Contributions of electrophysiology for identifying cortical language systems in patients with epilepsy

Trébuchon, Agnès; Liégeois‐Chauvel, Catherine; González-Martínez, Jorge; Alario, F.‐Xavier

doi:10.1016/j.yebeh.2020.107407

Cited by 12 publications

(14 citation statements)

References 127 publications

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“…For language, using proper neuropsychological tasks during stimulation is of paramount importance because high order cortex is generally “silent” if not simultaneously tested. Failing to do so results in false negative conclusions and erroneous mapping ( Trébuchon et al, 2020 ). Language ESM studies have converged toward the segregation of three main functional regions coined anterior language area, posterior language area and basal temporal language area ( Schaffler et al, 1996 ; Trébuchon and Chauvel, 2016 ).…”

Section: Methodological Aspects Of Electrical Cortical Stimulation Usmentioning

confidence: 99%

Language Mapping Using Stereo Electroencephalography: A Review and Expert Opinion

Aron

Jonas

Colnat-Coulbois

et al. 2021

Front. Hum. Neurosci.

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Stereo-electroencephalography (sEEG) is a method that uses stereotactically implanted depth electrodes for extra-operative mapping of epileptogenic and functional networks. sEEG derived functional mapping is achieved using electrical cortical stimulations (ECS) that are currently the gold standard for delineating eloquent cortex. As this stands true especially for primary cortices (e.g., visual, sensitive, motor, etc.), ECS applied to higher order brain areas determine more subtle behavioral responses. While anterior and posterior language areas in the dorsal language stream seem to share characteristics with primary cortices, basal temporal language area (BTLA) in the ventral temporal cortex (VTC) behaves as a highly associative cortex. After a short introduction and considerations about methodological aspects of ECS using sEEG, we review the sEEG language mapping literature in this perspective. We first establish the validity of this technique to map indispensable language cortices in the dorsal language stream. Second, we highlight the contrast between the growing empirical ECS experience and the lack of understanding regarding the fundamental mechanisms underlying ECS behavioral effects, especially concerning the dispensable language cortex in the VTC. Evidences for considering network architecture as determinant for ECS behavioral response complexities are discussed. Further, we address the importance of designing new research in network organization of language as this could enhance ECS ability to map interindividual variability, pathology driven reorganization, and ultimately identify network resilience markers in order to better predict post-operative language deficit. Finally, based on a whole body of available studies, we believe there is strong evidence to consider sEEG as a valid, safe and reliable method for defining eloquent language cortices although there have been no proper comparisons between surgical resections with or without extra-operative or intra-operative language mapping.

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Section: Methodological Aspects Of Electrical Cortical Stimulation Usmentioning

confidence: 99%

Language Mapping Using Stereo Electroencephalography: A Review and Expert Opinion

Aron

Jonas

Colnat-Coulbois

et al. 2021

Front. Hum. Neurosci.

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“…A more lateralized brain allows for the development of a greater variety of centers that can individually process and control numerous functions, combining these individual centers into various networks leading to the unique cognitive abilities shared by humans. This lateralization develops with increasing age, brain, and nervous system development ( 87 – 93 ).…”

Section: Primitive Reflexes Neuronal Synchrony In Cortical Developmen...mentioning

confidence: 99%

“…Then the left hemisphere is significantly more greatly emphasized in development for the next 2–3 years of life. Once the differences and advantages are established during the first 6 years of life, this forms the basis of hemispheric specialization and lateralization that will increase throughout development ( 87 , 90 – 93 , 97 ).…”

Section: Primitive Reflexes Neuronal Synchrony In Cortical Developmen...mentioning

confidence: 99%

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

et al. 2022

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We provide evidence to support the contention that many aspects of Autistic Spectrum Disorder (ASD) are related to interregional brain functional disconnectivity associated with maturational delays in the development of brain networks. We think a delay in brain maturation in some networks may result in an increase in cortical maturation and development in other networks, leading to a developmental asynchrony and an unevenness of functional skills and symptoms. The paper supports the close relationship between retained primitive reflexes and cognitive and motor function in general and in ASD in particular provided to indicate that the inhibition of RPRs can effect positive change in ASD.

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“…At the same time, the procedure seeks to identify regions that need to be preserved in order to avoid post-surgical functional deficits (e.g. in language or memory abilities; Byrne, 2016;Lachaux et al, 2012;Trébuchon et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, the approach had to go beyond intuitions to provide a tool that allows systematic and reproducible analysis. The tool was developed and tested in the course of conducting various research projects (Anders et al, 2019;Dubarry et al, 2017;Trébuchon et al, 2020). We illustrate the use of the resulting MIA toolbox using a dataset from a group of patients performing a language task (previously reported in Dubarry et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

An open-source toolbox for Multi-patient Intracranial EEG Analysis (MIA)

Dubarry¹,

Liégeois‐Chauvel²,

Trébuchon³

et al. 2021

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Intracerebral stereotaxic electroencephalography (SEEG) performed during the pre-surgical evaluation of refractory epilepsy provides a formidable opportunity to investigate the neurophysiology of human cognitive functions with unrivaled spatial and temporal precision. A difficulty of the SEEG approach for cognitive neuroscience, however, is the potential variability across patients in the anatomical location of implantations and in the functional responses recorded. In this context, we designed, implemented, and tested a user-friendly and efficient open-source software for Multi-Patient Intracerebral data Analysis (MIA). The software helps performing the analysis of SEEG signals while following good scientific practice recommendations such as building reproducible analysis pipelines and applying robust statistics. The signals can be analyzed in the temporal and time-frequency domains and the similarity of time courses can be assessed within anatomical regions, while visualizing the results in a variety of formats at every step of the analysis. Here, we illustrate the different features and steps of the analysis pipeline using a group dataset collected in a language task.

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Contributions of electrophysiology for identifying cortical language systems in patients with epilepsy

Cited by 12 publications

References 127 publications

Language Mapping Using Stereo Electroencephalography: A Review and Expert Opinion

Language Mapping Using Stereo Electroencephalography: A Review and Expert Opinion

Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders

An open-source toolbox for Multi-patient Intracranial EEG Analysis (MIA)

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