Contribution of surgery in patients with bulky residual disease after chemoradiation for advanced cervical carcinoma

Houvenaeghel, Gilles; Lelièvre, L.; Buttarelli, M.; Jacquemier, Jocelyne; Carcopino, Xavier; Viens, Patrice; Gonzague-Casabianca, L.

doi:10.1016/j.ejso.2006.10.011

Cited by 66 publications

(61 citation statements)

References 13 publications

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“…None of them has suspicious local lymphnodes. The reported 5-year OS in the surgery group was 64.9 percent for stages higher than IIB (19).…”

Section: • Surgery As Primary Treatment For Cervical Cancermentioning

confidence: 86%

Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review

Nițipir¹,

Orlov²,

Popa³

et al. 2018

J Clin Invest Surg.

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Objective. The purpose of this paper is to review the current concepts in the literature regarding the beneficial effects of adjuvant surgery after concurrent radio-chemotherapy for locally advanced cervical cancer. Method.Research of the literature was performed using PubMed databases in order to find articles relevant to the central topic. The PICOS criteria were used to filter the results. The paper was then structured according to the PRISMA guideline.Results. 50 individual papers were analyzed and sorted according to their relevance for the topic. 18 were classified as relevant. There was little agreement as to how beneficial adjuvant hysterectomy is in locally advanced cervical cancer after chemoradiotherapy. Some articles concluded that patients with a total clinical response after initial treatment might have superior progression-free survival and overall survival after surgery. 2 articles underlined the importance of accurate restaging after primary treatment. The lack of benefit for surgery in patients with bulky disease or persistent adenopathies was agreed upon in all cases. Conclusions.The decision for adjuvant hysterectomy with or without lymphadenectomy is a controversial one and has to be personalized and taken in a multidisciplinary team.

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“…None of them has suspicious local lymphnodes. The reported 5-year OS in the surgery group was 64.9 percent for stages higher than IIB (19).…”

Section: • Surgery As Primary Treatment For Cervical Cancermentioning

confidence: 86%

Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review

Nițipir¹,

Orlov²,

Popa³

et al. 2018

J Clin Invest Surg.

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“…A postchemoradiation extrafascial hysterectomy was part of the treatment in GOG123 [46], the work by Keys et al [24], and in single-institution studies [1,5,22,25,32,44]. The concern that this leads to an excess in toxicity was not confirmed in recent series [5,25] while a significant benefit toward local control [24,25,32], progression-free survival [25] and a favorable trend toward overall survival were suggested [5,25].…”

Section: Discussionmentioning

confidence: 99%

“…The rate of residual tumor in hysterectomy specimens after chemoradiation followed by "conventional" brachytherapy is 45-61% [1,5,25,32,44]. Residual tumor increases the rate of pelvic recurrence [5,22,39] and reduces progression-free survival [25].…”

Section: Introductionmentioning

confidence: 99%

Intensity-Modulated Arc Therapy with Simultaneous Integrated Boost in the Treatment of Primary Irresectable Cervical Cancer

et al. 2009

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“…In our institution, radical hysterectomy is not performed systematically in small cancers of the cervix [1,2]. In stage \TIB2, simple colpohysterectomy is performed after brachytherapy to avoid urinary morbidity.…”

Section: Methodsmentioning

confidence: 99%

Robot-assisted laparoscopy in gynecologic oncology

et al. 2008

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Contribution of surgery in patients with bulky residual disease after chemoradiation for advanced cervical carcinoma

Cited by 66 publications

References 13 publications

Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review

Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review

Intensity-Modulated Arc Therapy with Simultaneous Integrated Boost in the Treatment of Primary Irresectable Cervical Cancer

Robot-assisted laparoscopy in gynecologic oncology

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