Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure

Judd, Nancy L.; Griffith, William C.; Faustman, Elaine M.

doi:10.1016/j.yrtph.2004.06.004

Cited by 38 publications

(24 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We confirmed the effect of fish intake on the exposure of populations to dioxins and related compounds (Judd et al 2004). However, the surprising significant role of egg consumption suggests a possible relationship with the January 1999 Belgian PCB and dioxin incident in which fats destined for animal feed production were contaminated with 40–50 kg of PCB-containing mineral oil (Bernard et al 1999; van Larebeke et al 2001).…”

Section: Discussionsupporting

confidence: 77%

Serum Dioxin-like Activity Is Associated with Reproductive Parameters in Young Men from the General Flemish Population

Dhooge

Larebeke²,

Koppen³

et al. 2006

Environ Health Perspect

View full text Add to dashboard Cite

Background2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and some related environmental contaminants are aryl hydrocarbon receptor (AhR) ligands that exert reproductive and developmental toxicity in laboratory animals. In humans, fertility-related effects are less documented.ObjectiveThe aim of this study was to investigate the relationship between dioxin-like biological activity in serum and parameters of reproductive status in men from the general population 5 months after a polychlorinated biphenyl and dioxin food-contamination episode in Belgium.DesignIn the framework of the cross-sectional Flemish Environment and Health Study (FLEHS), we recruited 101 men 20–40 years of age and evaluated sperm parameters, measured sex hormones, and gathered information on a number of lifestyle factors. In addition, we determined the AhR-mediated enzymatic response elicited by individual serum samples and expressed it as TCDD equivalent concentrations (CALUX-TEQs) using an established transactivation assay.ResultsAge (p = 0.04) and the frequency of fish (p = 0.02) and egg (p = 0.001) consumption were independent positive determinants of serum dioxin-like activity. After correcting for possible confounders, we found that a 2-fold increase in CALUX-TEQ > 16 pg/L was associated with a 7.1% and 6.8% (both p = 0.04) decrease in total and free testosterone, respectively. We also observed a more pronounced drop in semen volume of 16.0% (p = 0.03), whereas sperm concentration rose by 25.2% (p = 0.07). No relationship was found with total sperm count or sperm morphology.ConclusionsThese data suggest an interaction of dioxin-like compounds with the secretory function of the seminal vesicles or prostate, possibly indirectly through an effect on testosterone secretion, at levels not affecting spermatogenesis as such.

show abstract

Section: Discussionsupporting

confidence: 77%

Serum Dioxin-like Activity Is Associated with Reproductive Parameters in Young Men from the General Flemish Population

Dhooge

Larebeke²,

Koppen³

et al. 2006

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…The primary source of PCBs for the 10% of the US population currently most exposed to PCBs are fish high on the food chain consumed from PCB-contaminated lakes, streams, and estuaries (Judd et al, 2004). This represents a significant shift from studies in the 1960s through 1980s that often attributed the highest PCB body burdens in humans to occupational exposure.…”

Section: Introductionmentioning

confidence: 99%

Catfish consumption as a contributor to elevated PCB levels in a non-Hispanic black subpopulation

Weintraub

Birnbaum

2008

Environmental Research

View full text Add to dashboard Cite

“…In spite of the controls in place, they will be present in the environment for an extremely long time and remain a concern. While there are uncertainties regarding the extent to which they pose a threat to human health specifically through consumption of aquatic organisms minimising exposure does remain a priority [13,14]. Unless great care is taken in finding alternative chemicals for use as fire retardants more problem chemicals will appear in the future.…”

Section: Industry and Human Habitationmentioning

confidence: 99%

Chemicals in the water environment. Where do the real and future threats lie?

Fawell

2012

Annali Dell'Istituto Superiore Di Sanità

View full text Add to dashboard Cite

Abstract. There are many potential sources of chemical constituents and contaminants in water that can reach drinking water. Not all substances will be present in any particular water. Some substances may be of benefit to health but others can be a threat. However, very few have been clearly shown to cause adverse health effects in humans through drinking water and evidence may be complicated by simultaneous exposure through food. Our knowledge of contaminants in water is, however, incomplete as additional contaminants emerge with advancing analytical methods. Most of these emerging contaminants are present as a consequence of day to day use by the wider human population and control requires a different approach to the substance by substance regulation prevalent at present.Key words: drinking water, chemicals, pollution, health.Riassunto (Sostanze chimiche nell'ambiente acquatico. Quali sono le minacce attuali e future?). Sono molte le fonti potenziali di costituenti e contaminanti chimici nell'acqua che possono raggiungere le acque potabili. Non tutte le sostanze sono presenti in ogni acqua, alcune possono giovare alla salute ma altre possono rappresentare una minaccia. Tuttavia, solo per un numero limitato di sostanze è stata chiaramente dimostrata una relazione causale per effetti avversi sulla salute associata al consumo di acqua potabile e le evidenze sono rese complicate dalla simultanea esposizione attraverso gli alimenti. La conoscenza dei contaminanti nelle acque è comunque incompleta poiché nuovi contaminanti emergono con lo sviluppo di metodi analitici avanzati. Gran parte di questi contaminanti è presente come conseguenza dell'uso quotidiano da parte di una popolazione crescente e i controlli richiedono un approccio regolatorio diverso da quello attuale basato sulle singole sostanze.Parole chiave: acque potabili, sostanze chimiche, contaminazione, salute.

show abstract

Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure

Cited by 38 publications

References 47 publications

Serum Dioxin-like Activity Is Associated with Reproductive Parameters in Young Men from the General Flemish Population

Serum Dioxin-like Activity Is Associated with Reproductive Parameters in Young Men from the General Flemish Population

Catfish consumption as a contributor to elevated PCB levels in a non-Hispanic black subpopulation

Chemicals in the water environment. Where do the real and future threats lie?

Contact Info

Product

Resources

About