Control Mechanisms for Trauma Induced DLSH Reaction (Decrease in Mouse Liver Non-Protein Sulfhydryl).

Effects of trauma on incorporation of l-[35S]cysteine into tissue glutathione

“…The data of Table 1 indicate that decreases in tissue non-protein-SH compounds were induced by trauma in all of the tissues examined, but most markedly in liver and kidney. Differences in liver non-protein-SH compounds between control and traumatized groups of mice were very similar to those found in earlier work (Beck & Linkenheimer, 1952;Beck & Rieck, 1958). In the earlier work, in which liver non-protein-SH was estimated for each mouse used, P values for control versus traumatized groups of mice were almost invariably less than 0-001; hence present differences are considered significant.…”

“…(Received 3 AuguBt 1960) When mice, rats or rabbits are subjected to certain procedures which produce stress or injury, there is a fall in the concentration of non-proteinsulphydryl-group compounds of the liver and other tissues (Stolfi, 1936;Beck & Linkenheimer, 1952;Lindan & Work, 1953;Bartlett & Register, 1953;Beck & Rieck, 1958). The literature suggests that such decrease may be due mainly to decreased synthesis of glutathione, the most abundant component of liver non-protein-sulphydryl-group compounds.…”