Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line models

Severino, Paulo F.; Carrascal, Mylène A.; Gouveia, Helena; Cabral, M. Guadalupe; Correia, Mesaque Silva; Malagolini, Nadia; Chiricolo, Mariella; Dall’Olio, Fabio; Videira, Paula A.

doi:10.1186/1753-6561-4-s2-p48

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In epithelial cells, the TF is carried by mucin-1 (MUC1) on the apical surface. In tumor cells, MUC1 is post-translationally modified resulting in aberrant O-glycosylation, such as TF, a well-defined antigen with a proven link to epithelial-based carcinomas but not in normal tissues 14–15 , including bladder 16 , colorectal 17 , gastrointestinal 18 , prostate 19–20 , ovarian 21 and lung 22 and pancreatic 23–25 carcinomas. The TF antigen is most noteworthy for its overexpression in tumors at a rate far more frequent than for other oncogene products, such as myc, ras k or HER2/neu, and it has a greater correlation with tumor progress than that of tumor-suppressing genes such as p53 or p16 26 .…”

Section: Introductionmentioning

confidence: 99%

Specific Molecular Recognition as a Strategy to Delineate Tumor Margin Using Topically Applied Fluorescence Embedded Nanoparticles

Barton

Siuta

et al. 2018

prnano

View full text Add to dashboard Cite

The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report the development of multimodal imaging probe, the tripolymer fluorescent nanospheres, whose surface was fabricated with peanut agglutinin (PNA) moieties as TF molecular recognition molecules. Here, we demonstrate that the probe is able to detect TF antigen in human pancreatic cancer tissues and differentiate from normal tissue. What is most noteworthy regarding the probe is its ability to visualize tumor margins defined by epithelial TF antigen expression. Further, in vivo preclinical studies using an orthotopic mouse model of pancreatic cancer suggest the potential use of the nanospheres for laparoscopic imaging of pancreatic cancer tumor margins to enhance surgical resection and improve clinical outcomes.

show abstract