Contribution of NDM and OXA-type carbapenemases to carbapenem resistance in clinical Acinetobacter baumannii from Nigeria

Genetic support of carbapenemases: a One Health systematic review and meta‐analysis of current trends in Africa

“…Two Egyptian studies, by Al‐Hassan et al . and Lopes et al ., 62 , 63 and a Nigerian study, Ogbolu et al ., 57 reported a remarkable variety of the bla OXA‐51‐like genes. Al‐Hassan et al .…”

“…In addition, bla OXA‐23‐like , bla OXA‐24‐like , bla OXA‐51‐like , bla OXA‐58‐like , and bla OXA235 were detected mostly in clinical Acinetobacter spp. In particular, bla OXA‐23‐like was detected in Egypt 56,96,110 and South Africa, 61,111 and specifically reported in clinical A. baumannii in Algeria, 59,112,113 Egypt, 62,63,99,114 Kenya, 58,115 Nigeria, 57 Senegal, 116 South Africa, 117,118 Tunisia, 119,120 and Uganda; 121 bla OXA‐23 was detected in clinical P. aeruginosa in Tunisia; 122 bla OXA‐24‐like ARGs were detected in clinical A. baumannii in Algeria, 59 Egypt, 99 South Africa, 111 and Uganda; 121 bla OXA‐40 was detected in Egypt; 62 bla OXA‐72 was detected in Algeria; 112 and bla OXA‐51‐like ARGs were detected mostly in clinical A. baumannii in Egypt, 56,96,110,123 Kenya, 58 and South Africa 61,111 . Other bla OXA‐51‐like variants were specifically identified in clinical A. baumannii in Algeria, 59,112 Egypt, 99,114 Senegal, 116 South Africa, 118 and Uganda; 121 bla OXA‐66 in clinical isolates in Kenya 58 and Tunisia; 120 and bla OXA‐94 in clinical isolates in Tunisia 60 .…”

“…Clinical A. baumannii STs were found in Egypt 56 and were shared among other countries, including Nigeria 57 (ST1 and ST10), Kenya 58 (ST2), and Algeria 59 and Tunisia 60 (ST85). In addition, A. baumannii ST25 was identified in Algeria 59 and Kenya, 58 ST113 in Kenya 58 and Nigeria, 57 and ST208 in South Africa 61 and Egypt; 62,63 K. pneumoniae ST11 was identified in Libya, 64 Morocco, 65 and Tunisia, 66 while ST14 was found in Tunisia 66 and two South African studies; 67,68 K. pneumoniae ST17 was found in Egypt 69 and South Africa, 18 while ST196 was detected in Morocco 65 and Tunisia; 66 K. pneumoniae ST307 was identified in Morocco, 70 South Africa, 18 and Tunisia, 71 while ST392 occurred in Morocco 65 and Tunisia; 72 and E. coli ST410 was found in clinical isolates in Egypt, 73 Ghana, 74 and São Tomé and Príncipe 75 . Interestingly, both E. coli and K. pneumoniae showed relatively high dissemination of certain STs among the same and different countries at different timeframes, suggesting their persistence within those countries.…”

“…detected bla OXA‐51 , bla OXA‐67 , bla OXA‐68 , bla OXA‐69 , bla OXA‐91 , bla OXA‐130 , bla OXA‐64 , bla OXA‐180 , and bla OXA‐203 . Bla OXA‐58‐like was detected in clinical A. baumannii in South Africa, 61,111 while bla OXA‐58 was specifically detected in Algeria, 59 Egypt, 62,99 and Nigeria; 57 bla OXA‐97 was detected in Tunisia; 124 and bla OXA235 was detected in Nigeria 57 …”

“…Additionally, Ramsamy et al . found bla NDM‐1 on multireplicon plasmids in South Africa; 127 in Nigeria, Ogbolu and coworkers found different Col plasmids (Col, Col‐pvc, and ColMG828) in A. baumannii isolates harboring bla NDM ; 57 and bla NDM was further identified on IncP 128 and IncF 71 plasmids, as well as on the other Inc groups, in Tunisia. Despite the variation of the replicons among the investigated countries, only IncL/M had a statistically significant association with countries ( P = 0.021313) (Fig.…”