Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish
Clair Chaigne,
Dora Sapède,
Xavier Cousin
et al.
Abstract:The eye is instrumental for controlling circadian rhythms in mice and human. Here, we address the conservation of this function in the zebrafish, a diurnal vertebrate. Using lakritz (lak) mutant larvae, which lack retinal ganglion cells (RGCs), we show that while a functional eye contributes to masking, it is largely dispensable for the establishment of circadian rhythms of locomotor activity. Furthermore, the eye is dispensable for the induction of a phase delay following a pulse of white light at CT 16 but c… Show more
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