Contribution of Plasma‐Derived Molecules to Mucosal Immune Defence, Disease and Repair in the Airways

Persson, C. G. A.; Erjefält, Jonas; Greiff, Lennart; Erjefält, I.; Korsgren, Magnus; Linden, Margareta; Sundler, F.; Andersson, Morgan; Svensson, C.

doi:10.1046/j.1365-3083.1998.00317.x

Cited by 82 publications

(80 citation statements)

References 74 publications

(168 reference statements)

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“…2 and 3). In order to insure that activation of either sPLA 2 or cPLA 2 was not responsible for increases in PAF produciton cells were pretreated with PX-18 or AACOCF 3 . Pretreatment with PX-18 had no effect on basal levels of PAF production (884 ± 107 dpm) or PAF production in response to thrombin (2177 ± 512 dpm) or tryptase (4013 ± 476 dpm) stimulation.…”

Section: Resultsmentioning

confidence: 99%

Protease activation of calcium-independent phospholipase A2 leads to neutrophil recruitment to coronary artery endothelial cells

White¹,

McHowat²

2007

Thrombosis Research

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Introduction-Thrombin or tryptase cleavage of protease-activated receptors (PAR) on human coronary artery endothelial cells (HCAEC) results in activation of a membrane-associated, calciumindependent phospholipase A 2 (iPLA 2 ) that selectively hydrolyzes plasmalogen phospholipids. Atherosclerotic plaque rupture results in a coronary ischemic event in which HCAEC in the ischemic area would be exposed to increased thrombin concentrations in addition to tryptase released by activated mast cells present in the plaque.

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Section: Resultsmentioning

confidence: 99%

Protease activation of calcium-independent phospholipase A2 leads to neutrophil recruitment to coronary artery endothelial cells

White¹,

McHowat²

2007

Thrombosis Research

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“…36 Even the tight junctions of intact epithelial cells are not obstacles for passive transfer of plasma exudate. Therefore, one may argue that IgA AMA might enter the urogenital tract from plasma by passive transfer between cells comprising the epithelial lining.…”

Section: Discussionmentioning

confidence: 99%

Mucosal Immunity and Primary Biliary Cirrhosis: Presence of Antimitochondrial Antibodies in Urine

et al. 2000

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We have shown that IgA-class antimitochondrial autoantibodies (AMA) can be detected in the bile and saliva of patients with PBC, suggesting that AMA are secreted into the luminal fluid across bile ducts and salivary glands. These data prompted us to determine whether AMA of the IgA isotype may be transported across other epithelial mucosa. Therefore, we tested for the presence of AMA in the urine specimens of 83 patients with PBC and 58 non-PBC controls including healthy individuals and patients with other liver diseases. Patients enrolled in this study had no history of renal disease, and we confirmed there was less than 50 g/mL of protein in each of the urine specimens. Interestingly, we found that AMA were present in the urine of 71/83 (86%) of all patients with PBC and in 71/78 (91%) of patients with PBC that were serum AMA positive. In contrast, AMA were not detected in any of the 58 control urine specimens. Of particular interest, AMA of the IgA isotype was present in 57/83 (69%) of patients with PBC, and in 52 of these 57, we found secretory-type IgA. In a nested random subgroup of urine samples, the prevalence of the IgA2 AMA was 6/18 (33%), significantly lower than in matched serum samples, 13/16 (81%, P ‫؍‬ .007). These data show that AMA of the IgA isotype is secreted into urine from the uroepithelium of patients with PBC, and support the thesis that PBC originated from either a mucosal challenge or a loss of mucosal tolerance. (HEPATOLOGY 2000;32: 910-915.)

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“…Secretory IgM (SIgM) antibodies contribute to a lesser extent in the normal adult, but play a significant role in mucosal defence in the neonate and in IgA-deficiency states. 32 IgG plasma cells are in low numbers at mucosal sites but serum-derived and locally produced IgG antibodies are important in protection of the respiratory 33,34 and female genital tracts. 35 The IgA antibodies in mucosal secretions are usually in the secretory form, consisting of dimeric IgA molecules joined by J chain and containing the epithelial-derived protein, secretory component.…”

Section: Common Mucosal Immune Systemmentioning

confidence: 99%

Exercise effects on mucosal immunity

Gleeson¹,

Pyne²

2000

Immunol Cell Biol

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SummaryThe present review examines the effects of exercise on mucosal immunity in recreational and elite athletes and the role of mucosal immunity in respiratory illness. Habitual exercise at an intense level can cause suppression of mucosal immune parameters, while moderate exercise may have positive effects. Saliva is the most commonly used secretion for measurement of secretory antibodies in the assessment of mucosal immune status. Salivary IgA and IgM concentrations decline immediately after a bout of intense exercise, but usually recover within 24 h. Training at an intense level over many years can result in a chronic suppression of salivary immunoglobulin levels. The degree of immune suppression and the recovery rates after exercise are associated with the intensity of exercise and the duration or volume of the training. Low levels of salivary IgM and IgA, particularly the IgA1 subclass, are associated with an increased risk of respiratory illness in athletes. Monitoring mucosal immune parameters during critical periods of training provides an assessment of the upper respiratory tract illness risk status of an individual athlete. The mechanisms underlying the mucosal immune suppression are unknown.

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Contribution of Plasma‐Derived Molecules to Mucosal Immune Defence, Disease and Repair in the Airways

Cited by 82 publications

References 74 publications

Protease activation of calcium-independent phospholipase A2 leads to neutrophil recruitment to coronary artery endothelial cells

Protease activation of calcium-independent phospholipase A2 leads to neutrophil recruitment to coronary artery endothelial cells

Mucosal Immunity and Primary Biliary Cirrhosis: Presence of Antimitochondrial Antibodies in Urine

Exercise effects on mucosal immunity

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