Contribution of obesity to hepatitis C-related fibrosis progression

Ortiz, Vicente; Berenguer, Marina; Rayón, José M.; Carrasco, Domingo; Berenguer, J

doi:10.1111/j.1572-0241.2002.05995.x

Cited by 199 publications

(142 citation statements)

References 21 publications

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“…3,25,26 One study has suggested that antioxidant defense mechanism deteriorates with age, and leaves the liver vulnerable to oxidative stress. 27 Our finding was consistent with the literature.…”

Section: Discussionsupporting

confidence: 83%

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Ceylan¹,

Yardimci²,

Fincancı³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to investigate the independent variables for the degree of liver fibrosis in patients with chronic hepatitis C virus (HCV) infection. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this cross-sectional retrospective study, the patients were divided in two groups as Group A (patients with fibrosis score 0-2) and Group B (patients with fibrosis score 3-4) and they were compared in terms of age, gender, body mass index, alcohol consumption, presence of diabetes, serum HCV RNA, alanine aminotransferase, gamma-glutamyl transferase, and aspartate aminotransferase, total bilirubin, albumin, globulin and alkaline phosphatase levels, prothrombin time, blood thrombocyte count, splenomegaly in ultrasonographic examination, HCV genotype and liver steatosis. R Re es su ul lt ts s: : Of 201 patients, 93 (46.3%) were males; the median age was 51 (range: 18-77) years. It was found that serum gamma-glutamyl transferase and aspartate aminotransferase levels, age, prothrombin time and the presence of splenomegaly were independent variables predictive of advanced liver fibrosis. Odds ratio and p values were 1.984 and 0.013 for gamma-glutamyl transferase, 1.633 and 0.018 for aspartate aminotransferase, 1.861 and 0.003 for age, 5.598 and 0.008 for splenomegaly and 0.541 and 0.007 for prothrombin time, respectively. C Co on nc cl lu us si io on n: : The results of this study suggested that advanced age, elevated serum gamma-glutamyl transferase and, aspartate aminotransferase levels, prolonged prothrombin time and the presence of splenomegaly are independent variables determining severe liver fibrosis. K Ke ey y W Wo or rd ds s: : Liver cirrhosis; hepacivirus Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı kronik hepatit C virüsü (HCV) enfeksiyonlu olgularda karaciğer fibrozunun derecesini belirleyen bağımsız değişkenleri araştırmaktı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu geriye dönük kesitsel çalışmada hastalar Grup A (fibroz skoru 0-2 olanlar) ve Grup B (fibroz skoru 3-4 olanlar) olarak iki gruba ayrıldı ve gruplar yaş, cinsiyet, beden kitle indeksi, alkol kullanımı, diyabet varlığı, serum HCV RNA, alanin aminotransferaz, gama-glutamil transferaz, aspartat aminotransferaz, total bilirubin, albumin, globulin ve alkalen fosfataz seviyeleri, protrombin zamanı, kan trombosit sayısı, ultrasonografide splenomegali varlığı, HCV genotip ve karaciğer yağlanması açısın-dan karşılaştırıldı. B Bu ul lg gu ul la ar r: : İkiyüz bir hastadan 93 (%46,3)'ü erkekti ve ortanca yaş 51 (alt ve üst sınırlar: 18-77 yıl) idi. Serum gama-glutamil transferaz ve aspartat aminotransferaz düzeyleri, yaş, protrombin zamanı ve splenomegalinin ileri karaciğer fibrozunu belirleyen bağımsız değişkenler olduğu bulundu. Odds oranı ve p değerleri gamaglutamil transferaz için 1,984 ve 0,013; aspartat aminotransferaz için 1,633 ve 0,018; yaş için 1,861 ve 0,003; splenomegali için 5,598 ve 0,008 ve protrombin zamanı için 0,541 ve 0,007 idi. S So on nu uç ...

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Section: Discussionsupporting

confidence: 83%

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Ceylan¹,

Yardimci²,

Fincancı³

et al. 2012

Turkiye Klinikleri J Med Sci

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“…Several patients had previously described risk factors for liver fibrosis progression such as obesity (27,28), use of cannabis (29), smoking(30), exposure to HBV (31) and excessive intake of alcohol (32). We found associations between advanced liver fibrosis and alcohol consumption, increased BMI and the presence of anti-HBc antibodies.…”

Section: Discussionsupporting

confidence: 52%

Chronic hepatitis C in Swedish subjects receiving opiate substitution therapy—Factors associated with advanced fibrosis

Jerkeman

Westin

Lagging

et al. 2014

Scandinavian Journal of Infectious Diseases

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Chronic hepatitis C in Swedish subjects receiving opiate substitution therapy-Factors associated with advanced fibrosis.OGIONWO JERKEMAN, ANNA; Westin, Johan; Lagging, Martin; Norkrans, Gunnar; Lidman, Christer; Frimand, Jan; Simonsberg, Christian; Kakko, Johan; Widell, Anders; Björkman, Per Link to publication Citation for published version (APA): Jerkeman, A., Westin, J., Lagging, M., Norkrans, G., Lidman, C., Frimand, J., ... Björkman, P. (2014). Chronic hepatitis C in Swedish subjects receiving opiate substitution therapy-Factors associated with advanced fibrosis. Scandinavian Journal of Infectious Diseases, 46(5), 340-347. DOI: 10.3109/00365548.2013.879994 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal

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“…[2][3][4][5][6][7][8] Other parameters have been recently unearthed or remain controversial, such as steatosis, overweight, diabetes, and tobacco use. [9][10][11][12] Nevertheless, progression of fibrosis may occur in the absence of any identified profibrogenic factor, therefore warranting further research in that field.…”

mentioning

confidence: 99%

Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C

Hézode¹,

Roudot‐Thoraval²,

Nguyen³

et al. 2005

Hepatology

258

191

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Cannabinoids present in Cannabis sativa (marijuana) exert biological effects via cannabinoid receptors CB1 and CB2. We recently demonstrated that CB1 and CB2 receptors regulate progression of experimental liver fibrosis. We therefore investigated the impact of cannabis smoking on fibrosis progression rate in patients with chronic hepatitis C (CHC). Two hundred seventy consecutive untreated patients with CHC of known duration undergoing liver biopsy were studied. Demographic, epidemiological, metabolic, and virological data were recorded, and detailed histories of cannabis, alcohol, and tobacco use over the span of hepatitis C virus infection were obtained.

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Contribution of obesity to hepatitis C-related fibrosis progression

Cited by 199 publications

References 21 publications

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Chronic hepatitis C in Swedish subjects receiving opiate substitution therapy—Factors associated with advanced fibrosis

Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C

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