Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit

Wang, Y.; Eshwaran, Rachana; Beck, Susanne; Hammes, Hans‐Peter; Wieland, Thomas; Feng, Yuxi

doi:10.1016/j.molmet.2023.101736

Molecular Metabolism

2023

DOI: 10.1016/j.molmet.2023.101736

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Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit

Y. Wang

Rachana Eshwaran

Susanne Beck

et al.

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2024

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Cited by 3 publications

References 151 publications

(197 reference statements)

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Role of O-GlcNAcylation in Central Nervous System Development and Injuries: A Systematic Review

Zhang,

Bai,

Peng

et al. 2024

Mol Neurobiol

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Role of O-GlcNAcylation in Central Nervous System Development and Injuries: A Systematic Review

Zhang,

Bai,

Peng

et al. 2024

Mol Neurobiol

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mTOR Dysregulation, Insulin Resistance, and Hypertension

Stanciu,

Jinga,

Miricescu

et al. 2024

Biomedicines

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Worldwide, diabetes mellitus (DM) and cardiovascular diseases (CVDs) represent serious health problems associated with unhealthy diet and sedentarism. Metabolic syndrome (MetS) is characterized by obesity, dyslipidemia, hyperglycemia, insulin resistance (IR) and hypertension. The mammalian target of rapamycin (mTOR) is a serine/threonine kinase with key roles in glucose and lipid metabolism, cell growth, survival and proliferation. mTOR hyperactivation disturbs glucose metabolism, leading to hyperglycemia and further to IR, with a higher incidence in the Western population. Metformin is one of the most used hypoglycemic drugs, with anti-inflammatory, antioxidant and antitumoral properties, having also the capacity to inhibit mTOR. mTOR inhibitors such as rapamycin and its analogs everolimus and temsirolimus block mTOR activity, decrease the levels of glucose and triglycerides, and reduce body weight. The link between mTOR dysregulation, IR, hypertension and mTOR inhibitors has not been fully described. Therefore, the main aim of this narrative review is to present the mechanism by which nutrients, proinflammatory cytokines, increased salt intake and renin–angiotensin–aldosterone system (RAAS) dysregulation induce mTOR overactivation, associated further with IR and hypertension development, and also mTOR inhibitors with higher potential to block the activity of this protein kinase.

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Effect of propylene glycol mannate sulfate on non-proliferative diabetic retinopathy

Wang

2024

Am J Transl Res

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Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit

Cited by 3 publications

References 151 publications

Role of O-GlcNAcylation in Central Nervous System Development and Injuries: A Systematic Review

Role of O-GlcNAcylation in Central Nervous System Development and Injuries: A Systematic Review

mTOR Dysregulation, Insulin Resistance, and Hypertension

Effect of propylene glycol mannate sulfate on non-proliferative diabetic retinopathy

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