Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment

Simplicio, Janaina A.; Resstel, Leonardo Barbosa Moraes; Tirapelli, Daniela P.C.; D’Orléans-Juste, Pedro; Tirapelli, Carlos Renato

doi:10.1016/j.vph.2015.06.015

Cited by 27 publications

(15 citation statements)

References 45 publications

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“…To measure SOD activity, we utilized SOD Assay Kit (#19160; Sigma‐Aldrich, St. Louis, MO, USA), according to the method used by Simplicio et al . The results were normalized for protein concentration, and SOD activity is expressed as % inhibition rate/mg protein.…”

Section: Methodsmentioning

confidence: 99%

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Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection

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Santello

Colato

et al. 2017

Journal of Pineal Research

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The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase-SOD and reduced glutathione levels (GSH) to understand whether age-related changes would influence the development of acute Trypanosoma cruzi (T. cruzi) infection. Young- (5 weeks) and middle-aged (18 months) Wistar rats were orally treated with melatonin (gavage) (05 mg/kg/day), 9 days after infection. A significant increase in both SOD activity and GSH levels was found in plasma from all middle-aged melatonin-treated animals. Melatonin triggered enhanced expression of major histocompatibility class II (MHC-II) antigens on antigen-presenting cell (APC) and peritoneal macrophages in all treated animals. High levels of CD4 CD28-negative T cells (*P<.05) were detected in middle-aged control animals. Melatonin induced a significant reduction (***P<.001) in CD28-negative in CD4 and CD8 T cells in middle-aged control animals. Contrarily, the same group displayed upregulated CD4 CD28 T and CD8 CD28 T cells. Melatonin also triggered an upregulation of CD80 and CD86 expression in all young-treated groups. Significant percentages of B and spleen dendritic cells in middle-aged infected and treated animals were observed. Our data reveal new features of melatonin action in inhibiting membrane lipid peroxidation, through the reduction in 8-isoprostane, upregulating the antioxidant defenses and triggering an effective balance in the antioxidant/oxidant status during acute infection. The ability of melatonin to counteract the immune alterations induced by aging added further support to its use as a potential therapeutic target not only for T. cruzi infection but also for other immunocompromised states.

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Section: Methodsmentioning

confidence: 99%

“…For GSH determination, the supernatants were analyzed for GSH content through its interaction with 5,5′‐dithio‐bis‐(2‐nitrobenzoic acid) (DTNB) as previously described by Simplicio et al . The results are expressed as μg/mg protein.…”

Section: Methodsmentioning

confidence: 99%

Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection

Brazão

Santello

Colato

et al. 2017

Journal of Pineal Research

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“…An array of research papers has been published on the subject of the potential antioxidant/pro-oxidant activity of SSRIs. The majority of these studies have been performed in vivo, using rodents (Eren et al 2007;Zafir and Banu 2007;Garg and Kumar 2008;Dursun et al 2009;Kumar and Kumar 2009;Zafir et al 2009;Kirkova et al 2010;Lobato et al 2010;Chung et al 2010a, b;Djordjevic et al 2011;Inkielewicz-Stêpniak 2011;Kumar et al 2011;Lee et al 2011;Abdel-Sater et al 2012;Moretti et al 2012;Abdel-Salam et al 2013;Kassan et al 2013;Qiu et al 2013;Erdemir et al 2014;Aksu et al 2014;Battal et al 2014;Shahzad et al 2014;Zlatković et al 2014;da Silva et al 2014da Silva et al , 2015Sakr et al 2015;Simplicio et al 2015;Galal et al 2016;Herbet et al 2016;Braz et al 2016b;Karimi-Khouzani et al 2017;Rebai et al 2017;Schoeman et al 2017;Wang et al 2017;Shafiey et al 2018;Simões-Alves et al 2018) or, rarely, invertebrates, (Mytilus galloprovincialis) (Gonzalez-Rey and Bebianno 2013;Franzell...…”

Section: Redox Homeostasis Modulation By Ssrismentioning

confidence: 99%

Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects

et al. 2020

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Depressive disorders are amongst the greatest mental health challenges, with an increasing number of patients being diagnosed each year. Though it has not yet been fully elucidated, redox metabolism imbalances and oxidative stress seem to play a major role in the pathogenesis of depressive disorders. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressants, considered to have a better tolerability. However, several adverse effects have been reported and the mechanisms involved in their pharmacological activity are not entirely understood. SSRIs have been shown to influence the redox metabolism, which could be involved in their toxicity and pharmacological effects. A comparative analysis of published in vivo and in vitro data regarding the activity of SSRIs on the redox metabolism pathways has been performed in this paper, with an emphasis on mechanistical aspects. Furthermore, a comparison between oxidative stress biomarker levels reported by different studies was attempted. The reviewed data point towards both pro-and antioxidant effects of SSRIs, dependent on tissue/cell type and dose/concentration, suggest a redox modulating potential of these compounds. In hepatic and testicular tissue, the majority of reviewed studies reported pro-oxidant effects, with possible implications towards the hepatotoxicity and sexual dysfunction that were reported following SSRI treatment; while in brain, the most common findings were antioxidant effects that could partially explain their antidepressant activity. However, given the heterogeneity of the reviewed data, further research is needed to fully understand the impact of SSRIs on redox metabolism and its implications.

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“…Increased oxidative stress is a hallmark of aging, including vascular aging. Interestingly, chronic fluoxetine treatment was shown to induce increased oxidative stress in multiple organs (Zlatkovic et al, 2014) and aging-like phenotypic changes in vascular endothelial function in preclinical models (Simplicio et al, 2015).…”

Section: Potential Progeronic Effects Of Fluoxetinementioning

confidence: 99%

Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation

et al. 2019

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Late life depression is an important public health problem, which associates with increased risk of morbidity and mortality. Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are often prescribed to treat geriatric depression. There is increasing evidence that fluoxetine and other SSRIs exert a wide range of cardiovascular side effects. Furthermore, there is evidence that aging may increase plasma level of SSRIs. In this overview, the potential role of side effects of treatment with fluoxetine and other SSRIs in the pathogenesis of age-related cardiovascular diseases, including atherogenesis, cardiac pathologies, and cerebromicrovascular impairment, is discussed.

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Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment

Cited by 27 publications

References 45 publications

Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection

Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection

Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects

Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation

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