co-administration of statins with NSAIDs such as Lornoxicam (LN) could be a solution to the former problem. Accordingly, this study aimed to formulate a bi-laminated oral disintegrating film (ODF) comprising PT in one layer and LN in the second one. Methods: For the formulation and optimization of PT-ODFs, a 31.21 full factorial design was carried out, where the impact of polymer type and concentration on disintegration time (DT) and % PT released after 10 min (Q10) was studied. PT-ODFs were prepared via the solvent casting method and then evaluated. One PT-ODF was chosen to represent the optimum formula according to the criteria of scoring the fastest DT and the highest Q10. The optimized PT-ODF was merged with the second film layer containing LN, forming a bi-laminated ODF named S1 that underwent an in vivo pharmacokinetic study compared to the commercially available tablets for PT (Lipidalon®) and LN (Lornoxicam®) using rats as an animal model. LC-MS/MS was used to analyze plasma drug concentrations. Results: All PT-ODFs showed acceptable outcomes. F1 scored the fastest DT (18.6±1.5 s) and the highest Q10 (91.3±3.0 %). S1 successfully recorded a maximum plasma concentration (Cmax) of 2.04 and 2.24 folds increase for PT and LN, correspondingly, compared to commercially available tablets. Conclusion: Merging PT and LN into bi-laminated ODF was promising for the fast delivery of both drugs with enhanced bioavailability.

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“…Basic order for antifungal effectivity of different groups of EO components is phenol > alcohol > aldehyde > ketone > ester > hydrocarbon. Andrade et al (2019) reported the better antifungal effectiveness of phenolic constituents due to the disintegration of membrane permeability. Ascaridole, a bicyclic monoterpene having a peroxide functional group isolated from Chenopodium ambrosoides EO, was found effective against postharvest pathogen Botrytis cineria due to destruction of the plasma membrane and inhibition of conidial germination (Pizzolitto et al, 2020).…”

Section: Effect On Dna and Gene Expressionmentioning

confidence: 99%

Essential Oils and Their Application in Food Safety

Maurya

Prasad

Das

et al. 2021

Front. Sustain. Food Syst.

144

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Food industries are facing a great challenge due to contamination of food products with different microbes such as bacteria, fungi, viruses, parasites, etc. These microbes deteriorate food items by producing different toxins during pre- and postharvest processing. Mycotoxins are one of the most potent and well-studied toxic food contaminants of fungal origin, causing a severe health hazard to humans. The application of synthetic chemicals as food preservatives poses a real scourge in the present scenario due to their bio-incompatibility, non-biodegradability, and environmental non-sustainability. Therefore, plant-based antimicrobials, including essential oils, have developed cumulative interest as a potential alternative to synthetic preservatives because of their ecofriendly nature and generally recognized as safe status. However, the practical utilization of essential oils as an efficient antimicrobial in the food industry is challenging due to their volatile nature, less solubility, and high instability. The recent application of different delivery strategies viz. nanoencapsulation, active packaging, and polymer-based coating effectively addressed these challenges and improved the bioefficacy and controlled release of essential oils. This article provides an overview of essential oils for the preservation of stored foods against bacteria, fungi, and mycotoxins, along with the specialized mechanism of action and technological advancement by using different delivery systems for their effective application in food and agricultural industries smart green preservative.

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Control of bacterial and fungal biofilms by natural products of Ziziphus joazeiro Mart. (Rhamnaceae)

Cited by 15 publications

References 32 publications

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

Bi-Laminated Oral Disintegrating Film for Dual Delivery of Pitavastatin Calcium and Lornoxicam: Fabrication, Characterization and Pharmacokinetic Study

Essential Oils and Their Application in Food Safety

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