Contributions of prefrontal cortex and hippocampal neuronal populations to altered behavioral responses to acute stress following HPA-axis disruption

Kinlein, Scott A.; Karatsoreos, Ilia N.

doi:10.1016/j.psyneuen.2015.07.563

Cited by 4 publications

(2 citation statements)

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“…For example, rearing QTL and plasma CORT responses to stress show overlap on Chromosome 2. The connection between HPA regulation and rearing in the OFT has been demonstrated [ 154 , 155 ], but the overlapping QTL suggests the genetic regulation of these phenotypes. While suggestive QTL are not listed in the table above, the stress glucose loci on Chromosome 5 also overlap a suggestive locus for stress CORT [ 146 , 151 ].…”

Section: Quantitative Trait Loci Analysesmentioning

confidence: 99%

The Wistar Kyoto Rat: A Model of Depression Traits

Redei

Udell

Solberg‐Woods

et al. 2023

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There is an ongoing debate about the value of animal research in psychiatry with valid lines of reasoning stating the limits of individual animal models compared to human psychiatric illnesses. Human depression is not a homogenous disorder; therefore, one cannot expect a single animal model to reflect depression heterogeneity. This limited review presents arguments that the Wistar Kyoto (WKY) rats show intrinsic depression traits. The phenotypes of WKY do not completely mirror those of human depression but clearly indicate characteristics that are common with it. WKYs present despair-like behavior, passive coping with stress, comorbid anxiety, and enhanced drug use compared to other routinely used inbred or outbred strains of rats. The commonly used tests identifying these phenotypes reflect exploratory, escape-oriented, and withdrawal-like behaviors. The WKYs consistently choose withdrawal or avoidance in novel environments and freezing behaviors in response to a challenge in these tests. The physiological response to a stressful environment is exaggerated in WKYs. Selective breeding generated two WKY substrains that are nearly isogenic but show clear behavioral differences, including that of depression-like behavior. WKY and its substrains may compare characteristics of subgroups of depressed individuals with social withdrawal, low energy, weight loss, sleep disturbances, and specific cognitive dysfunction. The genomes of the WKY and WKY substrains contain variations that impact the function of many genes identified in recent human genetic studies of depression. Thus, these strains of rats share characteristics of human depression at both phenotypic and genetic levels, making them a model of depression traits.

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Section: Quantitative Trait Loci Analysesmentioning

confidence: 99%

The Wistar Kyoto Rat: A Model of Depression Traits

Redei

Udell

Solberg‐Woods

et al. 2023

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“…Stress could lead to abnormalities in neural circuits related to cognition, decision-making, anxiety, and depression [26]. e prefrontal cortex and hippocampus are associated with mood-related symptoms of stress-related disorders [27] and their neuronal populations to altered behavioral responses to acute stress. As we knew, the prefrontal cortex and hippocampus are anatomically connected, and brain activity within them was relatively closely synchronized.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic Effect of Alcohol‐Water Extracted Suanzaoren‐Wuweizi Herb‐Pair by Regulating ECS‐BDNF‐ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats

Zhao

Liu

Shi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consists of two Chinese medicine herbs. The Suanzaoren-Wuweizi herb-pair (SWHP) is commonly used as a sedative or tranquilizer. SWHP has been demonstrated to exert an antianxiety effect in animal models of anxiety. However, little information about its mechanism is available and the effects of SWHP have not been investigated. This study examined the effects of SWHP on ameliorating anxiety-like behaviors by regulating endocannabinoids system (ECS)—brain-derived neurotrophic factor (BDNF)—extracellular regulated protein kinases (ERK) signaling pathway expression, induced by restraint stress (RS) procedures. The antianxiety effects of SWHP on RS rats were then examined through the open-field test (OF) and the elevated plus maze test (EPM). The concentration of BNDF, ERK1/2, p-ERK1/2, cAMP-response element binding protein (CREB), and p-CREB expression in the prefrontal cortex and hippocampus of the rats was then measured by western blot. The number of positive cells of CB1 and CB2 in the rats’ hippocampus CA1 region was measured by immunohistochemistry. These results gave compelling evidence that SWHP could modify anxiety-like behaviors of RS rats through regulation of the ECS-BDNF-ERK signaling pathway. Our study demonstrated that SWHP improved anxiety-like behaviors in RS rat models by regulating the ECS-BDNF-ERK signaling pathway. The findings indicate that SWHP may have a therapeutic application in the RS model of anxiety disorder, which proposes a potential new direction for research into anxiety disorders regarding mechanisms and the development of novel antianxiety drugs.

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