Contribution of Sleep Physiology to Depressive Pathophysiology

Seifritz, Erich

doi:10.1016/s0893-133x(01)00319-0

Cited by 27 publications

(12 citation statements)

References 43 publications

(29 reference statements)

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“…It is repeatedly reported that patients with depression show shortened latency to the onset of REM sleep, longer duration of REM sleep and increased eye movement frequency during REM sleep (Seifritz, 2001). Serotonin has been implicated as a molecule playing an critical role in transition between non-REM sleep and REM sleep (Jouvet, 1969).…”

Section: Role Of the Habenula In Sleepmentioning

confidence: 99%

Hyperactivation of the habenula as a link between depression and sleep disturbance

Aizawa

Cui

Tanaka

et al. 2013

Front. Hum. Neurosci.

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Depression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid eye movement (REM) sleep. Despite the coincidence of the depression and sleep disturbance, neural substrate for depressive behaviors and sleep regulation remains unknown. Habenula is an epithalamic structure regulating the activities of monoaminergic neurons in the brain stem. Since the imaging studies showed blood flow increase in the habenula of depressive patients, hyperactivation of the habenula has been implicated in the pathophysiology of the depression. Recent electrophysiological studies reported a novel role of the habenular structure in regulation of REM sleep. In this article, we propose possible cellular mechanisms which could elicit the hyperactivation of the habenular neurons and a hypothesis that dysfunction in the habenular circuit causes the behavioral and sleep disturbance in depression. Analysis of the animals with hyperactivated habenula would open the door to understand roles of the habenula in the heterogeneous symptoms such as reduced motor behavior and altered REM sleep in depression.

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Section: Role Of the Habenula In Sleepmentioning

confidence: 99%

Hyperactivation of the habenula as a link between depression and sleep disturbance

Aizawa

Cui

Tanaka

et al. 2013

Front. Hum. Neurosci.

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“…The suppression of the parasympathetic system, particularly during sleeping hours, is also closely associated with sleep disorders. 29 Failure to activate parasympathetic activity leads to an inability to initiate sleep, maintain sleep, activate REM sleep, and reach delta sleep. This constellation of events is associated with residual daytime grogginess and exacerbation of mood disorders.…”

Section: Discussionmentioning

confidence: 99%

Administration of an Amino Acid–Based Regimen for the Management of Autonomic Nervous System Dysfunction Related to Combat-Induced Illness

Shell

Charuvastra

Breitstein

et al. 2014

J Cent Nerv Syst Dis

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The etiology and pathophysiology of posttraumatic stress disorder (PTSD) remains poorly understood. The nutritional deficiencies associated with the altered metabolic processes of PTSD have not previously been studied in detail. This pilot study measured the reduction in symptoms in 21 military veterans reporting moderate to severe symptoms associated with PTSD. Two amino acid–based medical foods specifically formulated with biogenic amines and other nutrients were administered to study subjects targeting specific neurotransmitter deficiencies resulting from altered metabolic activity associated with PTSD. This study included the Physician Checklist – Military (PCL-M), Short Form General Health Survey (SF-36), and Epworth Sleepiness Scale to measure the change in each subject’s score after 30 days of administration. An average decrease of 17 points was seen in the PCL-M, indicating a reduction in PTSD symptoms (P < 0.001). The mental health component of the SF-36 showed an average 57% increase in the subjects’ mental health rating (P < 0.001). The results of this initial study demonstrate that addressing the increased dietary requirements of PTSD can improve symptoms of the disease while eliminating significant side effects. A larger, double-blind, randomized, placebo-controlled trial is warranted.

