Control-fluidic CoDesign for paper-based digital microfluidic biochips

Wang, Qin; Li, Zeyan; Cheong, Haena; Kwon, Oh‐Sun; Yao, Hailong; Ho, Tsung-Yi; Shin, Kwanwoo; Li, Bing; Schlichtmann, Ulf; Cai, Yici

doi:10.1145/2966986.2967018

Cited by 23 publications

(5 citation statements)

References 22 publications

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“…To resolve this issue, researchers proposed control-fluidic codesign methodologies, which simultaneously adjusted the control line routing and the arrangement of the fluid droplets. The proposed method successfully eliminated the interferences during operation of the p-DMF device and achieved an optimal solution [ 143 , 144 ]. The improved droplet and electrode-oriented flows might increase the potential for p-DMF devices to be used as electrochemical detectors.…”

Section: Detection Techniquesmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.

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Section: Detection Techniquesmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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“…Without a feedback system, a droplet can exhibit unexpected movement when an automatic control system is used. To solve this problem, researchers proposed better algorithms for eliminating the interferences during the operation of a p-DMF chip [94,95].…”

Section: Droplet Manipulations In P-dmf Devicesmentioning

confidence: 99%

Programmable Paper-Based Microfluidic Devices for Biomarker Detections

et al. 2019

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Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.

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Section: Droplet Manipulations In P-dmf Devicesmentioning

confidence: 99%

Micro- and Nanofluidics for Bionanoparticle Analysis

Zeng¹,

Cheng²

2019

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of Surgery at Massachusetts General Hospital. The focus of her research is to develop microfluidic devices for cell and pathogen analysis. In combination with nanomaterials and biosensors, these microfluidic devices are expected to perform automated sample processing and sensitive analyte detection towards point-of-care uses. She has published more than 60 referred technical papers, has been granted several U.S. patents and has obtained research funding from NIH, NSF, and DoD.Yong Zeng currently is a Docking Scholar Associate Professor in the

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Control-fluidic CoDesign for paper-based digital microfluidic biochips

Cited by 23 publications

References 22 publications

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Programmable Paper-Based Microfluidic Devices for Biomarker Detections

Micro- and Nanofluidics for Bionanoparticle Analysis

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