Contributions of water-borne corticosterone as one non-invasive biomarker in assessing nitrate pollution stress in tadpoles of Rana temporaria

Ruthsatz, Katharina; Bartels, Fabian; Mausbach, Jelena

doi:10.1016/j.ygcen.2022.114164

Cited by 6 publications

(2 citation statements)

References 103 publications

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“…Low water level also had no effect on the BCI of individuals, in contrast to the results of our previous study (Kijanović et al, 2023). It is known that a lower BCI correlates with elevated corticosterone levels (e.g., Ruthsatz, Eterovick et al, 2023; Walkowski et al, 2019). Given that desiccation did not affect corticosterone levels, this supports the fact that BCI remained unchanged, except in the H+CORT treatment where BCI was lowest, but only significantly different compared to the H treatment.…”

Section: Discussionmentioning

confidence: 99%

The role of phenotypic plasticity and corticosterone in coping with pond drying conditions in yellow‐bellied toad (Bombina variegata, Linnaeus 1758) tadpoles

Kijanović,

Vukov,

Mirč

et al. 2024

J Exp Zool Pt A

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Amphibian larvae inhabiting temporary ponds often exhibit the capacity to accelerate development and undergo metamorphosis in challenging conditions like desiccation. However, not all species exhibit this ability, the yellow‐bellied toad (Bombina variegata) is one such example. The underlying mechanisms behind the inability to accelerate development under desiccation remain largely unexplored. The hypothalamic–pituitary–interrenal (HPI) axis and corticosterone (CORT), which act synergistically with thyroid hormone, are thought to facilitate metamorphosis in response to desiccation stress. In this study, we aimed to investigate whether modification in the HPI axis, particularly CORT levels, contributes to the absence of adaptive plasticity in B. variegata under desiccation stress. The study design included four treatments: high water level, high water level with exogenous CORT, low water level, and low water level with metyrapone (a CORT synthesis inhibitor). The main objective was to evaluate the effects of these treatments on whole‐body corticosterone levels, life history, morphological traits, and oxidative stress parameters during the prometamorphic and metamorphic climax developmental stages. While low water level had no effect on total corticosterone levels, larval period, body condition index, and metamorphic body shape, it negatively affected metamorph size, mass, and growth rate. Our findings suggest that constant exposure to desiccation stress over generations may have led to modifications in the HPI axis activity in B. variegata, resulting in adaptation to changes in water level, evident through the absence of stress response. Consequently, CORT may not be a relevant stress indicator in desiccation conditions for this species.

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Section: Discussionmentioning

confidence: 99%

The role of phenotypic plasticity and corticosterone in coping with pond drying conditions in yellow‐bellied toad (Bombina variegata, Linnaeus 1758) tadpoles

Kijanović,

Vukov,

Mirč

et al. 2024

J Exp Zool Pt A

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“…Most studies have used this technique to measure CORT release rates, which have been validated with circulating plasma levels (Gabor et al, 2013a). Waterborne sampling has evaluated CORT release rates in the presence or absence of Bd, predation, or pesticide exposure (Gabor et al, 2013b;Snyder et al, 2022) and can also be indicative of nitrate stress in amphibians (Ruthsatz et al, 2023). CORT is a potentially useful biomarker for amphibians to indicate stress, and non-invasive sampling methods offer the potential of serially sampling the same individual (Narayan et al, 2019;Tornabene et al, 2021).…”

Section: Sampling Strategiesmentioning

confidence: 99%

Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation

Awkerman,

Glinski,

Henderson

et al. 2024

Front. Ecol. Evol.

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Controlled laboratory experiments are often performed on amphibians to establish causality between stressor presence and an adverse outcome. However, in the field, identification of lab-generated biomarkers from single stressors and the interactions of multiple impacts are difficult to discern in an ecological context. The ubiquity of some pesticides and anthropogenic contaminants results in potentially cryptic sublethal effects or synergistic effects among multiple stressors. Although biochemical pathways regulating physiological responses to toxic stressors are often well-conserved among vertebrates, different exposure regimes and life stage vulnerabilities can yield variable ecological risk among species. Here we examine stress-related biomarkers, highlight endpoints commonly linked to apical effects, and discuss differences in ontogeny and ecology that could limit interpretation of biomarkers across species. Further we identify promising field-based physiological measures indicative of potential impacts to health and development of amphibians that could be useful to anuran conservation. We outline the physiological responses to common stressors in the context of altered functional pathways, presenting useful stage-specific endpoints for anuran species, and discussing multi-stressor vulnerability in the larger framework of amphibian life history and ecology. This overview identifies points of physiological, ecological, and demographic vulnerability to provide context in evaluating the multiple stressors impacting amphibian populations worldwide for strategic conservation planning.

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Stress and reproduction in amphibians

Carr

2024

Hormones and Reproduction of Vertebrates, Volume 2

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Contributions of water-borne corticosterone as one non-invasive biomarker in assessing nitrate pollution stress in tadpoles of Rana temporaria

Cited by 6 publications

References 103 publications

The role of phenotypic plasticity and corticosterone in coping with pond drying conditions in yellow‐bellied toad (Bombina variegata, Linnaeus 1758) tadpoles

The role of phenotypic plasticity and corticosterone in coping with pond drying conditions in yellow‐bellied toad (Bombina variegata, Linnaeus 1758) tadpoles

Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation

Stress and reproduction in amphibians

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