Contributions of the different rabbit models to our understanding of rotator cuff pathology

Gupta, Ranjan; Lee, Thay Q.

doi:10.1016/j.jse.2007.05.002

Cited by 63 publications

(56 citation statements)

References 33 publications

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“…First, this is an animal study and translation of these findings to the human should be made with caution. The rabbit rotator cuff model is well accepted for investigation of pathologic conditions of muscle because it reproduces the key structural findings for muscle deterioration seen in humans and sheep after detachment of its tendon [29][30][31][32] . This study focused exclusively on the muscle tissue and did not investigate the tendon, primarily because …”

Section: Discussionmentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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To our knowledge, this is the first documentation of partial prevention of important muscle alterations after retraction of the supraspinatus musculotendinous unit caused by tendon disruption. Nandrolone decanoate administration in the phase after tendon release prevented fatty infiltration of the supraspinatus muscle and reduced functional muscle impairment caused by myotendinous retraction in this rabbit rotator cuff model, but two of seven rabbits that received the drug developed infections. Background: Muscles of the rotator cuff undergo retraction, atrophy, and fatty infiltration after a chronic tear, and a rabbit

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Section: Discussionmentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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“…To better understand the pathogenesis of this biologic phenomenon, an animal model that can be used to accurately and quantitatively evaluate the evolution of rotator cuff injuries has been developed 13,14 . The rabbit subscapularis muscle has been shown to have similar anatomical and biomechanical properties to those of the human supraspinatus muscle (Fig.…”

mentioning

confidence: 99%

“…Limitations to the previous models include size of the animals, gait patterns, and variation in gross anatomy as compared with the anatomy of humans 13 . We made use of a rabbit model to validate the rabbit subscapularis muscle as a reproducible model for rotator cuff injury, examine the pathologic changes related to fat infiltration, and test our hypothesis that rotator cuff tenotomy creates an injury that is analogous to that seen with denervation of the muscle.…”

mentioning

confidence: 99%

Development of Fatty Atrophy After Neurologic and Rotator Cuff Injuries in an Animal Model of Rotator Cuff Pathology

Rowshan

Hadley

Pham

et al. 2010

Journal of Bone and Joint Surgery

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“…In conclusion, commonly used rotator cuff repair techniques can be recreated in the rabbit subscapularis with relative Time 0 results similar to human cadaveric data. This observation combined with the unique anatomic [20,21], histologic [38], and biomechanical similarities between the human supraspinatus and rabbit subscapularis provides evidence that the rabbit subscapularis is a viable animal model to study rotator cuff pathology.…”

Section: Discussionmentioning

confidence: 83%

“…Recent evidence suggests that the rabbit subscapularis tendon may be anatomically, biomechanically, and histologically suitable to study human rotator cuff pathology and repair [21]. The tendon passes under a tunnel composed laterally by the supraglenoidale tuberculum, medially by the coracobrachialis muscle, inferiorly by the infraglenoidale tuberculum, and superiorly by the coracoid processus before inserting on the lesser tubercle of the humerus.…”

Section: Introductionmentioning

confidence: 99%

Relative Fixation Strength of Rabbit Subscapularis Repair Is Comparable to Human Supraspinatus Repair at Time 0

Otarodifard

Wong

Preston

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Recent evidence suggests that the rabbit subscapularis tendon may be anatomically, biomechanically, and histologically suitable to study rotator cuff pathology and repair. However, biomechanical comparisons of rotator cuff repairs in this model have not been evaluated and compared to those in human cadaveric specimens. Questions/purposes We quantified the biomechanical properties of the repaired rabbit subscapularis tendon after (1) single-row, (2) double-row, and (3) transosseousequivalent rotator cuff repair techniques and compared the ratios of repairs to previously published data for human repairs.Methods Tensile testing was performed on 21 New Zealand White rabbit subscapularis tendon-humerus complexes for single-row repair, double-row repair, and transosseous-equivalent repair (n = 7 for each group). Video digitizing software was used to quantify deformation. Load elongation data were then used to quantify structural properties. We compared the ratios of rotator cuff repairs for the rabbit data to data from human supraspinatus repair studies previously performed in our laboratory. For our primary end points (linear stiffness, yield load, ultimate load, and energy absorbed to failure), with the numbers available, our statistical power to detect a clinically important difference (defined as 15%) was 85%. Results The ratios of single-row/double-row repair were 0.72, 0.73, 0.71, and 0.66 for human supraspinatus and 0.77, 0.74, 0.79, and 0.89 for rabbit subscapularis repair for linear stiffness, yield load, ultimate load, and energy absorbed to failure, respectively. The ratios of double-row/transosseousequivalent repair were 1.0, 0.86, 0.70, and 0.41 for human supraspinatus and 1.22, 0.85, 0.76, and 0.60 for rabbit subscapularis for linear stiffness, yield load, ultimate load, and energy absorbed to failure, respectively. There were no differences comparing rabbit to human repair ratios for any parameter (p [ 0.09 for all comparisons). Conclusions Subscapularis repairs in the rabbit at Time 0 result in comparable ratios to human supraspinatus repairs. Clinical Relevance The biomechanical similarities between the different types of rotator cuff repair in the rabbit subscapularis and human supraspinatus at Time 0 provide more evidence that the rabbit subscapularis may be an appropriate model to study rotator cuff repairs.

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Contributions of the different rabbit models to our understanding of rotator cuff pathology

Cited by 63 publications

References 33 publications

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Development of Fatty Atrophy After Neurologic and Rotator Cuff Injuries in an Animal Model of Rotator Cuff Pathology

Relative Fixation Strength of Rabbit Subscapularis Repair Is Comparable to Human Supraspinatus Repair at Time 0

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