Contributors

Abid, Shariq; Adnot, Serge; Agustí, Àlvar; Beaulieu, Delphine; Bhushan, Anil; Bird, Thomas; Born, Emmanuelle; Bréau, Marielle; Chin, Alexander F.; Elisseeff, Jennifer H.; Erlangga, Zulrahman; Evangelou, Konstantinos; Faner, Rosa; Farr, Joshua N.; Georgakopoulou, Eleni A.; González-Gualda, Estela; Gorgoulis, Vassilis G.; Gray-Gaillard, Elise; Han, Jin Soo; Hernández-González, Fernanda; Houssaïni, Amal; Jensen, Michael D.; Jurk, Diana; Katsuumi, Goro; Khosla, Sundeep; Kiourtis, Christos; Kirkland, James L.; Kovatcheva, Marta; Lipskaia, Larissa; López-Domínguez, José A; Macías, David; Marcos, Élisabeth; Maus, Máté; Melk, Anette; Meyer, Kathleen; Michel, John W.; Minamino, Tetsuo; Miwa, Soichi; Monroe, David G.; Muñoz‐Espín, Daniel; Ou, Hui-Ling; Palmer, Allyson K.; Saito, Nayuta; Schmitt, Roland; Sellarés, Jacobo; Serrano, Manuel; Sung, Myong-Hee; Tchkonia, Tamar; Thompson, Peter J.; Zglinicki, Thomas von; Wan, Tengfei; Zhang, Peisu

doi:10.1016/b978-0-12-822514-1.01002-6

Cited by 1 publication

(1 citation statement)

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“…77 Several studies have inferred that adipose tissue serves as a primary reservoir of senescent cells. 78,79 Cellular senescence can be induced by multiple factors, such as DNA damage, telomere attrition, oxidative damage, mitotic stress, mitochondrial dysfunction, ER stress, and oncogene activation. [80][81][82][83][84][85][86] DNA damage, which is frequently induced by telomere shortening and early onset cellular senescence, is the key factor in triggering senescence among these factors.…”

Section: Senescence In the Microenvironment Of Tnbc Patients With Obe...mentioning

confidence: 99%

Fat Biology in Triple-Negative Breast Cancer: Immune Regulation, Fibrosis, and Senescence

Lee,

Fang

2023

Journal of Obesity & Metabolic Syndrome

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Obesity, now officially recognized as a disease requiring intervention, has emerged as a significant health concern due to its strong association with elevated susceptibility to diverse diseases and various types of cancer, including breast cancer. The link between obesity and cancer is intricate, with obesity exerting a significant impact on cancer recurrence and elevated mortality rates. Among the various subtypes of breast cancer, triple-negative breast cancer (TNBC) is the most aggressive, accounting for 15% to 20% of all cases. TNBC is characterized by low expression of estrogen receptors and progesterone receptors as well as the human epidermal growth factor 2 receptor protein. This subtype poses distinct challenges in terms of treatment response and exhibits strong invasiveness. Furthermore, TNBC has garnered attention because of its association with obesity, in which excess body fat and reduced physical activity have been identified as contributing factors to the increased incidence of this aggressive form of breast cancer. In this comprehensive review, the impact of obesity on TNBC was explored. Specifically, we focused on the three key mechanisms by which obesity affects TNBC development and progression: modification of the immune profile, facilitation of fibrosis, and initiation of senescence. By comprehensively examining these mechanisms, we illuminated the complex interplay between TNBC and obesity, facilitating the development of novel approaches for prevention, early detection, and effective management of this challenging disease.

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