Contributions of Extracellular Vesicles to Fungal Biofilm Pathogenesis

Heredia, Marienela Y.; Andes, David R.

doi:10.1007/978-3-030-83391-6_7

Cited by 2 publications

(2 citation statements)

References 70 publications

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“…The high density of a biofilm community favors exchange of small molecules, including quorum-sensing signals and metabolic waste products ( 35 ). Sharing of extracellular vesicles also has a prominent impact on the biofilm phenotype ( 36 ). A simple hypothesis is that exchange of small molecules or vesicles rebalances or reconfigures cyclin activities, such that Ccn1 and Cln3 are more capable of assuming the function of Hgc1.…”

Section: Discussionmentioning

confidence: 99%

Hgc1 Independence of Biofilm Hyphae in Candida albicans

Sharma

Solis

Huang

et al. 2023

mBio

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Section: Discussionmentioning

confidence: 99%

Hgc1 Independence of Biofilm Hyphae in Candida albicans

Sharma

Solis

Huang

et al. 2023

mBio

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“…For biofilm formation of S. mutans , ficin reduced total biofilm proteins and decreased the molecular weight of isolated extracellular proteins, but did not affect bacterial growth and activity [ 17 ]. The extracellular matrix plays a vital role in mature C. albicans biofilm structures, in which the most abundant components are proteins (approximately 55%) [ 27 ]. Because it is a protease, the anti-biofilm effect of ficin might occur through degradation of extracellular proteins.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of ficin on Candida albicans biofilm formation and pre-formed biofilms

Wang

Shen

et al. 2022

BMC Oral Health

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Background To investigate the effect of ficin, a type of proteases, on Candida albicans (C. albicans) biofilm, including forming and pre-formed biofilms. Methods Crystal violet tests together with colony forming unit (CFU) counts were used to detect fungal biofilm biomass. Live/dead staining of biofilms observed by confocal laser scanning microscopy was used to monitor fungal activity. Finally, gene expression of C. albicans within biofilms was assessed by qRT-PCR. Results According to our results, biofilm biomass was dramatically reduced by ficin in both biofilm formation and pre-formed biofilms, as revealed by the crystal violet assay and CFU count (p < 0.05). Fungal activity in biofilm formation and pre-formed biofilms was not significantly influenced by ficin according to live/dead staining. Fungal polymorphism and biofilm associated gene expression were influenced by ficin, especially in groups with prominent antibiofilm effects. Conclusions In summary, ficin effectively inhibited C. albicans biofilm formation and detached its preformed biofilm, and it might be used to treat C. albicans biofilm associated problems.

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Contributions of Extracellular Vesicles to Fungal Biofilm Pathogenesis

Cited by 2 publications

References 70 publications

Hgc1 Independence of Biofilm Hyphae in Candida albicans

Hgc1 Independence of Biofilm Hyphae in Candida albicans

Inhibitory effect of ficin on Candida albicans biofilm formation and pre-formed biofilms

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