Contribution of the suprachiasmatic nucleus to day:night variation in cocaine-seeking behavior

Sleipness, Evan P.; Sorg, Barbara A.; Jansen, Heiko T.

doi:10.1016/j.physbeh.2007.02.013

Cited by 34 publications

(26 citation statements)

References 38 publications

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“…Indeed, it was discovered that the SCN is at least partially responsible for the presence of normal day/night differences in dopamine transporter and tyrosine hydroxylase protein expression in the nucleus accumbens, mPFC, and caudate (Sleipness et al, 2007b). A contribution of the SCN in the day/night variation in cocaine-seeking behavior in rats has also been reported (Sleipness et al, 2007a). It is interesting to consider that these rhythms might share a common ground with learning and memory processes whose methodological considerations include a reward step necessary for the establishment of the behavior.…”

Section: Discussionmentioning

confidence: 99%

Circadian modulation of interval timing in mice

et al. 2011

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Temporal perception is fundamental to environmental adaptation in humans and other animals. To deal with timing and time perception, organisms have developed multiple systems that are active over a broad range of order of magnitude, the most important being circadian timing, interval timing and millisecond timing. The circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is driven by a selfsustaining oscillator with a period close to 24 h. Time estimation in the second-to-minutes range -known as interval timing -involves the interaction of the basal ganglia and the prefrontal cortex. In this work we tested the hypothesis that interval timing in mice is sensitive to circadian modulations. Animals were trained following the peak-interval (PI) procedure. Results show significant differences in the estimation of 24-second intervals at different times of day, with a higher accuracy in the group trained at night, which were maintained under constant dark (DD) conditions. Interval timing was also studied in animals under constant light (LL) conditions, which abolish circadian rhythmicity. Mice under LL conditions were unable to acquire temporal control in the peak interval procedure.Moreover, short time estimation in animals subjected to circadian desynchronizations (modeling jet lag-like situations) was also affected. Taken together, our results indicate that short-time estimation is modulated by the circadian clock.© 2010 Elsevier B.V. All rights reserved. Keywords:Circadian rhythms Interval timingBasal ganglia Suprachiasmatic nuclei IntroductionTiming and time perception are fundamental to survival and goal reaching in humans and other animals. Organisms have developed diverse mechanisms for timing across different scales, the most important being circadian timing, interval timing and millisecond timing . The circadian pacemaker -which is driven by a self-sustaining oscillator with a period close to 24 h -is located in the suprachiasmatic nuclei (SCN) of the hypothalamus (Dunlap et al., 2004), and the principal signal that adjusts its activity is the light-dark cycle (Morin and Allen, 2006;Golombek and Rosenstein, 2010). The molecular mechanism of the endogenous circadian clock is comprised by interlocked transcription-translation feedback loops (Reppert and Weaver, 2002). On the other hand, the perception of shorter durations in the seconds-to-minutes range, known as interval timing, is crucial to learning, memory, decision making and other cognitive

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Section: Discussionmentioning

confidence: 99%

Circadian modulation of interval timing in mice

et al. 2011

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“…This suggests that the SCN is exerting inhibitory control over dopamine rhythms in the NAc. However, it is possible that an extra-SCN oscillator is responsible for regulating circadian variation in specific drug-related behaviors (Sleipness, Sorg, & Jansen, 2007a). …”

Section: Circadian Control Of Brain Reward Mechanismsmentioning

confidence: 99%

Circadian rhythms and addiction: Mechanistic insights and future directions.

Logan

Williams

McClung

2014

Behavioral Neuroscience

115

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Circadian rhythms are prominent in many physiological and behavioral functions. Circadian disruptions either by environmental or molecular perturbation can have profound health consequences, including the development and progression of addiction. Both animal and humans studies indicate extensive bidirectional relationships between the circadian system and drugs of abuse. Addicted individuals display disrupted rhythms, and chronic disruption or particular chronotypes, may increase the risk for substance abuse and relapse. Moreover, polymorphisms in circadian genes and an evening chronotype have been linked to mood and addiction disorders, and recent efforts suggest an association with the function of reward neurocircuitry. Animal studies are beginning to determine how altered circadian gene function results in drug induced neuroplasticity and behaviors. Many studies suggest a critical role for circadian rhythms in reward-related pathways in the brain and indicate that drugs of abuse directly affect the central circadian pacemaker. In this review, we highlight key findings demonstrating the importance of circadian rhythms in addiction, and how future studies will reveal important mechanistic insights into the involvement of circadian rhythms in drug addiction.

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“…For example, studies with clonidine used for ADHD or as an anesthetic have provided in-depth knowledge on sleep-wake and cognition regulatory functions through the study of binding on pre-and postsynaptic α 2 adrenergic receptors (see for reviews: Arnsten et al, 1996;Berridge and Devilbiss, 2011). Another example relates to disruption of circadian rhythms in dopaminergic concentration and receptor activity which have been linked to circadian symptomatology in drug addiction (Falcon and McClung, 2009;Naber et al, 1980;Sleipness et al, 2007). In their review, Manev and Uz (2009) reported time-dependent behavioral actions of both cocaine and amphetamines.…”

Section: Prediction 1: Adhd Is Associated With Lc-mediated Circadian mentioning

confidence: 99%

Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

Imeraj

Sonuga‐Barke

Antrop

et al. 2012

Neuroscience & Biobehavioral Reviews

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and (iv) rhythmicity in neuroendocrine and neurophysiological responsiveness. On this basis, we propose a neurobiological framework to guide future study, which sees circadian effects in ADHD, along with other aspects of ADHD arousal-related deficits (e.g., cognitive energetic deficits), as being the result of dysregulated locus coeruleus function. Based on this perspective specific recommendations for future research are presented.

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Contribution of the suprachiasmatic nucleus to day:night variation in cocaine-seeking behavior

Cited by 34 publications

References 38 publications

Circadian modulation of interval timing in mice

Circadian modulation of interval timing in mice

Circadian rhythms and addiction: Mechanistic insights and future directions.

Altered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies

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