Control by Viability in a Chemotherapy Cancer Model

Serhani, Mustapha; Essaadi, H; Kassara, Khalid; Boutoulout, Ali

doi:10.1007/s10441-019-09344-0

Cited by 5 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this work, we adapt the set-valued analysis methods developed in the previous works [11][12][13][14][15][16][17][18], to approach a model of combined chemotherapy control in cancer, and make the solution viable on decreasing subset, with converging tumor density towards zero [11]. Investigates a general class of immunotherapy ODE models and gives some numerical examples [12]. Evokes viability and set-valued theories to provide chemotherapy protocol laws [13].…”

Section: Introductionmentioning

confidence: 99%

Set-Valued Control of Cancer by Combination Chemotherapy

MOUSTAFİD¹

2023

Journal of Mathematical Sciences and Modelling

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Set-Valued Control of Cancer by Combination Chemotherapy

MOUSTAFİD¹

2023

Journal of Mathematical Sciences and Modelling

View full text Add to dashboard Cite

show abstract

“…Cancer is one of the significant causes of global mortality and morbidity and remains a compelling challenge for public health ( 1 , 2 ). For instance, prostate cancer is the most common cancer in men after lung cancer ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells

et al. 2022

View full text Add to dashboard Cite

The use of functional foods’ phytochemicals in the chemoprevention of different cancer diseases has become one of the hot scientific areas in the clinical nutrition field. For instance, the Khalas palm cultivar (KPC; Phoenix dactylifera) is one of the natural sustainable resources that have high bioactivity and functionality. This study aimed to investigate the antiproliferative activity and mode of action of KPC’s different parts on prostate (Pc3) and pancreatic (panc1) cancer cells at a molecular level. In the methods, KPC’s leaves, seeds, and fruits’ chemical composition and phytochemical analysis were analyzed. Also, the cytotoxic effects of each extract were assessed against pc3 and panc1 cell lines. Besides, induction of apoptosis, cell cycle analysis, and gene expression of both Cap3 and Cap9 were studied. The obtained results indicated that KPC leaves extract exhibited the highest significant (P < 0.01) anti-proliferation activity against the utilized cancer cell lines compared to fruits and seeds extracts. Also, there were significant (P < 0.05) differences in the phenolic contents, flavonoid of compounds, and antioxidant power of the leaves when compared to the seeds and fruits. Additionally, the highest cytotoxic effect (lowest IC50) was recorded with leave extract than seeds and fruits. Meanwhile, the seeds extract induced (P < 0.05) the apoptosis and arrested cells in the G2/M phase as well as up-regulated the gene expression of the apoptotic-related genes (Casp3 and Casp9) compared to the control group. In conclusion, this study showed that the presence of bioactive components in the KPC different parts extracts have the significant ability to induce the apoptotic pathway that could down-regulate the proliferation of prostate (pc3) and pancreatic (panc1) cancer cells. The pathway mechanism of action was induced by the phytol molecule presented in its leaves extract.

show abstract

“…Mathematical modeling of biological phenomena has a long history, where several studies have been established. Notably, cancer and its evolution, which has a great interest of mathematical researchers [3,7,10,15,17,19,20], in the purpose of understanding the dynamics of tumor cells and their interaction with other types of cells, and by analyzing mathematical models to obtain results that can help medical staff to take a decision. For example, Depillis et.…”

Section: Introductionmentioning

confidence: 99%

Multiobjective approach in the treatment of cancer

Sabir

Raïssi

Serhani

2021

Math. Model. Nat. Phenom.

View full text Add to dashboard Cite

In this work we deal with a cancer problem involving the growth of tumor cells and their interaction with effector cells. The goal is to find an optimal control minimizing tumor cells density together with the amount of chemotherapy drugs and maximizing the density of effector cells. By invoking the multi-objective optimization we characterize optimal Pareto solutions and give simulation of Pareto front.

show abstract

Control by Viability in a Chemotherapy Cancer Model

Cited by 5 publications

References 16 publications

Set-Valued Control of Cancer by Combination Chemotherapy

Set-Valued Control of Cancer by Combination Chemotherapy

Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells

Multiobjective approach in the treatment of cancer

Contact Info

Product

Resources

About