Contributions A L'Étude des Variations Physiologiques De La Sécrétion Interne Du Pancréas

Zunz, Edgard; Barre, Jean La

doi:10.3109/13813452909145169

Cited by 42 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of gut-endocrine pancreas interaction on glucose metabolism was first recognized by Claude Bernard about a century ago[23] and further conceptualized by Zunz and La Barre who introduced the term "incretins", which describe a family of hypoglycemic factors found in the extract of duodenum[24]. On the basis of understanding of the influence of the gut on pancreatic islet functions, in 1969, Unger and Eisentraut integrated these notions under a single concept of "entero-insular axis"[25].…”

Section: Discussionmentioning

confidence: 99%

Effect of catch-up growth after food restriction on the entero-insular axis in rats

et al. 2010

View full text Add to dashboard Cite

BackgroundCatch-up growth after food restriction (CUGFR) is characterized by a significant change in food intake which could theoretically lead to the change in glucagon-like peptide-1 (GLP-1) secretion that consequently results in altered functions of pancreatic islets.MethodsExperimental rats were divided into two groups. Rats in CUGFR group were put on food-restriction for 4 weeks, and then allowed full access to food for 0, 2, 4 weeks respectively while rats in the control group were offered ad libitum access to food. Plasma glucose, insulin and GLP-1 level during OGTT were measured in all the rats. Moreover, morphology of intestinal mucosa, number of L cells, beta cell mass, incretin effect and the expression of GLP-1 receptor (GLP-1R) gene in the islets were also determined.ResultsThe size of pancreatic islets, insulin concentration, plasma GLP-1 concentration, incretin effect, villus height-to-crypt depth ratio and L cells were all significantly decreased in CUGFR group at the end of a 4-week food-restriction period as compared with the controls. Insulin concentration and the villus height-to-crypt depth ratio were increased and finally exceeded the level of the control group over a 4-week catch-up period. Nevertheless, at the conclusion of the study, islet size, L cells number, plasma GLP-1 concentration and incretin effect increased but failed to reach the levels of the controls.ConclusionCUGFR decreases incretin effect and disturbs the entero-insular axis partially by decreasing GLP-1 concentration, which might be responsible for the increased risk of metabolic disorder during CUGFR.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of catch-up growth after food restriction on the entero-insular axis in rats

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Glucose-dependent insulinotropic polypeptide (GIP) was the first gut hormone [10] to be isolated in 1970-1975 [20]. GIP and glucagon-like peptide-1 (GLP-1), the second intestinal hormones discovered, are called incretins [21], as they improve the insulin response after oral glucose administration, compared to that obtained following intravenous administration [1,22,23]. GIP is a 42-amino acid polypeptide secreted from enteroendocrine K-cells that are found in the small intestinal epithelium [24,25].…”

Section: Gip Physiology: Similarities and Differences Versus Glp-1mentioning

confidence: 99%

“…The discovery of the incretin dates to 1929 due to the work of La Barre [1], but the true pioneers of the incretin concept were Bayliss and Moore 20 years earlier, when they hypothesized that the endocrine pancreas secretion was regulated by hormones contained in the gut extracts [2,3]. Incretin was forgotten for three decades until the discovery by McIntyre [4] that stated that intestines released some humoral substances, after glucose ingestion, that helped to promote β-cellular secretion of insulin, followed by the introduction by Unger and Eisentrout of the concept of "entero-insular axis" [5].…”

Section: Introductionmentioning

confidence: 99%

Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment

Pelle

Provenzano

Zaffina

et al. 2021

Life

View full text Add to dashboard Cite

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two gut hormones, defined incretins, responsible for the amplification of insulin secretion after oral glucose intake. Unlike GLP-1, GIP has little acute effect on insulin secretion and no effect on food intake; instead it seems that the GIP may be an obesity-promoting hormone. In patients with type2 diabetes mellitus (T2DM) some studies found a downregulation of GIP receptors on pancreatic β cells caused by hyperglycemic state, but the glucagonotropic effect persisted. Agonists of the receptor for the GLP-1 have proven successful for the treatment of diabetes, since they reduce the risk for cardiovascular and renal events, but the possible application of GIP as therapy for T2DM is discussed. Moreover, the latest evidence showed a synergetic effect when GIP was combined with GLP-1 in monomolecular co-agonists. In fact, compared with the separate infusion of each hormone, the combination increased both insulin response and glucagonostatic response. In accordance with theseconsiderations, a dual GIP/GLP-1receptor agonist, i.e., Tirzepatide, known as a “twincretin” had been developed. In the pre-clinical trials, as well as Phase 1–3 clinical trials, Tirzepatideshowedpotent glucose lowering and weight loss effects within an acceptable safety.

show abstract

Effects of Hypoglycemia and Anoxia on the Central Nervous System

Gellhorn¹

1938

Arch NeurPsych

View full text Add to dashboard Cite

Contributions A L'Étude des Variations Physiologiques De La Sécrétion Interne Du Pancréas

Cited by 42 publications

References 10 publications

Effect of catch-up growth after food restriction on the entero-insular axis in rats

Effect of catch-up growth after food restriction on the entero-insular axis in rats

Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment

Effects of Hypoglycemia and Anoxia on the Central Nervous System

Contact Info

Product

Resources

About