Contribution of therapeutic education in the treatment of knee osteoarthritis: Preliminary results

Hamad, W. Haj; Sghir, M.; Guedria, Mohamed; Maraoui, M; Said, Wafa; Jerbi, Saïda; Kessomtini, W.

doi:10.1016/j.rehab.2016.07.352

Cited by 2 publications

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“…Tuina can also relieve the pathological fatigue of muscles, restore the physiological balance of muscles and bones [26], regulate the expression of TNF-α, MMP-13, integrin α1, and integrin β1 to inhibit the apoptosis of chondrocytes, promote the metabolism of cartilage extracellular matrix, and inhibit the degeneration of articular cartilage [27]. Moreover, numerous domestic and foreign studies have also shown that education is conducive to the treatment of KOA [28][29][30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Cerebral mechanism of Tuina analgesia in management of knee osteoarthritis using multimodal MRI: study protocol for a randomised controlled trial

Guo

Kong

Zhu

et al. 2022

Trials

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Background The chronic pain of patients with knee osteoarthritis (KOA) seriously affects their quality of life and leads to heavy social and economic burden. As a nondrug therapy in Traditional Chinese Medicine (TCM), Tuina is generally recognised as safe and effective for reducing the chronic pain of KOA. However, the underlying central mechanisms of Tuina for improving the pain of KOA are not fully understood. Methods/design This study will be a randomised controlled trial with a parallel-group design. A total of 60 eligible participants will be assigned to the Tuina group or healthcare education group (Education group) at 1:1 ratio using stratified randomisation with gender and age as factors. The interventions of both groups will last for 30 min per session and be conducted twice each week for 12 weeks. This study will primarily focus on pain evaluation assessed by detecting the changes in brain grey matter (GM) structure, white matter (WM) structure, and the cerebral functional connectivity (FC) elicited by Tuina treatment, e.g., thalamus, hippocampus, anterior cingulate gyrus, S1, insula, and periaqueductal grey subregions (PAG). The two groups of patients will be evaluated by clinical assessments and multimodal magnetic resonance imaging (MRI) to observe the alterations in the GM, WM, and FC of participants at the baseline and the end of 6 and 12 weeks’ treatment and still be evaluated by clinical assessments but not MRI for 48 weeks of follow-up. The visual analogue scale of current pain is the primary outcome. The Short-Form McGill Pain Questionnaire, Western Ontario and McMaster Universities Osteoarthritis Index, 36-Item Short Form Health Survey, Hamilton Depression Scale, and Hamilton Anxiety Scale will be used to evaluate the pain intensity, pain feeling, pain emotion, clinical symptoms, and quality of life, respectively. MRI assessments, clinical data evaluators, data managers, and statisticians will be blinded to the group allocation in the outcome evaluation procedure and data analysis to reduce the risk of bias. The repeated measures analysis of variance (2 groups × 6 time points ANOVA) will be used to analyse numerical variables of the clinical and neuroimaging data obtained in the study. P<0.05 will be the statistical significance level. Discussion The results of this randomised controlled trial with clinical assessments and multimodal MRI will help reveal the influence of Tuina treatment on the potential morphological changes in cortical and subcortical brain structures, the white matter integrity, and the functional activities and connectivity of brain regions of patients with KOA, which may provide scientific evidence for the clinical application of Tuina in the management of KOA. Trial registration Chinese Clinical Trial Registry ChiCTR2000037966. Registered on Sep. 8, 2020. Dissemination The results will be published in peer-reviewed journals and disseminated through the study’s website, and conferences.

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Section: Introductionmentioning

confidence: 99%

Cerebral mechanism of Tuina analgesia in management of knee osteoarthritis using multimodal MRI: study protocol for a randomised controlled trial

Guo

Kong

Zhu

et al. 2022

Trials

View full text Add to dashboard Cite

show abstract

“…Tuina also can relieve the pathological fatigue of muscles, restore the physiological balance of muscles and bones [20], regulate the expression of TNF-α, MMP-13, integrin α1 and integrin β1 to inhibit the apoptosis of chondrocytes, promote the metabolism of cartilage extracellular matrix, and inhibit the degeneration of articular cartilage [21]. In addition, a large number of domestic and foreign studies have also shown that education is conducive to the treatment of KOA [22,23].…”

Section: Introductionmentioning

confidence: 99%

Cerebral Mechanism of Tuina Analgesia in Management of Knee Osteoarthritis using multimodal MRI: Study Protocol for a Randomized Controlled Trial

Guo

Kong

Zhu

et al. 2021

Preprint

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Background: Chronic pain of patients with knee osteoarthritis (KOA) seriously affects the quality of life and leads to the heavy social and economic burden. As one of the representative non-drug therapies in Traditional Chinese Medicine (TCM), Tuina has been generally recognized as safe and effective for reducing the chronic pain of KOA, however the underlying central mechanisms of Tuina for improving the pain of KOA are not fully understood.Methods/design: This study is a randomized controlled trial with parallel-group design. In total, 60 eligible participants will be randomly assigned to a Tuina group and a health care education group (Education group) in a 1:1 ratio with gender and age matched. The interventions of both groups will last for 30 min per session and be conducted twice each week for 12 weeks. This study will focus on detecting the changes of brain gray matter structure (GM), white matter structure (WM), the cerebral functional connectivity (FC) elicited by Tuina treatment, e.g thalamus, hippocampus, anterior cingulate gyrus, S1, insula, the periaqueductal gray subregions (PAG) etc. The two groups of patients will be evaluated by clinical assessments and multimodal magnetic resonance imaging (MRI) at the baseline and the end of 6 and 12 weeks’ treatment, and still be evaluated by clinical assessments for 48 weeks of follow-up. The Visual Analog Scale (VAS) of current pain, Short-form McGill Pain Questionnaire (SF-MPQ), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the 36-Item Short Form Health Survey (SF-36), Hamilton Depression Scale (HAMD) and the Hamilton Anxiety Scale (HAMA) will be used to evaluate the pain intensity, pain feeling, pain emotion, clinical symptoms and quality of life respectively. The evaluators and statisticians will be blinded to the group allocation. The repeated measures analysis of variance (2 groups × 6 time points ANOVA) will be employed to analyze numerical variables of the clinical and neuroimaging data obtained in the study. P<0.05 will be the statistical significance level. Discussion: The results of this randomized controlled trial with clinical assessments and multimodal MRI will help to reveal the influence of Tuina treatment on the potential morphological changes of cortical and subcortical brain structures, the white matter integrity and the functional activities and connectivity of brain regions of patients with KOA, which might provide scientific evidence for the clinical application of Tuina in management of KOA.Trial registration: Chinese Clinical Trial Registry: ChiCTR2000037966. Date of Registration: 8, Sep. 2020. http://www.chictr.org.cn/edit.aspx?pid=61083&htm=4

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Contribution of therapeutic education in the treatment of knee osteoarthritis: Preliminary results

Cited by 2 publications

References 0 publications

Cerebral mechanism of Tuina analgesia in management of knee osteoarthritis using multimodal MRI: study protocol for a randomised controlled trial

Cerebral mechanism of Tuina analgesia in management of knee osteoarthritis using multimodal MRI: study protocol for a randomised controlled trial

Cerebral Mechanism of Tuina Analgesia in Management of Knee Osteoarthritis using multimodal MRI: Study Protocol for a Randomized Controlled Trial

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