Contribution of single motoneurons to renshaw cell activity

Ross, H.-G.; Cleveland, Sinclair; Haase, J.

doi:10.1016/0304-3940(75)90053-1

Cited by 36 publications

(13 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interactions between individual neurones in the recurrent Renshaw circuit To date, this study and three preceding ones (Ross et al 1975(Ross et al , 1976Van Keulen, 1981) Previous studies of the relationship between the profile of an e.p.s.p. and the resulting peaks of the cross-correlogram (indicating the increase in probability of discharge) have provided evidence that the cross-correlogram peaks may have a form similar to that of the potential itself (Moore, Segundo, Perkel & Levitan, 1970), the derivative of the potential (Knox, 1974;Knox & Poppele, 1977;Fetz & Gustafsson, 1983), or a combination of both (Kirkwood & Sears, 1978Gustafsson & McCrea, 1984).…”

Section: Discussionmentioning

confidence: 89%

“…Eccles et al (1954) attributed the long duration of recurrent i.p.s.p.s evoked by antidromic volleys to the high-frequency repetitive discharge of Renshaw cells. While some Renshaw cells display prolonged bursts in response to activation of collaterals of single motor axons (Ross et al 1975(Ross et al , 1976Van Keulen, 1981) such bursts would not be expected in the majority of Renshaw cells. None the less, as shown in Table 1, the half-widths of single-axon recurrent i.p.s.p.s were similar in duration to those of recurrent i.p.s.p.s produced by composite activation.…”

Section: Values In Parentheses)mentioning

confidence: 92%

“…There is a need to supplement the results obtained by use of this approach with information on the unitary organization of synaptic connections within the recurrent Renshaw circuit. Such work is exemplified in the studies of Ross, Cleveland & Haase (1975 and Van Keulen (1981), which revealed a wide range in the responsiveness of single Renshaw cells to the recurrent input from single motor axons. Furthermore, by use of spike-triggered averaging, Van Keulen (1981) provided examples of the wide range of motoneuronal i.p.s.p.s which occur in response to the individual impulses of single Renshaw cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The measurement of single motor‐axon recurrent inhibitory post‐synaptic potentials in the cat.

Hamm

Shinji

Stuart

et al. 1987

The Journal of Physiology

115

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Values In Parentheses)mentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The measurement of single motor‐axon recurrent inhibitory post‐synaptic potentials in the cat.

Hamm

Shinji

Stuart

et al. 1987

The Journal of Physiology

115

View full text Add to dashboard Cite

show abstract

“…This would result in slowing and/or derecruitment of lowthreshold motor units, higher levels of central drive, and subsequent recruitment of new, higher-threshold units to maintain force at prepain levels. In addition, Renshaw cell-mediated recurrent inhibition could slow or inhibit discharge of smaller lowthreshold motor units upon recruitment of larger units (Ross et al, 1975;Friedman et al, 1981;De Luca, 1985). Thus, inhibition due to pain and increased central drive and/or Renshawmediated inhibition of smaller low-threshold units could change both recruitment order and population of motor units recruited during force-matched painful contractions.…”

Section: Discussionmentioning

confidence: 99%

Motor Unit Recruitment Strategies Are Altered during Deep-Tissue Pain

Butler²,

et al. 2009

View full text Add to dashboard Cite

Muscle pain is associated with decreased motor unit discharge rate during constant force contractions. As discharge rate is a determinant of force, other adaptations in strategy must explain force maintenance during pain. Our aim was to determine whether motor unit recruitment strategies are altered during pain to maintain force despite reduced discharge rate. Motor unit discharge behavior was recorded in two muscles, one with (quadriceps) and one without [flexor pollicis longus (FPL)] synergists. Motor units were recruited during matched low-force contractions with and without experimentally induced pain, and at higher force without pain. A total of 52 and 34 units were recorded in quadriceps and FPL, respectively, during low-force contractions with and without pain. Of these, 20 quadriceps and 9 FPL units were identified during both trials. The discharge rate of these units reduced during pain in both muscles [quadriceps: 8.7 (1.5) to 7.5 (1.3) Hz, p Ͻ 0.001; FPL: 11.9 (1.5) to 10.0 (1.7) Hz, p Ͻ 0.001]. All remaining units discharged only with or without pain, but not in both conditions. Only one-third of the additional units recruited during pain (quadriceps n ϭ 7/19, FPL n ϭ 3/15) were those expected given orderly recruitment of the motor unit pool as determined during higher-force contractions. We conclude that reduced motor unit discharge rate with pain is accompanied by changes in the population of units used to maintain force. The recruitment of new units is partly inconsistent with generalized inhibition of the motoneuron pool predicted by the "pain adaptation" theory, and provides the basis for a new mechanism of motor adaptation with pain.

show abstract

“…Under natural conditions, the input to Renshaw cells is not constant. Even the "steady-state" discharge of a single motoneurone, which may strongly excite a Renshaw cell (Ross et al 1975;van Keulen 1981; see also Harem et al 1987), is not completely regular, but fluctuates more or less around a mean rate. To understand the contribution of Renshaw cells to motoneurone firing fluctuation, a precise characterization of their dynamic behaviour is necessary.…”

Section: Introductionmentioning

confidence: 99%

Time constants of facilitation and depression in Renshaw cell responses to random stimulation of motor axons

et al. 1988

View full text Add to dashboard Cite

Summary. In 9 adult anaesthetized cats, 22 lumbosacral Renshaw cells recorded with NaCl-filled micropipettes were activated by random stimulation of ventral roots or peripheral nerves. The stimulus patterns had mean rates of 9.5-13 or 20-23 or 45 pulses per second and were pseudo-Poisson; short intervals below ca. 5 ms (except in two cases) were excluded. The Renshaw cell responses were evaluated by two kinds of peristimulus-time histograms (PSTHs). "Conventional" PSTHs were calculated by averaging the Renshaw cell discharge with respect to all the stimuli in a train. These PSTHs showed an early excitatory response which was often followed by a longer-lasting slight reduction of the discharge probability. These two response components were positively correlated. "Conditional" PSTHs were determined by averaging the Renshaw cell discharge with respect to the second ("test") stimulus in pairs of stimuli which were separated by varied intervals, 6. The direct effect of the first "conditional" response was subtracted from the excitation following the second ("test") stimulus so as to isolate the effect caused by the second stimulus per se. After such a correction, the effect of the first "conditioning" stimulus showed pure depression, pure facilitation or mixed facilitation/depression. Analysis of such conditioning curves yielded two time constants of facilitation (ranges: ca. 435 ms and 93-102 ms) and two of depression (ranges: ca. 7-25 ms and 50-161 ms). It is concluded that these time constants are compatible with processes of short-term synaptic plasticity known from other synapses. Other processes such as afterhyperpolarization and mutual inhibition probably are of less importance.

show abstract

Contribution of single motoneurons to renshaw cell activity

Cited by 36 publications

References 4 publications

The measurement of single motor‐axon recurrent inhibitory post‐synaptic potentials in the cat.

The measurement of single motor‐axon recurrent inhibitory post‐synaptic potentials in the cat.

Motor Unit Recruitment Strategies Are Altered during Deep-Tissue Pain

Time constants of facilitation and depression in Renshaw cell responses to random stimulation of motor axons

Contact Info

Product

Resources

About