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“…Estudos fundamentais 26 colocam os valores de latência REM na depressão primária como em média de 51,3 min; na depressão secundária como sendo de 75,9 min; e em outros transtornos psíquicos com resultados de média de 76,5%. Na presente amostra não foi possível estabelecer correlação significante entre os subgrupos de severidade e achados de latência REM reduzida, correlação esta que foi verificada por Feinberg et al 27 .…”

Section: Discussionunclassified

“…O aumento da latência do sono é característico dos quadros de ansiedade portanto este dado da presente casuística concorda com a literatura 5,6,8,9,17,26,[28][29][30] .…”

Section: Discussionunclassified

Avaliação polissonográfica de pacientes ambulatoriais portadores de transtornos do humor

Souza

Maciel

Reimão

2003

Arq. Neuro-Psiquiatr.

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, Rubens Reimão 3 RESUMO -A avaliação do sono e os achados polissonográficos de 60 pacientes portadores de transtorno do humor, acompanhados em ambulatório, com média de idade de 36,1 ± 11,3 anos são apresentados ( 12 M, 48 F). Os pacientes foram submetidos a entrevista clínica, questionário do sono e a duas noites de polissonografia, sendo a segunda noite utilizada para dados estatísticos. A distimia foi o diagnóstico mais comum em 25 casos. (41,6%). Para o delineamento do estudo utilizou-se análise descritiva. As avaliações estatísticas empregadas foram o teste exato de Fisher e o teste de Kruskal-Wallis. Houve tendência para redução da continuidade do sono e aumento da densidade REM, em níveis estatisticamente não significantes. Ocorreu redução significante do sono profundo (estágio 4) diretamente relacionada com a maior severidade da depressão (p=0,0253).PALAVRAS-CHAVE: sono, distúrbios do sono, polissonografia, transtornos do humor, insônia. P P P P Polysomnographic evaluation of clinical patients suffering from mood disturbance olysomnographic evaluation of clinical patients suffering from mood disturbance olysomnographic evaluation of clinical patients suffering from mood disturbance olysomnographic evaluation of clinical patients suffering from mood disturbance olysomnographic evaluation of clinical patients suffering from mood disturbance ABSTRACT -The sleep patterns of sixty patients suffering from mood disturbance, were studied, with mean age of 36.1 ± 11.3 years ( 12 males, 48 females). These patients were submitted to two nights of nocturnal polysomnographic evaluation; the second night acquired data was employed in the statistics. The following parameters were analyzed: parameters of sleep continuity, parameters of sleep architecture, REM and non-REM sleep parameters. The patients were analyzed in accordance to depression severity, presence of sleep disorders and relevant mood disturbances. The most common diagnosis was dysthymia in 25 cases (41.6%). Descriptive analysis was used to delineate the study. The statistics evaluation used the Fisher exact test and the Kruskal-Wallis statistics heterogeneity test. There was reduction in sleep continuity and increase in REM density, both not statistic significant. Stage 4 sleep showed significant reduction in severely depressed patients (p=0.0253).KEY WORDS: sleep, sleep disorders, polysomnography, mood disorders, insomnia. Os distúrbios do sono são manifestações clínicas da depressão e cerca de 50% a 95% dos pacientes portadores de transtornos do humor apresentam queixas de sono fragmentado e superficial 1,2 . A insô-nia do tipo terminal é o relato mais frequente e a hipersônia o menos comum 1,2 . Os estudos de polissonografia em depressão focalizam principalmente a avaliação dos parâmetros da continuidade do sono, do sono REM e do sono não-REM (NREM) 3 . Nas duas últimas décadas diversos autores verificaram inicialmente a característica polissonográfica da latência REM reduzida em quadros depressivos, sendo considerada por muitos como um marcador bioló...

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Contribution of Sleep Physiology to Depressive Pathophysiology

Cited by 27 publications

References 43 publications

Hyperactivation of the habenula as a link between depression and sleep disturbance

Hyperactivation of the habenula as a link between depression and sleep disturbance

Administration of an Amino Acid–Based Regimen for the Management of Autonomic Nervous System Dysfunction Related to Combat-Induced Illness

Avaliação polissonográfica de pacientes ambulatoriais portadores de transtornos do humor

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