Control of a two-stage mixed suspension mixed product removal crystallizer

Simultaneous design and control of an industrial two-stage mixed suspension mixed product removal crystallizer

“…We consider the cooling crystallization of paracetamol from an aqueous isopropanol mixture [21,48]. Physical properties and kinetic parameters are listed in Table 1.…”

“…Moreover, we want to control the d 43 and the yield Y at their desired setpoints by manipulating the crystallization temperatures (T 1 and T 2 respectively). These input-output pairs have been selected based on previous studies [48,52]. At this early design stage, controllability considerations and saturation of the manipulated variables load are included as nonlinear constraints.…”

“…We include constraints to exclude the saturation of manipulated variables and to guarantee process flexibility to reject the disturbances. Various control designs, some of which have been already presented in [48], have been considered depending on the availability of the monitoring equipment (PAT). The dynamic performance of the optimal configuration are then assessed by closed loop simulation.…”

The Role of Residence Time Distribution in the Continuous Steady-State Mixed Suspension Mixed Product Removal Crystallization of Glycine

“…The control of the full CSD is not possible in practice; however, some of its attributes such as mean size, span, coefficient of variation, and fines fraction can be controlled. 18 A typically large and narrowly distributed crystal product is usually desired from a crystallization process to aid downstream processability. 19 The conventional PFC aims to provide a uniform environment for consistent particles by providing a narrow RTD.…”

“…Therefore, RTD can affect drug substance CQAs such as the crystal size distribution (CSD), which determines filterability, drying times, and final drug product performance. The control of the full CSD is not possible in practice; however, some of its attributes such as mean size, span, coefficient of variation, and fines fraction can be controlled . A typically large and narrowly distributed crystal product is usually desired from a crystallization process to aid downstream processability .…”