Contribution of Tumor Endothelial Cells in Cancer Progression

Hida, Kyoko; Maishi, Nako; Annan, Dorcas A.; Hida, Yasuhiro

doi:10.3390/ijms19051272

Cited by 206 publications

(165 citation statements)

References 77 publications

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“…109 Whether tumor angiogenesis is directly associated with increased metastatic risk is a subject of great debate, although it is generally accepted that tumor endothelial cells (TECs) contribute to critical steps of the metastatic cascade. 185,186 The association of angiogenesis with tumor metastasis seems to be due to interaction of TECs with TIE2 + TAMs accumulated after chemotherapy at perivascular sites, which increases TMEM assembly and function. 137 Although the current review focuses on chemotherapy, it should also be noted that a growing number of studies reported that TAMs limit the efficacy of anti-angiogenic therapies, mostly because TAMs shift the "angiogenic switch" toward the pro-angiogenic side.…”

Section: Chemotherapy-induced Angiogenesismentioning

confidence: 99%

The emerging roles of macrophages in cancer metastasis and response to chemotherapy

Sanchez

Borriello

Entenberg

et al. 2019

Journal of Leukocyte Biology

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Macrophages represent a heterogeneous group of cells, capable of carrying out distinct functions in a variety of organs and tissues. Even within individual tissues, their functions can vary with location. Tumor‐associated macrophages (TAMs) specialize into three major subtypes that carry out multiple tasks simultaneously. This is especially true in the context of metastasis, where TAMs establish most of the cellular and molecular prerequisites for successful cancer cell dissemination and seeding to the secondary site. Perivascular TAMs operate in the perivascular niche, where they promote tumor angiogenesis and aid in the assembly of intravasation sites called tumor microenvironment of metastasis (TMEM). Streaming TAMs co‐migrate with tumor cells (irrespective of the perivascular niche) and promote matrix remodeling, tumor cell invasiveness, and an immunosuppressive local microenvironment. Premetastatic TAMs are recruited to the premetastatic niche, where they can assist in tumor cell extravasation, seeding, and metastatic colonization. The dynamic interplay between TAMs and tumor cells can also modify the ability of the latter to resist cytotoxic chemotherapy (a phenotype known as environment‐mediated drug resistance) and induce chemotherapy‐mediated pro‐metastatic microenvironmental changes. These observations suggest that future therapeutics should be designed to target TAMs with the aim of suppressing the metastatic potential of tumors and rendering chemotherapy more efficient.

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Section: Chemotherapy-induced Angiogenesismentioning

confidence: 99%

The emerging roles of macrophages in cancer metastasis and response to chemotherapy

Sanchez

Borriello

Entenberg

et al. 2019

Journal of Leukocyte Biology

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“…angiogenesis, colorectal cancer, endothelial cells, integrin β1, sorting nexin 9 1 | INTRODUCTION One of the hallmarks in the development of solid tumors is tumor angiogenesis, the process of new blood vessel growth in tumor tissues from the pre-existing vasculatures (Folkman, 1971;Hida, Maishi, Annan, & Hida, 2018). The angiogenic activity of endothelial cells arises in response to various growth factors such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor released from the neighboring tumor cells (Carmeliet & Jain, 2011).…”

Section: Introductionmentioning

confidence: 99%

SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9

Tanigawa

Maekawa

Kiyoi

et al. 2019

Journal Cellular Physiology

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Angiogenesis, the formation of new blood vessels, is involved in a variety of diseases including the tumor growth. In response to various angiogenic stimulations, a number of proteins on the surface of vascular endothelial cells are activated to coordinate cell proliferation, migration, and spreading processes to form new blood vessels. Plasma membrane localization of these angiogenic proteins, which include vascular endothelial growth factor receptors and integrins, are warranted by intracellular membrane trafficking. Here, by using a siRNA library, we screened for the sorting nexin family that regulates intracellular trafficking and identified sorting nexin 9 (SNX9) as a novel angiogenic factor in human umbilical vein endothelial cells (HUVECs). SNX9 was essential for cell spreading on the Matrigel, and tube formation that mimics in vivo angiogenesis in HUVECs. SNX9 depletion significantly delayed the recycling of integrin β1, an essential adhesion molecule for angiogenesis, and reduced the surface levels of integrin β1 in HUVECs. Clinically, we showed that SNX9 protein was highly expressed in tumor endothelial cells of human colorectal cancer tissues. High‐level expression of SNX9 messenger RNA significantly correlated with poor prognosis of the patients with colorectal cancer. These results suggest that SNX9 is an angiogenic factor and provide a novel target for the development of new antiangiogenic drugs.

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“…However, the same tumor cells can secrete immunosuppressive factors, controlling the immune response [68][69][70] . Tumor-associated endothelial cells also contribute to make cancer physically inaccessible to the immune system by increasing deposition of factors that, on the one hand, confer a higher stiffness of the extracellular matrix and, on the other hand, prevent immune infiltration in the tumor tissue and favor tumor cell proliferation [69,71] . In light of these findings, several different immunotherapeutic strategies have been developed.…”

Section: Role Of Immunity In Resistancementioning

confidence: 99%

Cancer stem cells, plasticity, and drug resistance

Lionetti¹,

Fumagalli²,

Porta³

2020

CDR

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Melanoma is a highly aggressive tumor and almost always fatal when metastatic. Herein, we discuss recent findings on the mechanisms of resistance of human cutaneous melanoma. To achieve a precision medicine approach, the heterogeneity and plasticity of tumor cells are two crucial aspects to be investigated in depth. In fact, to understand the mechanisms that cells use to acquire a resistant phenotype after chemotherapy or how resistant cells inside the tumor are selected, it is the most important issue for a successful therapy. Since new therapeutic strategies are trying to go in this direction, we discuss here the state of the art of the research and the clinical impact of these strategies. We also discuss and suggest future research directions to develop approaches able to define the best concentration and time of exposure of the drug or the cocktails of drugs for each specific patient based on his/her biological features.Melanoma arises from mutated melanocytes, the pigment producing cells. Although melanoma is a rare tumor, occurring in about 1% of all skin malignant tumors, it represents almost 2% of all cancer deaths worldwide [1] ; the survival rate is strictly related to the stage of the tumor and thus to the ability to perform

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Contribution of Tumor Endothelial Cells in Cancer Progression

Cited by 206 publications

References 77 publications

The emerging roles of macrophages in cancer metastasis and response to chemotherapy

The emerging roles of macrophages in cancer metastasis and response to chemotherapy

SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9

Cancer stem cells, plasticity, and drug resistance

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