Control and gating of kinesin-microtubule motility on electrically heated thermo-chips

Ramsey, Laurence; Schroeder, Viktor; Zalinge, Harm van; Berndt, Michael; Korten, Till; Diez, Stefan; Nicolau, Dan V.

doi:10.1007/s10544-014-9848-2

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…Motility positive relationship with cyclin, kinesin has been reported in references as follows: Over-expression of cyclin D1 induces glioma invasion by increasing matrix metalloproteinase activity and cell motility; Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility; Cyclin D1 governs adhesion and motility of macrophages; The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility; Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells 40 - 44 . Kinesin-dependent motility generation as target mechanism of cadmium intoxication; Effects of alpha-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system; TRIM3 regulates the motility of the kinesin motor protein KIF21B; Control and gating of kinesin-microtubule motility on electrically heated thermo-chips 45 - 48 .…”

Section: Discussionmentioning

confidence: 99%

High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C

Zhou¹,

Wang²,

Huang³

et al. 2015

J. Cancer

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48 different Pearson mutual-positive-correlation epidermal growth factor receptor (EGFR_1)-activatory molecular feedback, up- and down-stream network was constructed from 171 overlapping of 366 GRNInfer and 223 Pearson under EGFR_1 CC ≥0.25 in high lung adenocarcinoma compared with low human normal adjacent tissues. Our identified EGFR_1 inside-out upstream activated molecular network showed SLC2A1 (solute carrier family 2 (facilitated glucose transporter) member 1), CCNB2 (cyclin B2), HMMR (hyaluronan-mediated motility receptor (RHAMM)), KIF11 (kinesin family member 11), NUSAP1 (nucleolar and spindle associated protein 1), PRC1 (protein regulator of cytokinesis 1), UBE2C (ubiquitin-conjugating enzyme E2C) in high lung adenocarcinoma. EGFR_1 inside-out upstream activated terms network includes intracellular, membrane fraction, cytoplasm, plasma membrane, integral to membrane, basolateral plasma membrane, transmembrane transport, nucleus, cytosol, cell surface; T cell homeostasis, inflammation; microtubule cytoskeleton, embryonic development (sensu Mammalia), cell cycle, mitosis, thymus development, cell division, regulation of cell cycle, Contributed--cellular process--Hs cell cycle KEGG, cytokinesis, M phase, M phase of mitotic cell cycle, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, cell motility, locomotion, locomotory behavior, neoplasm metastasis, spindle pole, spindle microtubule, microtubule motor activity, microtubule-based movement, mitotic spindle organization and biogenesis, mitotic centrosome separation, spindle pole body organization and biogenesis, microtubule-based process, microtubule, cytokinesis after mitosis, mitotic chromosome condensation, establishment of mitotic spindle localization, positive regulation of mitosis, mitotic spindle elongation, spindle organization and biogenesis, positive regulation of exit from mitosis, regulation of cell proliferation, positive regulation of cell proliferation based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in high lung adenocarcinoma. Therefore, we propose high EGFR_1 inside-out activated inflammation-induced motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C in lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C

Zhou¹,

Wang²,

Huang³

et al. 2015

J. Cancer

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“…The gliding velocity is governed by the ATP concentration and temperature, , and the direction of the filament movement follows a persistent random walk driven by thermal fluctuations of the tip of the moving filaments . This persistent random walk, as well as the interaction of the filament with obstacles, can be simulated using Brownian dynamics methods. − Gliding filaments can be confined by guiding structures to prescribed paths, ,− directed by obstacles, controlled by light, ,− or other stimuli, ,− and can capture analytes and carry cargo. ,− The natural arrangement of stationary filaments supporting the movement of biomolecular motors is also employed, but the transport distance is largely limited to the length of the filament or filament assembly in this geometry. These discoveries led to more advanced applications including sensors, − computation, screens, and switches .…”

Section: Linear Biomolecular Motors Applicationsmentioning

confidence: 99%

Synthetic Systems Powered by Biological Molecular Motors

2019

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Biological molecular motors (or biomolecular motors for short) are nature’s solution to the efficient conversion of chemical energy to mechanical movement. In biological systems, these fascinating molecules are responsible for movement of molecules, organelles, cells, and whole animals. In engineered systems, these motors can potentially be used to power actuators and engines, shuttle cargo to sensors, and enable new computing paradigms. Here, we review the progress in the past decade in the integration of biomolecular motors into hybrid nanosystems. After briefly introducing the motor proteins kinesin and myosin and their associated cytoskeletal filaments, we review recent work aiming for the integration of these biomolecular motors into actuators, sensors, and computing devices. In some systems, the creation of mechanical work and the processing of information become intertwined at the molecular scale, creating a fascinating type of “active matter”. We discuss efforts to optimize biomolecular motor performance, construct new motors combining artificial and biological components, and contrast biomolecular motors with current artificial molecular motors. A recurrent theme in the work of the past decade was the induction and utilization of collective behavior between motile systems powered by biomolecular motors, and we discuss these advances. The exertion of external control over the motile structures powered by biomolecular motors has remained a topic of many studies describing exciting progress. Finally, we review the current limitations and challenges for the construction of hybrid systems powered by biomolecular motors and try to ascertain if there are theoretical performance limits. Engineering with biomolecular motors has the potential to yield commercially viable devices, but it also sharpens our understanding of the design problems solved by evolution in nature. This increased understanding is valuable for synthetic biology and potentially also for medicine.

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“…The intensity of an electric field can be encoded into amplitudes of the filaments' lateral fluctuations. Nicolau and colleagues demonstrated the organisation of actin filamentous structures in electric fields, both parallel and perpendicular to the field direction [88,156,155]. This will act as memory write operation.…”

Section: Meso-scale Memory Via Re-orientation Of Filaments Bundlesmentioning

confidence: 99%

Towards Cytoskeleton Computers. A Proposal

Adamatzky¹,

Tuszyński²,

Pieper³

et al. 2019

From Parallel to Emergent Computing

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We propose a road-map to experimental implementation of cytoskeleton-based computing devices. An overall concept is described in the following.• Collision-based cytoskeleton computers implement logical gates via interactions between travelling localisation (voltage solitons on AF/MT chains and AF/MT polymerisation wave fronts).• Cytoskeleton networks are grown via programmable polymerisation. Data are fed into the AF/MT computing networks via electrical and optical means.• Data signals are travelling localisations (solitons, conformational defects) at the network terminals.• The computation is implemented via collisions between the localisations at structural gates (branching sites) of the AF/MT network.• The results of the computation are recorded electrically and/or optically at the output terminals of the protein networks.• As additional options, optical I/O elements are envisaged via direct excitation of the protein network and by coupling to fluorescent molecules.

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Control and gating of kinesin-microtubule motility on electrically heated thermo-chips

Cited by 9 publications

References 26 publications

High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C

High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C

Synthetic Systems Powered by Biological Molecular Motors

Towards Cytoskeleton Computers. A Proposal

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