“Control” laboratory rodents are metabolically morbid: Why it matters

Martin, Bronwen; Ji, Sunggoan; Maudsley, Stuart; Mattson, Mark P.

doi:10.1073/pnas.0912955107

Cited by 308 publications

(247 citation statements)

References 104 publications

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“…In rodents, daily food intake reduction of 20-40 % significantly reduces WAT (Blüher et al 2003), the risk to develop CVD, or other age-associated diseases (Martin et al 2010) and extends life span by up to 40 % (Barzilai et al 1998). Equivalent findings were observed in humans considering that 1 year of low-energy diet reduces markedly atherosclerosis risk factors such as high body mass index, blood pressure, blood levels of glucose, insulin, CRP, TG, and LDL-c, and increases the levels of HDL-c (Fontana et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Tomada

Fernandes

Guimarães

et al. 2012

AGE

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High-fat (HF) diet regular intake along life highly contributes to vascular dysfunction and to an increment in prevalence of metabolic syndrome (MetS) and erectile dysfunction (ED), a surrogate symptom of occult vascular disease, in the elderly. However, little is known about the effects of energy restriction (ER) alone/or after an HF-feeding period. We show here that in male Sprague-Dawley rats, 16 months of HF-diet consumption led to an increase in body adiposity, blood pressure, lipidemia, C-reactive protein, and insulin resistance and to hypoadiponectinemia, conditions that cluster in MetS. In addition, this treatment strongly favored collagen deposition in cavernous tissue and myocardium. Conversely, for the same time period, the ingestion of 75 % of ad libitum energy intake by controls (ER) extensively counteracted these outcomes. The impact of 6-month ER after 10-month HF period was also analyzed, and despite the decrease in body weight, adiposity, blood pressure, lipidemia, and Creactive protein and improvement of insulin sensitivity, no differences were observed either in adiponectin blood levels or in retroperitoneal fat pad mass. Moreover, this treatment led to a reduction in cavernous tissue collagen deposition, but not in the myocardium, and evidenced differential mobilization of adipose tissue accretions. The data show the ability of HF diet to cause MetS and produce unwanted effects on myocardium and corpora vascular structure. They also indicate that these consequences are preventable upon ER diet starting early, but not later, in life.

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Section: Discussionmentioning

confidence: 99%

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Tomada

Fernandes

Guimarães

et al. 2012

AGE

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“…It is possible that the association between increased risk of developing AD and excess body weight reflects the potential effect of a diet high in simple sugars and fats to the development of AD. A recent study showed reducing caloric intake increases healthspan, reduces damage in the brain due to aging, and provides greater maintenance of various brain functions (Martin et al, 2008; Martin, Golden, Egan, Mattson, & Maudsley, 2007; Martin, Ji, Maudsley, & Mattson, 2010; Martin, Mattson, & Maudsley, 2006). …”

Section: Lifestyle Associations and Interventions For Aging And Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.

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“…However, Martin et al [20] have voiced strong concerns that 'control' mice are in fact 'sedentary, obese and glucose intolerant' and cautioned that this has great potential to 'confound data interpretation on outcomes of human studies.' The authors note that lack of exercise and unlimited access to food are major culprits.…”

Section: Glossarymentioning

confidence: 99%