Pulmonary embolism (PE) can only be diagnosed with imaging techniques, which in practice is performed using ventilation/perfusion scintigraphy(V/P scintigraphy) or multi-detector computed tomography of the pulmonary arteries (MDCT). The basic principle for the diagnosis of PE based upon V/P scintigraphy is to recognize lung segments or subsegments without perfusion but preserved ventilation, i. e. mismatch. Ventilation/ perfusion single photon emission tomography-V/P SPECT has during the last 10 years started to replace V/P planar based on higher sensitivity, specificity and low non-diagnostic findings. A twenty seven year old woman was suspected for PE when presented to the outpatient clinic due to dyspnea, frequent yawing, oppression in the throat, 3 days after being treated of superficial varices cruris with foam sclerotherapy-UGFS. She was first examined with chest x-ray, MDCT, hearth ultrasonography and V/P planar. V/P planar was reported as very low probability for PE. All the other initial examinations were normal. Patient symptoms did not decline, and reffering clinitian put her on therapy with LMWH.